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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2681
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gfra1
Name: GDNF family receptor alpha 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gfra1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of GFRA1 mRNAPMID:22298810
Gfra1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of GFRA1 mRNAPMID:23238561
Gfra1affects expressionISOGfra1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of GFRA1 mRNAPMID:26377647
Gfra1affects expressionISOGFRA1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of GFRA1 mRNAPMID:22298810
Gfra1decreases expressionISOGfra1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of GFRA1 mRNAPMID:19770486 PMID:23238561 PMID:26290441
Gfra1decreases expressionISOGFRA1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of GFRA1 mRNAPMID:19619570
Gfra1increases expressionISOGFRA1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of GFRA1 mRNAPMID:21296121
Gfra1multiple interactionsISOGfra1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin affects the methylation of GFRA1 intron] which results in increased expression of GFRA1 mRNA; [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of GFRA1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of GFRA1 mRNAPMID:16214954 PMID:25975270 PMID:33017471
Gfra1multiple interactionsISOGFRA1 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GFRA1 mRNAPMID:19619570
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