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Gene: Entpd1 (ectonucleoside triphosphate diphosphohydrolase 1) Rattus norvegicus
Symbol: Entpd1
Name: ectonucleoside triphosphate diphosphohydrolase 1
Description: Exhibits ATPase activity; adenosine-diphosphatase activity; and identical protein binding activity. Involved in several processes, including cellular response to cytokine stimulus; response to amino acid; and response to purine-containing compound. Localizes to several cellular components, including the basolateral plasma membrane; extracellular space; and synaptic vesicle. Biomarker of demyelinating disease; hypothyroidism; intrahepatic cholestasis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 64. Orthologous to human ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1); PARTICIPATES IN purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH (RS)-amphetamine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATPDase; ecto-apyrase; ecto-ATP diphosphohydrolase 1; ecto-ATPase 1; ecto-ATPDase 1; lymphoid cell activation antigen; NTPDase 1; NTPDase-1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01259,692,020 - 259,818,922 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01267,401,518 - 267,432,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01267,183,177 - 267,259,665 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,783,750 - 245,887,419 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11245,894,247 - 246,001,894 (+)NCBI
Celera1235,318,582 - 235,397,159 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Entpd1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69265
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.