Enables ATP hydrolysis activity; adenosine-diphosphatase activity; and identical protein binding activity. Involved in several processes, including cellular response to cytokine stimulus; response to amino acid; and response to purine-containing compound. Located in several cellular components, including basolateral plasma membrane; postsynaptic density; and synaptic vesicle. Biomarker of demyelinating disease; hypothyroidism; intrahepatic cholestasis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 64. Orthologous to human ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1); PARTICIPATES IN purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ENTPD1 mRNA, [Tetrachlorodibenzodioxin co-treated with TGFB1 protein] results in increased expression of ENTPD1 mRNA
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein] more ...
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENTPD1 mRNA
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENTPD1 mRNA
[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ENTPD1 gene, [Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ENTPD1 mRNA
SIGMAR1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA], XBP1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA]
ENTPD1 protein inhibits the reaction [Silicon Dioxide analog promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENTPD1 mRNA
ENTPD1 protein inhibits the reaction [Silicon Dioxide analog promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ENTPD1 gene, [Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ENTPD1 mRNA