Zfyve27 (zinc finger FYVE-type containing 27) - Rat Genome Database

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Gene: Zfyve27 (zinc finger FYVE-type containing 27) Rattus norvegicus
Analyze
Symbol: Zfyve27
Name: zinc finger FYVE-type containing 27
RGD ID: 735177
Description: Predicted to enable identical protein binding activity and protein self-association. Involved in neuron projection development; neurotrophin TRK receptor signaling pathway; and protein localization to plasma membrane. Located in growth cone membrane and recycling endosome membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 33. Orthologous to human ZFYVE27 (zinc finger FYVE-type containing 27); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC72597; protrudin; Unknown (protein for MGC:72597); zinc finger FYVE domain-containing protein 27; zinc finger, FYVE domain containing 27
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81250,929,110 - 250,952,481 (+)NCBIGRCr8
mRatBN7.21240,979,831 - 241,003,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,979,842 - 241,003,193 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1249,125,110 - 249,148,600 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01255,822,263 - 255,845,757 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01248,475,290 - 248,498,780 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01261,415,172 - 261,438,539 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1261,415,191 - 261,438,539 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01268,867,649 - 268,891,011 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41248,663,072 - 248,683,668 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11248,922,982 - 248,943,578 (-)NCBI
Celera1236,814,158 - 236,837,503 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Protrudin induces neurite formation by directional membrane trafficking. Shirane M and Nakayama KI, Science. 2006 Nov 3;314(5800):818-21.
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19289470   PMID:21976701   PMID:23969831   PMID:24251978   PMID:24668814   PMID:34348158  


Genomics

Comparative Map Data
Zfyve27
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81250,929,110 - 250,952,481 (+)NCBIGRCr8
mRatBN7.21240,979,831 - 241,003,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,979,842 - 241,003,193 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1249,125,110 - 249,148,600 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01255,822,263 - 255,845,757 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01248,475,290 - 248,498,780 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01261,415,172 - 261,438,539 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1261,415,191 - 261,438,539 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01268,867,649 - 268,891,011 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41248,663,072 - 248,683,668 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11248,922,982 - 248,943,578 (-)NCBI
Celera1236,814,158 - 236,837,503 (+)NCBICelera
Cytogenetic Map1q54NCBI
ZFYVE27
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381097,737,128 - 97,760,895 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1097,737,121 - 97,760,907 (+)EnsemblGRCh38hg38GRCh38
GRCh371099,496,885 - 99,520,652 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361099,486,875 - 99,510,642 (+)NCBINCBI36Build 36hg18NCBI36
Build 341099,486,874 - 99,510,642NCBI
Celera1093,234,147 - 93,257,930 (+)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1093,122,130 - 93,145,914 (+)NCBIHuRef
CHM1_11099,778,542 - 99,802,337 (+)NCBICHM1_1
T2T-CHM13v2.01098,617,284 - 98,641,047 (+)NCBIT2T-CHM13v2.0
Zfyve27
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391942,159,006 - 42,183,032 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1942,152,390 - 42,183,029 (+)EnsemblGRCm39 Ensembl
GRCm381942,170,567 - 42,194,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1942,163,951 - 42,194,590 (+)EnsemblGRCm38mm10GRCm38
MGSCv371942,245,057 - 42,269,083 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361942,223,932 - 42,247,904 (+)NCBIMGSCv36mm8
Celera1942,968,481 - 42,992,507 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1935.87NCBI
Zfyve27
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555073,808,389 - 3,833,708 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555073,808,885 - 3,833,708 (+)NCBIChiLan1.0ChiLan1.0
ZFYVE27
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28109,645,205 - 109,669,039 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110109,650,524 - 109,674,358 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01094,353,624 - 94,377,430 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11097,848,174 - 97,871,958 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1097,848,176 - 97,871,958 (+)Ensemblpanpan1.1panPan2
ZFYVE27
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12810,966,158 - 10,987,822 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2810,966,142 - 11,036,946 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2811,151,093 - 11,172,534 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02811,291,597 - 11,313,023 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2811,291,576 - 11,313,020 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12810,976,573 - 10,998,000 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02811,013,211 - 11,034,448 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02811,153,185 - 11,174,667 (+)NCBIUU_Cfam_GSD_1.0
Zfyve27
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721335,940,171 - 35,964,603 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366361,979,172 - 2,003,769 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366361,979,287 - 2,003,696 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFYVE27
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14109,088,810 - 109,113,011 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114109,088,758 - 109,119,854 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214118,592,893 - 118,617,131 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZFYVE27
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1990,900,747 - 90,925,944 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl990,901,292 - 90,925,944 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604851,801,318 - 51,825,785 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfyve27
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247379,367,756 - 9,390,243 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247379,367,817 - 9,415,089 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfyve27
100 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:432
Count of miRNA genes:218
Interacting mature miRNAs:263
Transcripts:ENSRNOT00000040740
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

Markers in Region
RH129707  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,000,222 - 241,000,409 (+)MAPPERmRatBN7.2
Rnor_6.01261,435,569 - 261,435,755NCBIRnor6.0
Rnor_5.01268,888,041 - 268,888,227UniSTSRnor5.0
RGSC_v3.41248,663,138 - 248,663,324UniSTSRGSC3.4
Celera1236,834,533 - 236,834,719UniSTS
RH 3.4 Map11620.71UniSTS
Cytogenetic Map1q54UniSTS
RH129858  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,002,920 - 241,003,103 (+)MAPPERmRatBN7.2
Rnor_6.01261,438,267 - 261,438,449NCBIRnor6.0
Rnor_5.01268,890,739 - 268,890,921UniSTSRnor5.0
RGSC_v3.41248,660,444 - 248,660,626UniSTSRGSC3.4
Celera1236,837,231 - 236,837,413UniSTS
RH 3.4 Map11620.71UniSTS
Cytogenetic Map1q54UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 9 15 72 22 29 11
Low 43 48 41 4 41 8 11 2 13 12 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000040740   ⟹   ENSRNOP00000051399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1240,979,842 - 241,000,472 (+)Ensembl
Rnor_6.0 Ensembl1261,415,200 - 261,434,720 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083287   ⟹   ENSRNOP00000074613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1240,979,844 - 241,003,193 (+)Ensembl
Rnor_6.0 Ensembl1261,415,191 - 261,438,539 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107917   ⟹   ENSRNOP00000094645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1240,985,270 - 241,003,193 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114879   ⟹   ENSRNOP00000093987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1240,980,058 - 241,003,193 (+)Ensembl
RefSeq Acc Id: NM_199104   ⟹   NP_954535
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81250,929,131 - 250,952,481 (+)NCBI
mRatBN7.21240,979,844 - 241,003,193 (+)NCBI
Rnor_6.01261,415,191 - 261,438,539 (+)NCBI
Rnor_5.01268,867,649 - 268,891,011 (+)NCBI
RGSC_v3.41248,663,072 - 248,683,668 (-)RGD
Celera1236,814,158 - 236,837,503 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231392   ⟹   XP_006231454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81250,929,110 - 250,952,481 (+)NCBI
mRatBN7.21240,979,831 - 241,003,193 (+)NCBI
Rnor_6.01261,415,172 - 261,438,533 (+)NCBI
Rnor_5.01268,867,649 - 268,891,011 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080096   ⟹   XP_038936024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81250,929,110 - 250,941,591 (+)NCBI
mRatBN7.21240,979,831 - 240,992,303 (+)NCBI
RefSeq Acc Id: XM_063264672   ⟹   XP_063120742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81250,929,110 - 250,948,319 (+)NCBI
RefSeq Acc Id: XM_063264673   ⟹   XP_063120743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81250,929,110 - 250,948,314 (+)NCBI
RefSeq Acc Id: XM_063264677   ⟹   XP_063120747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81250,930,090 - 250,948,334 (+)NCBI
RefSeq Acc Id: XM_063264680   ⟹   XP_063120750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81250,940,939 - 250,948,369 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_954535   ⟸   NM_199104
- UniProtKB: Q6P7B7 (UniProtKB/Swiss-Prot),   A0A8I6AJX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231454   ⟸   XM_006231392
- Peptide Label: isoform X3
- UniProtKB: A0A140TAG8 (UniProtKB/TrEMBL),   A0A8I6AJX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074613   ⟸   ENSRNOT00000083287
RefSeq Acc Id: ENSRNOP00000051399   ⟸   ENSRNOT00000040740
RefSeq Acc Id: XP_038936024   ⟸   XM_039080096
- Peptide Label: isoform X5
- UniProtKB: A6JHB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093987   ⟸   ENSRNOT00000114879
RefSeq Acc Id: ENSRNOP00000094645   ⟸   ENSRNOT00000107917
RefSeq Acc Id: XP_063120742   ⟸   XM_063264672
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120743   ⟸   XM_063264673
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063120747   ⟸   XM_063264677
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063120750   ⟸   XM_063264680
- Peptide Label: isoform X6
Protein Domains
FYVE-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P7B7-F1-model_v2 AlphaFold Q6P7B7 1-404 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690917
Promoter ID:EPDNEW_R1442
Type:initiation region
Name:Zfyve27_1
Description:zinc finger FYVE-type containing 27
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01261,415,184 - 261,415,244EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735177 AgrOrtholog
BioCyc Gene G2FUF-55653 BioCyc
Ensembl Genes ENSRNOG00000014903 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040740.5 UniProtKB/TrEMBL
  ENSRNOT00000083287 ENTREZGENE
  ENSRNOT00000083287.2 UniProtKB/Swiss-Prot
  ENSRNOT00000107917.1 UniProtKB/TrEMBL
  ENSRNOT00000114879.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599023 IMAGE-MGC_LOAD
InterPro Protrudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:309376 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72597 IMAGE-MGC_LOAD
NCBI Gene 309376 ENTREZGENE
PANTHER PROTRUDIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14543 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zfyve27 PhenoGen
PROSITE ZF_FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014903 RatGTEx
SMART FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAG8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJX0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMM0_RAT UniProtKB/TrEMBL
  A6JHB0 ENTREZGENE, UniProtKB/TrEMBL
  Q6P7B7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-19 Zfyve27  zinc finger FYVE-type containing 27  Zfyve27  zinc finger, FYVE domain containing 27  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Zfyve27  zinc finger, FYVE domain containing 27    Unknown (protein for MGC:72597)  Name updated 1299863 APPROVED
2004-09-10 Zfyve27  Unknown (protein for MGC:72597)  MGC72597    Symbol and Name updated 1299863 APPROVED