Ret (ret proto-oncogene) - Rat Genome Database

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Gene: Ret (ret proto-oncogene) Rattus norvegicus
Analyze
Symbol: Ret
Name: ret proto-oncogene
RGD ID: 3556
Description: Predicted to enable calcium ion binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including innervation; positive regulation of neuron maturation; and retina development in camera-type eye. Located in several cellular components, including dendrite; early endosome; and neuronal cell body. Biomarker of Parkinsonism; brain ischemia; and pheochromocytoma. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (ret proto-oncogene); PARTICIPATES IN endocytosis pathway; thyroid cancer pathway; INTERACTS WITH (+)-pilocarpine; (-)-anisomycin; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: proto-oncogene tyrosine-protein kinase receptor Ret; receptor tyrosine kinase; Ret gene for receptor tyrosin; Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease); Ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Ept5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84152,998,344 - 153,040,556 (-)NCBIGRCr8
mRatBN7.24151,325,969 - 151,368,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4151,326,431 - 151,368,176 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4157,589,266 - 157,631,480 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04153,373,235 - 153,415,450 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04151,996,254 - 152,038,470 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04150,202,170 - 150,249,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,202,058 - 150,244,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04216,130,142 - 216,177,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,448,179 - 154,491,103 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14154,693,019 - 154,735,944 (-)NCBI
Celera4140,198,457 - 140,240,663 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
appendicitis  (ISO)
Brain Injuries  (IEP)
brain ischemia  (IEP)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Burkitt lymphoma  (ISO)
CAKUT  (ISO)
clubfoot  (ISS)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital central hypoventilation syndrome  (ISO)
Constipation  (ISO)
Deafness  (IEP)
diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  (ISO)
disease of cellular proliferation  (ISO)
Dwarfism  (ISO)
extraosseous Ewing sarcoma  (ISO)
Facial Nerve Injuries  (IEP)
Familial Amyloidosis  (ISO)
familial medullary thyroid carcinoma  (ISO)
genetic disease  (ISO)
gingival overgrowth  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hirschsprung Disease 1  (ISO)
Hirschsprung's disease  (ISO,ISS)
Hypertelorism  (ISO)
Hypoglossal Nerve Injuries  (IEP)
hypothyroidism  (ISO)
Islet Cell Tumor Syndrome  (ISO)
Joint Instability  (ISO)
Lymphatic Metastasis  (ISO)
Medullary Carcinomas  (ISO)
medullary thyroid carcinoma  (ISO)
medulloblastoma  (ISO)
megacolon  (ISO)
microcephaly  (ISO)
multiple endocrine neoplasia  (ISO)
multiple endocrine neoplasia type 1  (ISO)
multiple endocrine neoplasia type 2A  (ISO)
multiple endocrine neoplasia type 2B  (ISO,ISS)
multiple endocrine neoplasia type 4  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
papillary thyroid carcinoma  (ISO)
Parkinsonism  (IEP)
pheochromocytoma  (IEP,ISO,ISS)
pilocytic astrocytoma  (ISO)
renal agenesis  (ISO)
Renal Hypodysplasia/Aplasia 1  (ISO)
renal hypoplasia  (ISO)
status epilepticus  (ISO)
tetralogy of Fallot  (ISO)
thyroid gland carcinoma  (ISO)
Thyroid Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-anisomycin  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (EXP)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clomiphene  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cycloheximide  (EXP)
D-glucose  (EXP)
dabigatran  (EXP)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
diazinon  (EXP)
dichromium trioxide  (ISO)
diclofenac  (ISO)
dieldrin  (EXP,ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
endrin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
estrone  (ISO)
ethanol  (EXP,ISO)
fonofos  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
glucose  (EXP)
glyphosate  (ISO)
graphite  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
irbesartan  (ISO)
ivermectin  (ISO)
L-cysteine  (ISO)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese(II) chloride  (EXP)
Meclizine  (ISO)
medroxyprogesterone acetate  (ISO)
megestrol  (ISO)
mercury dibromide  (ISO)
mestranol  (ISO)
methapyrilene  (ISO)
Methazolamide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
mifepristone  (EXP)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
oxaliplatin  (EXP)
oxidopamine  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP)
parathion  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
picene  (ISO)
pinostrobin  (ISO)
ponatinib  (ISO)
propanal  (ISO)
Ptaquiloside  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
staurosporine  (EXP)
sulindac  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vandetanib  (ISO)
verapamil  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface receptor protein tyrosine kinase signaling pathway  (ISO)
cellular response to retinoic acid  (ISO)
embryonic epithelial tube formation  (ISO)
enteric nervous system development  (ISO)
GDF15-GFRAL signaling pathway  (ISO)
glial cell-derived neurotrophic factor receptor signaling pathway  (ISO,ISS)
homophilic cell adhesion via plasma membrane adhesion molecules  (IEA)
innervation  (IMP)
MAPK cascade  (ISO)
membrane protein proteolysis  (ISO)
nervous system development  (ISO)
neural crest cell migration  (ISO)
neuron cell-cell adhesion  (ISO)
neuron differentiation  (ISO)
neuron maturation  (ISO)
Peyer's patch morphogenesis  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell size  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of MAPK cascade  (ISO,ISS)
positive regulation of metanephric glomerulus development  (ISO)
positive regulation of neuron maturation  (IMP)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
regulation of axonogenesis  (ISO)
regulation of cell adhesion  (ISO)
response to pain  (ISO)
response to xenobiotic stimulus  (IEP)
retina development in camera-type eye  (IEP)
ureter maturation  (ISO)
ureteric bud development  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Up-regulation of GDNFR-alpha and c-ret mRNA in facial motor neurons following facial nerve injury in the rat. Burazin TC and Gundlach AL, Brain Res Mol Brain Res. 1998 Apr;55(2):331-6.
2. Genetic mapping of the RET protooncogene on rat chromosome 4. Canzian F, etal., Mamm Genome 1995 Jun;6(6):433-5.
3. Time-course of GDNF and its receptor expression after brain injury in the rat. Cheng Q, etal., Neurosci Lett. 2008 Jul 4;439(1):24-9. Epub 2008 May 1.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes. Incoronato M, etal., Cell Signal. 2004 Jul;16(7):847-56.
7. Expression of glial cell line-derived neurotrophic factor family members and their receptors in pancreatic cancers. Ito Y, etal., Surgery. 2005 Oct;138(4):788-94.
8. Hirschsprung disease is linked to defects in neural crest stem cell function. Iwashita T, etal., Science 2003 Aug 15;301(5635):972-6.
9. Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth. Jiao L, etal., Cell Res. 2011 Feb;21(2):327-37. doi: 10.1038/cr.2010.139. Epub 2010 Sep 28.
10. Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats. Kitagawa H, etal., Brain Res. 1999 Jul 10;834(1-2):190-5.
11. Regulation of GDNF and its receptor components GFR-alpha1, -alpha2 and Ret during development and in the mature retino-collicular pathway. Kretz A, etal., Brain Res. 2006 May 23;1090(1):1-14. Epub 2006 May 2.
12. Regulation of c-Ret, GFRalpha1, and GFRalpha2 in the substantia nigra pars compacta in a rat model of Parkinson's disease. Marco S, etal., J Neurobiol. 2002 Sep 15;52(4):343-51.
13. cDNA sequence and genomic structure of the rat RET proto-oncogene. Matera I, etal., DNA Seq 2000;11(5):405-17.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation. Pierchala BA, etal., J Neurosci. 2006 Mar 8;26(10):2777-87.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Adrenergic differentiation and Ret expression in rat pheochromocytomas. Powers JF, etal., Endocr Pathol. 2008 Spring;19(1):9-16.
20. Up-regulation of ret by reserpine in the adult rat adrenal medulla. Powers JF, etal., Neuroscience. 2005;132(3):605-12.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. The long and short isoforms of Ret function as independent signaling complexes. Tsui-Pierchala BA, etal., J Biol Chem 2002 Sep 13;277(37):34618-25. Epub 2002 Jun 28.
26. Discordant expression of c-Ret and glial cell line-derived neurotrophic factor receptor alpha-1 mRNAs in response to motor nerve injury in neonate rats. Tsujino H, etal., Brain Res Mol Brain Res. 1999 Jul 5;70(2):298-303.
27. RET variants and haplotype analysis in a cohort of Czech patients with Hirschsprung disease. Vaclavikova E, etal., PLoS One. 2014 Jun 4;9(6):e98957. doi: 10.1371/journal.pone.0098957. eCollection 2014.
28. Upregulation of glial cell line-derived neurotrophic factor and artemin mRNA in the auditory nerve of deafened rats. Wissel K, etal., Neuroreport. 2006 Jun 26;17(9):875-8.
29. The relationship between overexpression of glial cell-derived neurotrophic factor and its RET receptor with progression and prognosis of human pancreatic cancer. Zeng Q, etal., J Int Med Res. 2008 Jul-Aug;36(4):656-64.
30. A common RET variant is associated with reduced newborn kidney size and function. Zhang Z, etal., J Am Soc Nephrol. 2008 Oct;19(10):2027-34. doi: 10.1681/ASN.2007101098.
31. Diagnosis and surgical treatment of multiple endocrine neoplasia. Zhou GW, etal., Chin Med J (Engl). 2009 Jul 5;122(13):1495-500.
Additional References at PubMed
PMID:9576965   PMID:9834195   PMID:10545102   PMID:10921886   PMID:11069590   PMID:11445581   PMID:12195422   PMID:12527893   PMID:14555660   PMID:15233745   PMID:15242795   PMID:15302866  
PMID:15569713   PMID:16569669   PMID:16672314   PMID:16773224   PMID:16818623   PMID:17047028   PMID:17183535   PMID:17322904   PMID:17380130   PMID:17538205   PMID:17553423   PMID:17910947  
PMID:18668157   PMID:18753381   PMID:18845535   PMID:19133164   PMID:19366855   PMID:19551609   PMID:19823924   PMID:20237269   PMID:20392937   PMID:20533997   PMID:20682772   PMID:20702524  
PMID:21134561   PMID:21357690   PMID:21521737   PMID:22128160   PMID:22897442   PMID:23382219   PMID:23413818   PMID:23872421   PMID:27226544   PMID:27994058   PMID:28846097   PMID:28846099  
PMID:28953886   PMID:29018141   PMID:30541958   PMID:34273501   PMID:37178997  


Genomics

Comparative Map Data
Ret
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84152,998,344 - 153,040,556 (-)NCBIGRCr8
mRatBN7.24151,325,969 - 151,368,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4151,326,431 - 151,368,176 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4157,589,266 - 157,631,480 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04153,373,235 - 153,415,450 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04151,996,254 - 152,038,470 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04150,202,170 - 150,249,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,202,058 - 150,244,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04216,130,142 - 216,177,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,448,179 - 154,491,103 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14154,693,019 - 154,735,944 (-)NCBI
Celera4140,198,457 - 140,240,663 (-)NCBICelera
Cytogenetic Map4q42NCBI
RET
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381043,077,069 - 43,130,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1043,077,064 - 43,130,351 (+)EnsemblGRCh38hg38GRCh38
GRCh371043,572,517 - 43,625,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361042,892,523 - 42,945,805 (+)NCBINCBI36Build 36hg18NCBI36
Build 341042,892,532 - 42,944,955NCBI
Celera1039,575,663 - 39,628,954 (+)NCBICelera
Cytogenetic Map10q11.21NCBI
HuRef1040,098,756 - 40,151,896 (+)NCBIHuRef
CHM1_11043,611,715 - 43,665,000 (+)NCBICHM1_1
T2T-CHM13v2.01043,954,542 - 44,007,848 (+)NCBIT2T-CHM13v2.0
Ret
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396118,128,709 - 118,174,705 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6118,128,706 - 118,174,679 (-)EnsemblGRCm39 Ensembl
GRCm386118,151,748 - 118,197,744 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6118,151,745 - 118,197,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv376118,101,766 - 118,147,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366118,119,472 - 118,162,752 (-)NCBIMGSCv36mm8
Celera6119,974,414 - 120,020,450 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map655.86NCBI
Ret
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555461,221,995 - 1,253,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555461,221,995 - 1,252,147 (+)NCBIChiLan1.0ChiLan1.0
RET
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2855,790,324 - 55,866,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11055,795,492 - 55,848,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01040,050,396 - 40,103,629 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11043,256,437 - 43,286,340 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1043,249,468 - 43,284,331 (+)Ensemblpanpan1.1panPan2
RET
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1283,946,132 - 3,995,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl283,947,232 - 3,994,210 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha284,180,472 - 4,211,554 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,124,929 - 4,176,146 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,126,037 - 4,174,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1283,922,935 - 3,954,018 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,965,997 - 3,997,076 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,100,288 - 4,131,400 (-)NCBIUU_Cfam_GSD_1.0
Ret
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721383,803,446 - 83,856,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366172,927,155 - 2,980,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366172,927,185 - 2,980,594 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RET
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1461,305,841 - 61,361,412 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11461,305,818 - 61,361,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21466,136,477 - 66,192,220 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RET
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1938,746,088 - 38,798,773 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl938,769,170 - 38,796,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605647,691,006 - 47,743,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ret
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624922382,399 - 413,281 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624922382,462 - 413,227 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ret
297 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:445
Count of miRNA genes:245
Interacting mature miRNAs:296
Transcripts:ENSRNOT00000047685
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat

Markers in Region
AA859878  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24151,328,880 - 151,329,062 (+)MAPPERmRatBN7.2
Rnor_6.04150,205,086 - 150,205,267NCBIRnor6.0
Rnor_5.04216,133,054 - 216,133,235UniSTSRnor5.0
RGSC_v3.44154,451,091 - 154,451,272UniSTSRGSC3.4
Celera4140,201,369 - 140,201,550UniSTS
RH 3.4 Map4969.31UniSTS
Cytogenetic Map4q42UniSTS
Ret  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24151,329,531 - 151,329,638 (+)MAPPERmRatBN7.2
Rnor_6.04150,205,737 - 150,205,843NCBIRnor6.0
Rnor_5.04216,133,705 - 216,133,811UniSTSRnor5.0
RGSC_v3.44154,451,742 - 154,451,848UniSTSRGSC3.4
Celera4140,202,020 - 140,202,126UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 18 14 12 4
Low 3 29 16 4 19 4 8 11 52 2 26 7 8
Below cutoff 14 35 31 31 4 17 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001110099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH006777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ298999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ299017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000047685   ⟹   ENSRNOP00000047793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4151,326,431 - 151,368,176 (-)Ensembl
Rnor_6.0 Ensembl4150,202,058 - 150,244,372 (-)Ensembl
RefSeq Acc Id: NM_001110099   ⟹   NP_001103569
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84153,001,167 - 153,040,556 (-)NCBI
mRatBN7.24151,328,786 - 151,368,176 (-)NCBI
Rnor_6.04150,204,991 - 150,244,380 (-)NCBI
Rnor_5.04216,130,142 - 216,177,139 (-)NCBI
RGSC_v3.44154,448,179 - 154,491,103 (-)RGD
Celera4140,201,274 - 140,240,663 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012643   ⟹   NP_036775
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84152,998,350 - 153,040,556 (-)NCBI
mRatBN7.24151,325,969 - 151,368,176 (-)NCBI
Rnor_6.04150,202,174 - 150,244,380 (-)NCBI
Rnor_5.04216,130,142 - 216,177,139 (-)NCBI
RGSC_v3.44154,448,179 - 154,491,103 (-)RGD
Celera4140,198,457 - 140,240,663 (-)RGD
Sequence:
RefSeq Acc Id: XM_063285561   ⟹   XP_063141631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84152,998,344 - 153,032,403 (-)NCBI
RefSeq Acc Id: NP_036775   ⟸   NM_012643
- Peptide Label: isoform a precursor
- UniProtKB: Q9EPA1 (UniProtKB/Swiss-Prot),   Q9EPC3 (UniProtKB/Swiss-Prot),   G3V9H8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001103569   ⟸   NM_001110099
- Peptide Label: isoform b precursor
- UniProtKB: A6IL58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000047793   ⟸   ENSRNOT00000047685
RefSeq Acc Id: XP_063141631   ⟸   XM_063285561
- Peptide Label: isoform X1
Protein Domains
Cadherin   Protein kinase   Ret cadherin like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9H8-F1-model_v2 AlphaFold G3V9H8 1-1115 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3556 AgrOrtholog
BioCyc Gene G2FUF-43236 BioCyc
Ensembl Genes ENSRNOG00000014751 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047685 ENTREZGENE
  ENSRNOT00000047685.5 UniProtKB/Swiss-Prot
Gene3D-CATH Cadherins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cadherin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ret_CLD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ret_CLD3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RET_CLD4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_Ret_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24716 UniProtKB/Swiss-Prot
NCBI Gene 24716 ENTREZGENE
PANTHER PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  RET_CLD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RET_CLD3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RET_CLD4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ret PhenoGen
PIRSF TyrPK_receptor_Ret UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CADHERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014751 RatGTEx
SMART TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Cadherin-like UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL
  SSF49313 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A6IL58 ENTREZGENE, UniProtKB/TrEMBL
  G3V9H8 ENTREZGENE
  Q63197_RAT UniProtKB/TrEMBL
  Q9EPA1 ENTREZGENE
  Q9EPC3 ENTREZGENE
  RET_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9EPA1 UniProtKB/Swiss-Prot
  Q9EPC3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Ret  ret proto-oncogene    Ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease)  Name updated 629478 APPROVED
2002-06-10 Ret  Ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function receptor for glial cell line-derived neurotrophic factor family ligands 1304247
gene_product member of the receptor tyrosine kinase family 633884