Gfra1 (GDNF family receptor alpha 1) - Rat Genome Database

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Gene: Gfra1 (GDNF family receptor alpha 1) Rattus norvegicus
Analyze
Symbol: Gfra1 (Ensembl: AABR07007068.1)
Name: GDNF family receptor alpha 1
RGD ID: 2681
Description: Enables integrin binding activity and neurotrophin receptor activity. Involved in several processes, including aging; male gonad development; and positive regulation of peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Part of plasma membrane protein complex and receptor complex. Used to study Parkinsonism. Biomarker of Parkinsonism; brain ischemia; and sciatic neuropathy. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human GFRA1 (GDNF family receptor alpha 1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GDNF family receptor alpha-1; GDNF family receptor alpha-1-like; GDNF receptor alpha; GDNF receptor alpha-1; GDNFR-alpha; GDNFR-alpha-1; GFR-alpha-1; glial cell line derived neurotrophic factor family receptor alpha 1; Glial cell line-derived neurotrophic factor receptor alpha; LOC100911751; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21257,315,682 - 257,552,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1257,321,742 - 257,551,473 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1265,542,982 - 265,775,408 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01272,248,912 - 272,481,436 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01264,892,893 - 265,124,304 (-)NCBIRnor_WKY
Rnor_6.01279,203,046 - 279,572,789 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01286,932,096 - 286,934,801 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01286,571,283 - 286,640,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41264,614,329 - 264,875,486 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11264,825,373 - 265,086,531 (-)NCBI
Celera1253,001,051 - 253,229,417 (-)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,1,1-trichloroethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
cisplatin  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endrin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
fulvestrant  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
GW 4064  (ISO)
L-ascorbic acid  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (EXP,ISO)
Muraglitazar  (EXP)
naproxen  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (EXP)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
resmethrin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
stigmasterol  (ISO)
sumatriptan  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Up-regulation of GDNFR-alpha and c-ret mRNA in facial motor neurons following facial nerve injury in the rat. Burazin TC and Gundlach AL, Brain Res Mol Brain Res. 1998 Apr;55(2):331-6.
2. Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor. Cao JP, etal., J Comp Neurol. 2008 Jul 10;509(2):203-10.
3. Glial cell line-derived neurotrophic factor promotes olfactory ensheathing cells migration. Cao L, etal., Glia. 2006 Nov 1;54(6):536-44.
4. Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Carmillo P, etal., Biochemistry. 2005 Feb 22;44(7):2545-54.
5. Expression of GFRalpha1 receptor splicing variants with different biochemical properties is modulated during kidney development. Charlet-Berguerand N, etal., Cell Signal. 2004 Dec;16(12):1425-34.
6. Down-regulation of GFRalpha-1 expression by antisense oligodeoxynucleotide attenuates electroacupuncture analgesia on heat hyperalgesia in a rat model of neuropathic pain. Dong ZQ, etal., Brain Res Bull. 2006 Mar 15;69(1):30-6. Epub 2005 Nov 28.
7. Distinct structural elements in GDNF mediate binding to GFRalpha1 and activation of the GFRalpha1-c-Ret receptor complex. Eketjäll S, etal., EMBO J. 1999 Nov 1;18(21):5901-10.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET. Glerup S, etal., Cell Rep. 2013 Jan 31;3(1):186-99. doi: 10.1016/j.celrep.2012.12.011. Epub 2013 Jan 17.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Characterization of glial cell line-derived neurotrophic factor family receptor alpha-1 in peripheral nerve Schwann cells. Hase A, etal., J Neurochem. 2005 Oct;95(2):537-43. Epub 2005 Aug 8.
12. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Jing S, etal., Cell 1996 Jun 28;85(7):1113-24.
13. Developmental expression of glial cell-line derived neurotrophic factor, neurturin, and their receptor mRNA in the rat urinary bladder. Kawakami T, etal., Neurourol Urodyn 2003;22(1):83-8.
14. Sciatic nerve injury in adult rats causes distinct changes in the central projections of sensory neurons expressing different glial cell line-derived neurotrophic factor family receptors. Keast JR, etal., J Comp Neurol. 2010 Aug 1;518(15):3024-45.
15. Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats. Kitagawa H, etal., Brain Res. 1999 Jul 10;834(1-2):190-5.
16. Regulation of GDNF and its receptor components GFR-alpha1, -alpha2 and Ret during development and in the mature retino-collicular pathway. Kretz A, etal., Brain Res. 2006 May 23;1090(1):1-14. Epub 2006 May 2.
17. Signaling of glial cell line-derived neurotrophic factor and its receptor GFRalpha1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson disease. Lei Z, etal., J Neuropathol Exp Neurol. 2011 Sep;70(9):736-47.
18. GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection. Lindqvist N, etal., Exp Neurol. 2004 Jun;187(2):487-99.
19. Gene Expression Profiling of Rat Testis Development During the Early Post-Natal Stages. Liu T, etal., Reprod Domest Anim. 2011 Nov 24. doi: 10.1111/j.1439-0531.2011.01950.x.
20. Regulation of c-Ret, GFRalpha1, and GFRalpha2 in the substantia nigra pars compacta in a rat model of Parkinson's disease. Marco S, etal., J Neurobiol. 2002 Sep 15;52(4):343-51.
21. Immunohistochemical expression of two members of the GDNF family of growth factors and their receptors in the olfactory system. Maroldt H, etal., J Neurocytol. 2005 Sep;34(3-5):241-55. Epub 2006 Jul 13.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. GFR alpha-1 receptor expression in the aging nigrostriatal and mesoaccumbens pathways. Pruett BS and Salvatore MF, J Neurochem. 2010 Nov;115(3):707-15. doi: 10.1111/j.1471-4159.2010.06963.x. Epub 2010 Sep 28.
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Sanicola M, etal., Proc Natl Acad Sci U S A 1997 Jun 10;94(12):6238-43.
29. Time course study of GFRalpha-1 expression in an animal model of stroke. Sarabi A, etal., Exp Neurol. 2001 Aug;170(2):283-9.
30. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
31. Discordant expression of c-Ret and glial cell line-derived neurotrophic factor receptor alpha-1 mRNAs in response to motor nerve injury in neonate rats. Tsujino H, etal., Brain Res Mol Brain Res. 1999 Jul 5;70(2):298-303.
32. Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Uesaka T, etal., Development. 2007 Jun;134(11):2171-81.
33. Expression of glial cell line-derived neurotrophic factor and GDNFR-alpha mRNAs in human peripheral neuropathies. Yamamoto M, etal., Brain Res. 1998 Nov 2;809(2):175-81.
34. [The expression of glial cell derived neurotrophic factor and its receptor GDNFR-alpha and GDNFR-beta mRNA in spinal cord, brainstem and frontal cortex during morphine withdrawal in rats] Zhou W, etal., Zhonghua Yi Xue Za Zhi 2000 Feb;80(2):135-9.
Additional References at PubMed
PMID:8657309   PMID:9192898   PMID:10719212   PMID:11069590   PMID:12535958   PMID:14563851   PMID:15044950   PMID:15225646   PMID:15306125   PMID:16289634   PMID:16513266   PMID:17240430  
PMID:17298301   PMID:17538205   PMID:17640046   PMID:18085594   PMID:18845535   PMID:19056867   PMID:19845157   PMID:20350599   PMID:20807316   PMID:21133924   PMID:22266674   PMID:23321789  
PMID:23767459   PMID:25043933   PMID:26599339   PMID:30541958  


Genomics

Comparative Map Data
Gfra1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21257,315,682 - 257,552,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1257,321,742 - 257,551,473 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1265,542,982 - 265,775,408 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01272,248,912 - 272,481,436 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01264,892,893 - 265,124,304 (-)NCBIRnor_WKY
Rnor_6.01279,203,046 - 279,572,789 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01286,932,096 - 286,934,801 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01286,571,283 - 286,640,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41264,614,329 - 264,875,486 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11264,825,373 - 265,086,531 (-)NCBI
Celera1253,001,051 - 253,229,417 (-)NCBICelera
Cytogenetic Map1q55NCBI
GFRA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810116,056,925 - 116,274,705 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10116,056,925 - 116,276,803 (-)EnsemblGRCh38hg38GRCh38
GRCh3710117,816,436 - 118,034,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610117,812,943 - 118,022,966 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410117,813,264 - 118,022,966NCBI
Celera10111,545,807 - 111,762,346 (-)NCBICelera
Cytogenetic Map10q25.3NCBI
HuRef10111,444,080 - 111,660,347 (-)NCBIHuRef
CHM1_110118,099,661 - 118,316,231 (-)NCBICHM1_1
T2T-CHM13v2.010116,951,015 - 117,168,680 (-)NCBIT2T-CHM13v2.0
Gfra1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391958,224,013 - 58,444,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1958,224,036 - 58,444,341 (-)EnsemblGRCm39 Ensembl
GRCm381958,235,581 - 58,455,946 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1958,235,604 - 58,455,909 (-)EnsemblGRCm38mm10GRCm38
MGSCv371958,311,182 - 58,528,956 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361958,289,942 - 58,507,716 (-)NCBIMGSCv36mm8
Celera1960,429,999 - 60,650,471 (-)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1954.18NCBI
Gfra1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543120,866,685 - 21,070,853 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543120,859,152 - 21,070,886 (-)NCBIChiLan1.0ChiLan1.0
GFRA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110116,079,056 - 116,295,195 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10116,079,063 - 116,295,164 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010112,645,574 - 112,862,413 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GFRA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12826,707,592 - 26,910,029 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2826,709,645 - 26,909,992 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2826,859,169 - 27,062,134 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02827,243,451 - 27,446,937 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2827,243,342 - 27,446,257 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12826,799,655 - 27,002,551 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02826,812,101 - 27,015,351 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02827,006,585 - 27,209,685 (-)NCBIUU_Cfam_GSD_1.0
Gfra1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721319,299,126 - 19,490,965 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364866,071,023 - 6,262,165 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364866,066,108 - 6,262,055 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GFRA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14126,277,875 - 126,499,465 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114126,273,558 - 126,499,957 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214137,525,348 - 137,748,038 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GFRA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19108,869,444 - 109,088,803 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9108,876,855 - 109,087,488 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604870,112,995 - 70,332,336 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gfra1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473730,324,515 - 30,526,486 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473730,325,962 - 30,526,311 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gfra1
1462 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:331
Count of miRNA genes:200
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000023667, ENSRNOT00000066428
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1245907761257976495Rat

Markers in Region
RH132446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21257,424,447 - 257,424,659 (+)MAPPERmRatBN7.2
Rnor_6.01279,415,771 - 279,415,982NCBIRnor6.0
Rnor_6.01279,311,075 - 279,311,286NCBIRnor6.0
Rnor_5.01286,777,918 - 286,778,129UniSTSRnor5.0
Rnor_5.01286,673,222 - 286,673,433UniSTSRnor5.0
RGSC_v3.41264,747,990 - 264,748,201UniSTSRGSC3.4
Celera1253,102,980 - 253,103,191UniSTS
RH 3.4 Map11689.5UniSTS
Cytogenetic Map1q55UniSTS
AW529053  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21257,320,279 - 257,320,473 (+)MAPPERmRatBN7.2
Rnor_6.01279,207,644 - 279,207,837NCBIRnor6.0
Rnor_5.01286,571,341 - 286,571,534UniSTSRnor5.0
RGSC_v3.41264,614,387 - 264,614,580UniSTSRGSC3.4
Celera1253,001,109 - 253,001,302UniSTS
RH 3.4 Map11690.1UniSTS
Cytogenetic Map1q55UniSTS
Gfra1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21257,549,390 - 257,550,528 (+)MAPPERmRatBN7.2
Rnor_6.01279,571,144 - 279,572,281NCBIRnor6.0
Rnor_6.01278,478,808 - 278,479,945NCBIRnor6.0
Rnor_5.01285,849,673 - 285,850,810UniSTSRnor5.0
Rnor_5.01286,933,409 - 286,934,546UniSTSRnor5.0
RGSC_v3.41264,874,094 - 264,875,231UniSTSRGSC3.4
Celera1253,228,025 - 253,229,162UniSTS
Cytogenetic Map1q55UniSTS
Gfra1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21257,549,390 - 257,550,527 (+)MAPPERmRatBN7.2
Rnor_6.01279,571,144 - 279,572,280NCBIRnor6.0
Rnor_6.01278,478,808 - 278,479,944NCBIRnor6.0
Rnor_5.01285,849,673 - 285,850,809UniSTSRnor5.0
Rnor_5.01286,933,409 - 286,934,545UniSTSRnor5.0
RGSC_v3.41264,874,094 - 264,875,230UniSTSRGSC3.4
Celera1253,228,025 - 253,229,161UniSTS
Cytogenetic Map1q55UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023667   ⟹   ENSRNOP00000023667
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1257,321,742 - 257,551,473 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104357   ⟹   ENSRNOP00000091515
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1257,321,742 - 257,551,473 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119102   ⟹   ENSRNOP00000091664
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1257,321,742 - 257,551,473 (-)Ensembl
RefSeq Acc Id: NM_012959   ⟹   NP_037091
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21257,320,222 - 257,550,783 (-)NCBI
Rnor_6.01279,207,586 - 279,572,536 (-)NCBI
Rnor_5.01286,571,283 - 286,640,993 (-)NCBI
Rnor_5.01286,932,096 - 286,934,801 (-)NCBI
RGSC_v3.41264,614,329 - 264,875,486 (-)RGD
Celera1253,001,051 - 253,229,417 (-)RGD
Sequence:
RefSeq Acc Id: XM_008760512   ⟹   XP_008758734
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21257,315,682 - 257,551,042 (-)NCBI
Rnor_6.01279,203,046 - 279,572,789 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760514   ⟹   XP_008758736
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21257,315,682 - 257,551,498 (-)NCBI
Rnor_6.01279,203,046 - 279,572,595 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101759   ⟹   XP_038957687
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21257,315,682 - 257,551,498 (-)NCBI
RefSeq Acc Id: XM_039101762   ⟹   XP_038957690
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21257,315,682 - 257,551,523 (-)NCBI
RefSeq Acc Id: XM_039101768   ⟹   XP_038957696
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21257,315,682 - 257,552,004 (-)NCBI
RefSeq Acc Id: XM_039101773   ⟹   XP_038957701
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21257,315,682 - 257,551,280 (-)NCBI
RefSeq Acc Id: XM_039101776   ⟹   XP_038957704
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21257,315,682 - 257,551,081 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037091   ⟸   NM_012959
- Peptide Label: precursor
- UniProtKB: Q62997 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008758734   ⟸   XM_008760512
- Peptide Label: isoform X1
- UniProtKB: Q62997 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008758736   ⟸   XM_008760514
- Peptide Label: isoform X2
- UniProtKB: O35748 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038957696   ⟸   XM_039101768
- Peptide Label: isoform X1
- UniProtKB: Q62997 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957690   ⟸   XM_039101762
- Peptide Label: isoform X1
- UniProtKB: Q62997 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957687   ⟸   XM_039101759
- Peptide Label: isoform X1
- UniProtKB: Q62997 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957701   ⟸   XM_039101773
- Peptide Label: isoform X1
- UniProtKB: Q62997 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957704   ⟸   XM_039101776
- Peptide Label: isoform X1
- UniProtKB: Q62997 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000023667   ⟸   ENSRNOT00000023667
RefSeq Acc Id: ENSRNOP00000091664   ⟸   ENSRNOT00000119102
RefSeq Acc Id: ENSRNOP00000091515   ⟸   ENSRNOT00000104357
Protein Domains
GDNF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0A0MXY7-F1-model_v2 AlphaFold A0A0A0MXY7 1-343 view protein structure
AF-Q62997-F1-model_v2 AlphaFold Q62997 1-468 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2681 AgrOrtholog
BioCyc Gene G2FUF-55276 BioCyc
Ensembl Genes ENSRNOG00000017438 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023667.6 UniProtKB/TrEMBL
  ENSRNOP00000091515 ENTREZGENE
  ENSRNOP00000091515.1 UniProtKB/TrEMBL
  ENSRNOP00000091664 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023667.8 UniProtKB/TrEMBL
  ENSRNOT00000104357 ENTREZGENE
  ENSRNOT00000104357.1 UniProtKB/TrEMBL
  ENSRNOT00000119102 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GDNF/GAS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDNF_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDNF_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDNF_rcpt_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glial_neurotroph_fac_rcpt_a1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25454 UniProtKB/Swiss-Prot
NCBI Gene 25454 ENTREZGENE
PANTHER PTHR10269 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GDNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gfra1 PhenoGen
PIRSF GDNF_family_receptor_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GDNFRALPHA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDNFRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GDNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF110035 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218224
  TC227846
UniProt A0A0A0MXY7_RAT UniProtKB/TrEMBL
  GFRA1_RAT UniProtKB/Swiss-Prot
  O35748 ENTREZGENE, UniProtKB/TrEMBL
  Q62997 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gfra1  GDNF family receptor alpha 1  LOC100911751  GDNF family receptor alpha-1-like  Data Merged 737654 PROVISIONAL
2012-07-05 LOC100911751  GDNF family receptor alpha-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-10-17 Gfra1  GDNF family receptor alpha 1  Gfra1  glial cell line derived neurotrophic factor family receptor alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Gfra1  glial cell line derived neurotrophic factor family receptor alpha 1    Glial cell line-derived neurotrophic factor receptor alpha  Name updated 625702 APPROVED
2002-06-10 Gfra1  Glial cell line-derived neurotrophic factor receptor alpha      Symbol and Name status set to approved 70586 APPROVED