Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ret (ret proto-oncogene) Rattus norvegicus
Symbol: Ret
Name: ret proto-oncogene
Description: Predicted to have calcium ion binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in nervous system development; response to drug; and retina development in camera-type eye. Localizes to several cellular components, including the early endosome; membrane raft; and neuron projection. Biomarker of brain ischemia and pheochromocytoma. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; congenital central hypoventilation syndrome; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; and multiple endocrine neoplasia type 2B. Orthologous to human RET (ret proto-oncogene); PARTICIPATES IN endocytosis pathway; thyroid cancer pathway; INTERACTS WITH (+)-pilocarpine; (-)-anisomycin; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE.
Type: protein-coding
Also known as: proto-oncogene tyrosine-protein kinase receptor Ret; receptor tyrosine kinase; Ret gene for receptor tyrosin; Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease); Ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease)
Homo sapiens (human) : RET (ret proto-oncogene)  HGNC  Alliance
Mus musculus (house mouse) : Ret (ret proto-oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ret (ret proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : RET (ret proto-oncogene)
Canis lupus familiaris (dog) : RET (ret proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ret (ret proto-oncogene)
Sus scrofa (pig) : RET (ret proto-oncogene)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04150,202,170 - 150,249,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04216,130,142 - 216,177,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,448,179 - 154,491,103 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14154,693,019 - 154,735,944 (-)NCBI
Celera4140,198,457 - 140,240,663 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links