Entpd1 (ectonucleoside triphosphate diphosphohydrolase 1) - Rat Genome Database

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Gene: Entpd1 (ectonucleoside triphosphate diphosphohydrolase 1) Rattus norvegicus
Symbol: Entpd1
Name: ectonucleoside triphosphate diphosphohydrolase 1
RGD ID: 69265
Description: Enables ADP phosphatase activity; ATP hydrolysis activity; and identical protein binding activity. Involved in several processes, including cellular response to cytokine stimulus; response to amino acid; and response to purine-containing compound. Located in several cellular components, including basolateral plasma membrane; synaptic membrane; and synaptic vesicle. Biomarker of demyelinating disease; hypothyroidism; intrahepatic cholestasis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 64. Orthologous to human ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1); PARTICIPATES IN purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATPDase; ecto-apyrase; ecto-ATP diphosphohydrolase 1; ecto-ATPase 1; ecto-ATPDase 1; LOC103689954; lymphoid cell activation antigen; NTPDase 1; NTPDase-1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21239,425,515 - 239,552,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1239,425,430 - 239,552,317 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1247,609,333 - 247,694,716 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01254,313,067 - 254,391,812 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01246,966,100 - 247,044,845 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01259,692,020 - 259,818,922 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1259,739,955 - 259,819,494 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01267,183,177 - 267,259,665 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01267,401,518 - 267,432,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,783,750 - 245,887,419 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11245,894,247 - 246,001,894 (+)NCBI
Celera1235,318,582 - 235,397,159 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
cerivastatin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cyhalothrin  (EXP)
cytarabine  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
flavonoids  (EXP)
formaldehyde  (ISO)
gentamycin  (EXP)
glucose  (ISO)
isoprenaline  (ISO)
lead(0)  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
pirinixic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP,ISO)
toluene  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Plasma hemopexin activity in pregnancy and preeclampsia. Bakker WW, etal., Hypertens Pregnancy. 2007;26(2):227-39.
2. In vitro effects of L-arginine and guanidino compounds on NTPDase1 and 5'-nucleotidase activities from rat brain synaptosomes. Balz D, etal., Int J Dev Neurosci. 2003 Apr;21(2):75-82.
3. Increased NTPDase activity in lymphocytes during experimental sepsis. Bertoncheli Cde M, etal., ScientificWorldJournal. 2012;2012:941906. doi: 10.1100/2012/941906. Epub 2012 May 3.
4. Kinetic characterization and immunodetection of ecto-ATP diphosphohydrolase (EC in cultured hippocampal neurons. Boeck CR, etal., Neurochem Int. 2002 Apr;40(5):449-53.
5. Upregulation of the enzyme chain hydrolyzing extracellular ATP after transient forebrain ischemia in the rat. Braun N, etal., J Neurosci. 1998 Jul 1;18(13):4891-900.
6. Expression of ecto-nucleoside triphosphate diphosphohydrolase1-3 (NTPDase1-3) by cortical astrocytes after exposure to pro-inflammatory factors in vitro. Brisevac D, etal., J Mol Neurosci. 2013 Nov;51(3):871-9. doi: 10.1007/s12031-013-0088-3. Epub 2013 Aug 29.
7. Hypo-and hyperthyroidism affect the ATP, ADP and AMP hydrolysis in rat hippocampal and cortical slices. Bruno AN, etal., Neurosci Res. 2005 May;52(1):61-8.
8. The expression level of ecto-NTP diphosphohydrolase1/CD39 modulates exocytotic and ischemic release of neurotransmitters in a cellular model of sympathetic neurons. Corti F, etal., J Pharmacol Exp Ther. 2011 May;337(2):524-32. doi: 10.1124/jpet.111.179994. Epub 2011 Feb 16.
9. Acute caffeine treatment increases extracellular nucleotide hydrolysis from rat striatal and hippocampal synaptosomes. da Silva RS, etal., Neurochem Res. 2003 Aug;28(8):1249-54.
10. Proline induces alterations on nucleotide hydrolysis in synaptosomes from cerebral cortex of rats. Delwing D, etal., Brain Res. 2007 May 29;1149:210-5. Epub 2007 Feb 28.
11. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Enjyoji K, etal., Nat Med 1999 Sep;5(9):1010-7.
12. Extracellular ATP induces albuminuria in pregnant rats. Faas MM, etal., Nephrol Dial Transplant. 2010 Aug;25(8):2468-78. doi: 10.1093/ndt/gfq095. Epub 2010 Mar 11.
13. Determination of native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes. Failer BU, etal., Eur J Biochem. 2003 Apr;270(8):1802-9.
14. Removal from the membrane affects the interaction of rat osseous plate ecto-nucleosidetriphosphate diphosphohydrolase-1 with substrates and ions. Garcon DP, etal., J Membr Biol. 2008 Jul-Aug;224(1-3):33-44. doi: 10.1007/s00232-008-9128-2. Epub 2008 Oct 8.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Dynamic motions of CD39 transmembrane domains regulate and are regulated by the enzymatic active site. Grinthal A and Guidotti G, Biochemistry 2004 Nov 2;43(43):13849-58.
18. Modulation of nucleoside triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection. Imai M, etal., Mol Med. 1999 Nov;5(11):743-52.
19. In vitro and in vivo interactions of aluminum on NTPDase and AChE activities in lymphocytes of rats. Kaizer RR, etal., Cell Immunol. 2010;265(2):133-8. doi: 10.1016/j.cellimm.2010.08.001. Epub 2010 Aug 13.
20. An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain. Kegel B, etal., Neuropharmacology 1997 Sep;36(9):1189-200.
21. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
22. Overexpression of CD39/nucleoside triphosphate diphosphohydrolase-1 decreases smooth muscle cell proliferation and prevents neointima formation after angioplasty. Koziak K, etal., J Thromb Haemost. 2008 Jul;6(7):1191-7. doi: 10.1111/j.1538-7836.2008.03019.x. Epub 2008 Jul 1.
23. Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis. Lavrnja I, etal., Neurochem Int. 2009 Sep;55(4):193-8. doi: 10.1016/j.neuint.2009.02.013. Epub 2009 Mar 5.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Enhanced NTPDase and 5'-nucleotidase activities in diabetes mellitus and iron-overload model. Miron VR, etal., Mol Cell Biochem. 2007 Apr;298(1-2):101-7. Epub 2006 Nov 21.
26. Up-regulation of ectonucleotidase activity after cortical stab injury in rats. Nedeljkovic N, etal., Cell Biol Int. 2006 Jun;30(6):541-6. Epub 2006 Mar 22.
27. Developmental profile of NTPDase activity in synaptic plasma membranes isolated from rat cerebral cortex. Nedeljkovic N, etal., Int J Dev Neurosci. 2005 Feb;23(1):45-51.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Neonatal morphine exposure alters E-NTPDase activity and gene expression pattern in spinal cord and cerebral cortex of rats. Rozisky JR, etal., Eur J Pharmacol. 2010 Sep 10;642(1-3):72-6. doi: 10.1016/j.ejphar.2010.05.044. Epub 2010 Jun 8.
34. Activities of enzymes that hydrolyze adenine nucleotides in platelets from rats experimentally demyelinated with ethidium bromide and treated with interferon-beta. Spanevello RM, etal., Life Sci. 2007 Feb 27;80(12):1109-14. Epub 2006 Dec 8.
35. Histochemical detection of ischemia-like alterations induced in kidney tissue in vitro--different sensitivity to oxidant stress of glomerular ENTPD1 versus E5NT. Vlaar AP, etal., Nephron Physiol. 2009;111(1):p1-8. doi: 10.1159/000183178. Epub 2008 Dec 16.
36. Noise exposure induces up-regulation of ecto-nucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea. Vlajkovic SM, etal., Neuroscience. 2004;126(3):763-73.
37. Widespread expression of ecto-apyrase (CD39) in the central nervous system. Wang TF and Guidotti G, Brain Res. 1998 Apr 20;790(1-2):318-22.
38. CD39 is an ecto-(Ca2+,Mg2+)-apyrase. Wang TF and Guidotti G, J Biol Chem 1996 Apr 26;271(17):9898-901.
39. Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene. Wang TF, etal., Brain Res Mol Brain Res 1997 Jul;47(1-2):295-302.
40. N-linked oligosaccharides affect the enzymatic activity of CD39: diverse interactions between seven N-linked glycosylation sites. Wu JJ, etal., Mol Biol Cell. 2005 Apr;16(4):1661-72. Epub 2005 Jan 26.
41. Purinergic receptor activation inhibits osmotic glial cell swelling in the diabetic rat retina. Wurm A, etal., Exp Eye Res. 2008 Oct;87(4):385-93. doi: 10.1016/j.exer.2008.07.004. Epub 2008 Jul 18.
42. Expression, purification and crystallization of the ecto-enzymatic domain of rat E-NTPDase1 CD39. Zhong X, etal., Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):1063-5. doi: 10.1107/S1744309108032569. Epub 2008 Oct 31.
43. Lipopolysaccharide alters ecto-ATP-diphosphohydrolase and causes relocation of its reaction product in experimental intrahepatic cholestasis. Zinchuk VS, etal., Cell Tissue Res. 2001 Apr;304(1):103-9.
Additional References at PubMed
PMID:8955160   PMID:10581401   PMID:11929769   PMID:12031690   PMID:15307889   PMID:16480902   PMID:17401661   PMID:17574764   PMID:17619139   PMID:17686601   PMID:18256932   PMID:18554575  
PMID:19463911   PMID:19946888   PMID:20359849   PMID:20458337   PMID:22100451   PMID:22216925   PMID:23677997   PMID:25278365   PMID:28217922   PMID:30507864   PMID:31085558  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21239,425,515 - 239,552,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1239,425,430 - 239,552,317 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1247,609,333 - 247,694,716 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01254,313,067 - 254,391,812 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01246,966,100 - 247,044,845 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01259,692,020 - 259,818,922 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1259,739,955 - 259,819,494 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01267,183,177 - 267,259,665 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01267,401,518 - 267,432,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,783,750 - 245,887,419 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11245,894,247 - 246,001,894 (+)NCBI
Celera1235,318,582 - 235,397,159 (+)NCBICelera
Cytogenetic Map1q54NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381095,694,186 - 95,877,266 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1095,711,779 - 95,877,266 (+)EnsemblGRCh38hg38GRCh38
GRCh371097,471,521 - 97,637,023 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361097,461,526 - 97,627,013 (+)NCBINCBI36Build 36hg18NCBI36
Build 341097,505,905 - 97,616,454NCBI
Celera1091,256,620 - 91,378,232 (+)NCBICelera
Cytogenetic Map10q24.1NCBI
HuRef1091,099,222 - 91,264,599 (+)NCBIHuRef
CHM1_11097,753,378 - 97,918,865 (+)NCBICHM1_1
T2T-CHM13v2.01096,573,293 - 96,756,364 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391940,600,810 - 40,730,046 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1940,600,810 - 40,730,046 (+)EnsemblGRCm39 Ensembl
GRCm381940,612,366 - 40,741,602 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1940,612,366 - 40,741,602 (+)EnsemblGRCm38mm10GRCm38
MGSCv371940,734,284 - 40,816,092 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361940,751,297 - 40,794,913 (+)NCBIMGSCv36mm8
Celera1941,460,982 - 41,543,158 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1934.25NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555072,036,050 - 2,137,377 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555072,035,918 - 2,141,327 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan110107,602,465 - 107,811,326 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01092,365,267 - 92,511,852 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11095,871,671 - 95,983,257 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1095,828,094 - 95,983,257 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1289,181,851 - 9,311,835 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl289,211,050 - 9,323,939 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha289,357,708 - 9,489,400 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0289,444,087 - 9,575,820 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl289,475,293 - 9,595,910 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1289,160,534 - 9,292,221 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0289,220,048 - 9,351,993 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0289,363,303 - 9,495,027 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl14107,263,449 - 107,389,010 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114107,263,546 - 107,390,923 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214116,897,330 - 117,022,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1988,921,826 - 89,034,418 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl988,922,007 - 89,032,880 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604849,731,265 - 49,906,385 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247377,084,818 - 7,191,918 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247377,011,792 - 7,193,903 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Entpd1
576 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:48
Interacting mature miRNAs:51
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21239,552,003 - 239,552,220 (+)MAPPERmRatBN7.2
Rnor_6.01259,988,751 - 259,988,967NCBIRnor6.0
Rnor_6.01259,818,609 - 259,818,825NCBIRnor6.0
Rnor_5.01267,261,806 - 267,262,022UniSTSRnor5.0
Rnor_5.01267,431,948 - 267,432,164UniSTSRnor5.0
RGSC_v3.41245,889,560 - 245,889,776UniSTSRGSC3.4
Celera1235,396,846 - 235,397,062UniSTS
Cytogenetic Map1q54UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21239,544,484 - 239,544,689 (+)MAPPERmRatBN7.2
Rnor_6.01259,811,015 - 259,811,219NCBIRnor6.0
Rnor_6.01259,981,232 - 259,981,436NCBIRnor6.0
Rnor_5.01267,424,429 - 267,424,633UniSTSRnor5.0
Rnor_5.01267,254,212 - 267,254,416UniSTSRnor5.0
Celera1235,389,567 - 235,389,771UniSTS
Cytogenetic Map1q54UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21239,549,937 - 239,550,222 (+)MAPPERmRatBN7.2
Rnor_6.01259,986,685 - 259,986,969NCBIRnor6.0
Rnor_6.01259,816,543 - 259,816,827NCBIRnor6.0
Rnor_5.01267,259,740 - 267,260,024UniSTSRnor5.0
Rnor_5.01267,429,882 - 267,430,166UniSTSRnor5.0
RGSC_v3.41245,887,494 - 245,887,778UniSTSRGSC3.4
Celera1235,394,780 - 235,395,064UniSTS
Cytogenetic Map1q54UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 19 2 13 8 19 27 11
Low 2 24 55 41 6 41 8 11 66 16 14 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000019751   ⟹   ENSRNOP00000019751
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1239,521,237 - 239,552,317 (+)Ensembl
Rnor_6.0 Ensembl1259,958,310 - 259,981,938 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000054719   ⟹   ENSRNOP00000051602
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1239,473,442 - 239,552,317 (+)Ensembl
Rnor_6.0 Ensembl1259,739,955 - 259,819,494 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115487   ⟹   ENSRNOP00000082116
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1239,516,512 - 239,552,317 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115846   ⟹   ENSRNOP00000096959
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1239,425,430 - 239,552,317 (+)Ensembl
RefSeq Acc Id: NM_022587   ⟹   NP_072109
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21239,473,442 - 239,552,317 (+)NCBI
Rnor_6.01259,739,979 - 259,818,922 (+)NCBI
Rnor_5.01267,183,177 - 267,259,665 (+)NCBI
RGSC_v3.41245,783,750 - 245,887,419 (+)RGD
Celera1235,318,582 - 235,397,159 (+)NCBI
RefSeq Acc Id: XM_017589665   ⟹   XP_017445154
Rat AssemblyChrPosition (strand)Source
mRatBN7.21239,425,515 - 239,552,323 (+)NCBI
Rnor_6.01259,692,020 - 259,809,045 (+)NCBI
Protein Sequences
Protein RefSeqs NP_072109 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445154 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53195 (Get FASTA)   NCBI Sequence Viewer  
  CAA75730 (Get FASTA)   NCBI Sequence Viewer  
  EDL94186 (Get FASTA)   NCBI Sequence Viewer  
  P97687 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_072109   ⟸   NM_022587
- UniProtKB: P97687 (UniProtKB/Swiss-Prot),   F1M0G3 (UniProtKB/TrEMBL),   A6JH62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445154   ⟸   XM_017589665
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000051602   ⟸   ENSRNOT00000054719
RefSeq Acc Id: ENSRNOP00000019751   ⟸   ENSRNOT00000019751
RefSeq Acc Id: ENSRNOP00000082116   ⟸   ENSRNOT00000115487
RefSeq Acc Id: ENSRNOP00000096959   ⟸   ENSRNOT00000115846

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A617-F1-model_v2 AlphaFold D4A617 1-465 view protein structure
AF-P97687-F1-model_v2 AlphaFold P97687 1-511 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69265 AgrOrtholog
BioCyc Gene G2FUF-55703 BioCyc
Ensembl Genes ENSRNOG00000014574 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000046546 Ensembl
Ensembl Protein ENSRNOP00000019751.6 UniProtKB/TrEMBL
  ENSRNOP00000051602.4 UniProtKB/TrEMBL
  ENSRNOP00000082116.1 UniProtKB/TrEMBL
  ENSRNOP00000096959.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019751.6 UniProtKB/TrEMBL
  ENSRNOT00000054719.5 UniProtKB/TrEMBL
  ENSRNOT00000115487.1 UniProtKB/TrEMBL
  ENSRNOT00000115846.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Exopolyphosphatase. Domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GDA1_CD39_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64519 UniProtKB/TrEMBL
  PTHR11782 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GDA1_CD39 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Entpd1 PhenoGen
  D4A617_RAT UniProtKB/TrEMBL
  ENTP1_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Entpd1  ectonucleoside triphosphate diphosphohydrolase 1  LOC103689954  ectonucleoside triphosphate diphosphohydrolase 1  Data Merged 737654 PROVISIONAL
2014-08-25 LOC103689954  ectonucleoside triphosphate diphosphohydrolase 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Entpd1  ectonucleoside triphosphate diphosphohydrolase 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog is associated with partial epilepsy with audiogenic symptoms 728666