Enables ADP phosphatase activity; ATP hydrolysis activity; and identical protein binding activity. Involved in several processes, including cellular response to aluminum ion; cellular response to cytokine stimulus; and negative regulation of dopamine secretion. Located in several cellular components, including basolateral plasma membrane; synaptic membrane; and synaptic vesicle. Biomarker of demyelinating disease; hypothyroidism; intrahepatic cholestasis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 64. Orthologous to human ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1); PARTICIPATES IN purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ENTPD1 mRNA and [Tetrachlorodibenzodioxin co-treated with TGFB1 protein] results in increased expression of ENTPD1 mRNA
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein] more ...
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENTPD1 mRNA
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENTPD1 mRNA
[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ENTPD1 gene and [Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ENTPD1 mRNA
SIGMAR1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA] and XBP1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA]
ENTPD1 protein inhibits the reaction [Silicon Dioxide analog promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENTPD1 mRNA
ENTPD1 protein inhibits the reaction [Silicon Dioxide analog promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ENTPD1 gene and [Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ENTPD1 mRNA
Expression of ecto-nucleoside triphosphate diphosphohydrolase1-3 (NTPDase1-3) by cortical astrocytes after exposure to pro-inflammatory factors in vitro.
The expression level of ecto-NTP diphosphohydrolase1/CD39 modulates exocytotic and ischemic release of neurotransmitters in a cellular model of sympathetic neurons.
Activities of enzymes that hydrolyze adenine nucleotides in platelets from rats experimentally demyelinated with ethidium bromide and treated with interferon-beta.
Histochemical detection of ischemia-like alterations induced in kidney tissue in vitro--different sensitivity to oxidant stress of glomerular ENTPD1 versus E5NT.
