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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3556
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ret
Name: ret proto-oncogene
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Retincreases expressionISORET (Homo sapiens)6480464CTDEstradiol results in increased expression of RET mRNAPMID:24758408 PMID:26865669 PMID:28711546 PMID:31614463
Retmultiple interactionsISORET (Homo sapiens)6480464CTD[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of RET mRNA; [Estradiol co-treated with EGF protein] results in increased expression of RET mRNA; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of RET mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of RET mRNA]PMID:20823114 PMID:24758408
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