RGD Reference Report - Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats. - Rat Genome Database

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Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats.

Authors: Kitagawa, H  Sasaki, C  Zhang, WR  Sakai, K  Shiro, Y  Warita, H  Mitsumoto, Y  Mori, T  Abe, K 
Citation: Kitagawa H, etal., Brain Res. 1999 Jul 10;834(1-2):190-5.
RGD ID: 6218981
Pubmed: PMID:10407114   (View Abstract at PubMed)

In an attempt to elucidate whether glial cell line-derived neurotrophic factor (GDNF) receptors are induced after ischemic brain injury, possible expression of immunoreactive GDNF receptor-alpha1 (GFRalpha-1) and c-ret (RET) was examined at 3, 8, or 24 h after permanent middle cerebral artery occlusion (MCAO) in rats. Immunohistochemical study showed that both GFRalpha-1 and RET staining cells which were not detected in sham control brain, were present in the ipsilateral cortex and caudate at 3 to 8 h after permanent MCAO, and then decreased but remained to some extent at 24 h. Positive cells for both GDNF receptors were predominantly in cortical neurons of ischemic penumbral area. Western blot analysis confirmed the induction of those receptors after permanent MCAO. This rapid induction of GFRalpha-1 and RET, which correlates with the similar induction of GDNF under these conditions, may play a role in the early response to ischemic brain injury.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GFRA1Humanbrain ischemia  ISOGfra1 (Rattus norvegicus)protein:increased expression:cerebral cortexRGD 
Gfra1Ratbrain ischemia  IEP protein:increased expression:cerebral cortexRGD 
Gfra1Mousebrain ischemia  ISOGfra1 (Rattus norvegicus)protein:increased expression:cerebral cortexRGD 
RETHumanbrain ischemia  ISORet (Rattus norvegicus)protein:increased expression:cerebral cortexRGD 
RetRatbrain ischemia  IEP protein:increased expression:cerebral cortexRGD 
RetMousebrain ischemia  ISORet (Rattus norvegicus)protein:increased expression:cerebral cortexRGD 

Objects Annotated

Genes (Rattus norvegicus)
Gfra1  (GDNF family receptor alpha 1)
Ret  (ret proto-oncogene)

Genes (Mus musculus)
Gfra1  (glial cell line derived neurotrophic factor family receptor alpha 1)
Ret  (ret proto-oncogene)

Genes (Homo sapiens)
GFRA1  (GDNF family receptor alpha 1)
RET  (ret proto-oncogene)


Additional Information