Hpse2 (heparanase 2 (inactive)) - Rat Genome Database

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Gene: Hpse2 (heparanase 2 (inactive)) Rattus norvegicus
Analyze
Symbol: Hpse2
Name: heparanase 2 (inactive)
RGD ID: 1307959
Description: Predicted to enable heparan sulfate proteoglycan binding activity. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell population proliferation. Predicted to be located in extracellular matrix. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human HPSE2 (heparanase 2 (inactive)); PARTICIPATES IN glycosaminoglycan degradation pathway; INTERACTS WITH bisphenol A; 15-acetyldeoxynivalenol (ortholog); 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: heparanase 2; heparanase-2; inactive heparanase-2; LOC108349826; LOC293955; LOC368128; similar to Heparanase-2 (Hpa2); uncharacterized LOC108349826
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21241,582,904 - 242,284,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,583,187 - 242,246,118 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1249,730,681 - 250,396,023 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01256,427,848 - 257,093,195 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01249,080,851 - 249,746,182 (-)NCBIRnor_WKY
Rnor_6.01262,020,903 - 263,138,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01270,576,436 - 270,580,047 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01269,475,568 - 270,128,189 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41247,458,939 - 248,100,231 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11247,958,907 - 247,971,603 (+)NCBI
Celera1237,417,175 - 238,067,548 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20576607   PMID:21873635   PMID:25510506  


Genomics

Comparative Map Data
Hpse2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21241,582,904 - 242,284,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,583,187 - 242,246,118 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1249,730,681 - 250,396,023 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01256,427,848 - 257,093,195 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01249,080,851 - 249,746,182 (-)NCBIRnor_WKY
Rnor_6.01262,020,903 - 263,138,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01270,576,436 - 270,580,047 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01269,475,568 - 270,128,189 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41247,458,939 - 248,100,231 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11247,958,907 - 247,971,603 (+)NCBI
Celera1237,417,175 - 238,067,548 (-)NCBICelera
Cytogenetic Map1q54NCBI
HPSE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381098,457,077 - 99,315,951 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1098,457,077 - 99,235,862 (-)EnsemblGRCh38hg38GRCh38
GRCh3710100,216,834 - 100,995,632 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610100,208,867 - 100,985,609 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410100,208,864 - 100,985,609NCBI
Celera1093,953,460 - 94,732,450 (-)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1094,130,091 - 94,622,164 (-)NCBIHuRef
HuRef1093,841,617 - 94,106,699 (-)NCBIHuRef
CHM1_110100,498,701 - 101,277,572 (-)NCBICHM1_1
T2T-CHM13v2.01099,337,053 - 100,117,425 (-)NCBIT2T-CHM13v2.0
Hpse2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391942,774,980 - 43,376,913 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1942,774,978 - 43,376,794 (-)EnsemblGRCm39 Ensembl
GRCm381942,786,541 - 43,388,476 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1942,786,539 - 43,388,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv371942,863,085 - 43,462,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361942,841,906 - 43,441,622 (-)NCBIMGSCv36mm8
MGSCv361942,676,998 - 43,277,483 (-)NCBIMGSCv36mm8
Celera1943,584,218 - 44,179,795 (-)NCBICelera
Cytogenetic Map19C3NCBI
Hpse2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555074,445,772 - 5,205,957 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555074,442,677 - 5,205,976 (-)NCBIChiLan1.0ChiLan1.0
HPSE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11098,566,705 - 99,344,205 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1098,592,019 - 99,344,132 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01095,071,571 - 95,851,896 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HPSE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12811,584,440 - 12,215,732 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2811,585,807 - 12,215,614 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2811,766,981 - 12,399,809 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02811,909,883 - 12,161,577 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2811,912,217 - 12,683,674 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12811,593,608 - 12,230,470 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02811,630,471 - 12,261,439 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02811,770,213 - 12,402,804 (-)NCBIUU_Cfam_GSD_1.0
Hpse2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721334,735,574 - 35,362,965 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936636774,778 - 1,399,702 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936636774,705 - 1,402,009 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPSE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14109,764,170 - 110,469,141 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114109,764,511 - 110,469,064 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214119,262,145 - 119,752,959 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103216367
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1991,616,277 - 92,346,206 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604852,670,244 - 52,785,944 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hpse2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473710,058,787 - 10,976,525 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473710,055,408 - 10,976,525 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hpse2
2751 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:58
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000067274
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

Markers in Region
D1Mgh32  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,799,011 - 241,799,120 (+)MAPPERmRatBN7.2
Rnor_6.01262,433,584 - 262,433,692NCBIRnor6.0
Rnor_6.01262,237,344 - 262,237,452NCBIRnor6.0
Rnor_5.01269,885,719 - 269,885,827UniSTSRnor5.0
Rnor_5.01269,689,479 - 269,689,587UniSTSRnor5.0
RGSC_v3.41247,882,276 - 247,882,384UniSTSRGSC3.4
RGSC_v3.41247,882,275 - 247,882,384RGDRGSC3.4
RGSC_v3.11247,996,750 - 247,996,859RGD
Celera1237,630,552 - 237,630,660UniSTS
Cytogenetic Map1q54UniSTS
D1Rat145  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01269,901,560 - 269,901,692NCBIRnor5.0
Rnor_5.01269,705,321 - 269,705,453NCBIRnor5.0
Rnor_5.01269,705,321 - 269,705,541NCBIRnor5.0
Rnor_5.01269,901,560 - 269,901,780NCBIRnor5.0
Rnor_5.01269,705,321 - 269,705,542NCBIRnor5.0
Rnor_5.01269,901,560 - 269,901,781NCBIRnor5.0
RGSC_v3.41247,866,323 - 247,866,542UniSTSRGSC3.4
RGSC_v3.41247,866,411 - 247,866,542UniSTSRGSC3.4
RGSC_v3.41247,866,322 - 247,866,542RGDRGSC3.4
RGSC_v3.11247,980,743 - 247,981,217RGD
Celera1237,646,394 - 237,646,509UniSTS
SHRSP x BN Map1135.6499UniSTS
SHRSP x BN Map1135.6499RGD
FHH x ACI Map1128.0699RGD
Cytogenetic Map1q54UniSTS
BE116307  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,808,118 - 241,808,289 (+)MAPPERmRatBN7.2
Rnor_6.01262,442,691 - 262,442,861NCBIRnor6.0
Rnor_6.01262,246,451 - 262,246,621NCBIRnor6.0
Rnor_5.01269,894,826 - 269,894,996UniSTSRnor5.0
Rnor_5.01269,698,586 - 269,698,756UniSTSRnor5.0
RGSC_v3.41247,873,107 - 247,873,277UniSTSRGSC3.4
Celera1237,639,659 - 237,639,829UniSTS
RH 3.4 Map11619.5UniSTS
Cytogenetic Map1q54UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000098280   ⟹   ENSRNOP00000095495
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,583,187 - 242,246,118 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106483   ⟹   ENSRNOP00000091065
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,583,187 - 242,246,118 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114692   ⟹   ENSRNOP00000085923
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,583,187 - 242,246,118 (-)Ensembl
RefSeq Acc Id: NM_001135762   ⟹   NP_001129234
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21241,585,398 - 242,245,912 (-)NCBI
Rnor_6.01262,023,397 - 263,134,871 (-)NCBI
Rnor_5.01269,475,568 - 270,128,189 (-)NCBI
Rnor_5.01270,576,436 - 270,580,047 (-)NCBI
RGSC_v3.41247,458,939 - 248,100,231 (+)RGD
Celera1237,417,175 - 238,067,548 (-)RGD
Sequence:
RefSeq Acc Id: XM_008760445   ⟹   XP_008758667
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21241,582,904 - 242,258,007 (-)NCBI
Rnor_6.01262,020,903 - 263,138,299 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085865   ⟹   XP_038941793
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21241,582,904 - 242,284,348 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001129234 (Get FASTA)   NCBI Sequence Viewer  
  XP_008758667 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941793 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94247 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001129234   ⟸   NM_001135762
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_008758667   ⟸   XM_008760445
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AN52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038941793   ⟸   XM_039085865
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000091065   ⟸   ENSRNOT00000106483
RefSeq Acc Id: ENSRNOP00000085923   ⟸   ENSRNOT00000114692
RefSeq Acc Id: ENSRNOP00000095495   ⟸   ENSRNOT00000098280

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307959 AgrOrtholog
BioCyc Gene G2FUF-55630 BioCyc
Ensembl Genes ENSRNOG00000064037 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000085923.1 UniProtKB/TrEMBL
  ENSRNOP00000091065.1 UniProtKB/TrEMBL
  ENSRNOP00000095495 ENTREZGENE
  ENSRNOP00000095495.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000098280 ENTREZGENE
  ENSRNOT00000098280.1 UniProtKB/TrEMBL
  ENSRNOT00000106483.1 UniProtKB/TrEMBL
  ENSRNOT00000114692.1 UniProtKB/TrEMBL
InterPro Glyco_hydro_79 UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
NCBI Gene 368128 ENTREZGENE
Pfam Glyco_hydro_79n UniProtKB/TrEMBL
PhenoGen Hpse2 PhenoGen
Superfamily-SCOP SSF51445 UniProtKB/TrEMBL
UniProt A0A8I6A4V5_RAT UniProtKB/TrEMBL
  A0A8I6AN52 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APR5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hpse2  heparanase 2 (inactive)  LOC108349826  uncharacterized LOC108349826  Data Merged 737654 PROVISIONAL
2016-08-02 LOC108349826  uncharacterized LOC108349826      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-06-09 Hpse2  heparanase 2 (inactive)  Hpse2  heparanase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-01-20 Hpse2  heparanase 2   LOC368128  similar to Heparanase-2 (Hpa2)  Data Merged 737654 APPROVED
2008-04-30 Hpse2  heparanase 2   Hpse2_predicted  heparanase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC368128  similar to Heparanase-2 (Hpa2)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Hpse2_predicted  heparanase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED