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Gene: Ret (ret proto-oncogene) Rattus norvegicus
Symbol: Ret
Name: ret proto-oncogene
Description: Predicted to have calcium ion binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in nervous system development; response to drug; and retina development in camera-type eye. Localizes to several cellular components, including early endosome; membrane raft; and neuronal cell body. Biomarker of brain ischemia and pheochromocytoma. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; congenital central hypoventilation syndrome; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; and multiple endocrine neoplasia type 2B. Orthologous to human RET (ret proto-oncogene); PARTICIPATES IN endocytosis pathway; thyroid cancer pathway; INTERACTS WITH (+)-pilocarpine; (-)-anisomycin; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: proto-oncogene tyrosine-protein kinase receptor Ret; receptor tyrosine kinase; Ret gene for receptor tyrosin; Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease); Ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease)
Homo sapiens (human) : RET (ret proto-oncogene)  HGNC  Alliance
Mus musculus (house mouse) : Ret (ret proto-oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ret (ret proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : RET (ret proto-oncogene)
Canis lupus familiaris (dog) : RET (ret proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ret (ret proto-oncogene)
Sus scrofa (pig) : RET (ret proto-oncogene)
Chlorocebus sabaeus (African green monkey) : RET (ret proto-oncogene)
Heterocephalus glaber (naked mole-rat) : Ret (ret proto-oncogene)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04150,202,170 - 150,249,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,202,058 - 150,244,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04216,130,142 - 216,177,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,448,179 - 154,491,103 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14154,693,019 - 154,735,944 (-)NCBI
Celera4140,198,457 - 140,240,663 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ret
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3556
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.