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Gene: Gfra1 (GDNF family receptor alpha 1) Rattus norvegicus
Symbol: Gfra1
Name: GDNF family receptor alpha 1
RGD ID: 2681
Description: Exhibits integrin binding activity and neurotrophin receptor activity. Involved in several processes, including male gonad development; neuron projection development; and positive regulation of peptidyl-tyrosine phosphorylation. Localizes to several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Biomarker of brain ischemia and sciatic neuropathy. Orthologous to human GFRA1 (GDNF family receptor alpha 1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: GDNF family receptor alpha-1; GDNF receptor alpha; GDNF receptor alpha-1; GDNFR-alpha; GDNFR-alpha-1; GFR-alpha-1; glial cell line derived neurotrophic factor family receptor alpha 1; Glial cell line-derived neurotrophic factor receptor alpha; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1
Homo sapiens (human) : GFRA1 (GDNF family receptor alpha 1)  HGNC  Alliance
Mus musculus (house mouse) : Gfra1 (glial cell line derived neurotrophic factor family receptor alpha 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gfra1 (GDNF family receptor alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GFRA1 (GDNF family receptor alpha 1)
Canis lupus familiaris (dog) : GFRA1 (GDNF family receptor alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gfra1 (GDNF family receptor alpha 1)
Sus scrofa (pig) : GFRA1 (GDNF family receptor alpha 1)
Chlorocebus sabaeus (African green monkey) : GFRA1 (GDNF family receptor alpha 1)
Heterocephalus glaber (naked mole-rat) : Gfra1 (GDNF family receptor alpha 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01279,203,046 - 279,572,789 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01286,571,283 - 286,640,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01286,932,096 - 286,934,801 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41264,614,329 - 264,875,486 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11264,825,373 - 265,086,531 (-)NCBI
Celera1253,001,051 - 253,229,417 (-)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Gfra1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2681
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.