Ret (ret proto-oncogene) - Rat Genome Database

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Gene: Ret (ret proto-oncogene) Mus musculus
Analyze
Symbol: Ret
Name: ret proto-oncogene
RGD ID: 11234
MGI Page MGI
Description: Enables transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including Peyer's patch morphogenesis; neuron cell-cell adhesion; and positive regulation of metanephric glomerulus development. Acts upstream of or within several processes, including nervous system development; positive regulation of cell size; and positive regulation of macromolecule metabolic process. Predicted to be located in dendrite; endosome; and neuronal cell body. Predicted to be part of plasma membrane protein complex and receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including branchial arch; genitourinary system; gut; nervous system; and sensory organ. Used to study Hirschsprung's disease; clubfoot; multiple endocrine neoplasia type 2B; and pheochromocytoma. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (ret proto-oncogene).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-Re; c-Ret; proto-oncogene c-Ret; proto-oncogene tyrosine-protein kinase receptor Ret; PTC; RET5; RET51; RET9
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396118,128,709 - 118,174,705 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6118,128,706 - 118,174,679 (-)EnsemblGRCm39 Ensembl
GRCm386118,151,748 - 118,197,744 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6118,151,745 - 118,197,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv376118,101,766 - 118,147,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366118,119,472 - 118,162,752 (-)NCBIMGSCv36mm8
Celera6119,974,414 - 120,020,450 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map655.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
appendicitis  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Burkitt lymphoma  (ISO)
CAKUT  (ISO)
clubfoot  (IAGP)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital central hypoventilation syndrome  (ISO)
Constipation  (ISO)
Deafness  (ISO)
diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  (ISO)
disease of cellular proliferation  (ISO)
Dwarfism  (ISO)
extraosseous Ewing sarcoma  (ISO)
Facial Nerve Injuries  (ISO)
Familial Amyloidosis  (ISO)
familial medullary thyroid carcinoma  (ISO)
genetic disease  (ISO)
gingival overgrowth  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hirschsprung Disease 1  (ISO)
Hirschsprung's disease  (IAGP,ISO)
Hypertelorism  (ISO)
Hypoglossal Nerve Injuries  (ISO)
hypothyroidism  (ISO)
Islet Cell Tumor Syndrome  (ISO)
Joint Instability  (ISO)
Lymphatic Metastasis  (ISO)
Medullary Carcinomas  (ISO)
medullary thyroid carcinoma  (ISO)
medulloblastoma  (ISO)
megacolon  (ISO)
microcephaly  (ISO)
multiple endocrine neoplasia  (ISO)
multiple endocrine neoplasia type 1  (ISO)
multiple endocrine neoplasia type 2A  (ISO)
multiple endocrine neoplasia type 2B  (IAGP,ISO)
multiple endocrine neoplasia type 4  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
papillary thyroid carcinoma  (ISO)
Parkinsonism  (ISO)
pheochromocytoma  (IAGP,ISO)
pilocytic astrocytoma  (ISO)
renal agenesis  (ISO)
Renal Hypodysplasia/Aplasia 1  (ISO)
renal hypoplasia  (ISO)
status epilepticus  (ISO)
tetralogy of Fallot  (ISO)
thyroid gland carcinoma  (ISO)
Thyroid Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-anisomycin  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bucladesine  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clomiphene  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
D-glucose  (ISO)
dabigatran  (ISO)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dichromium trioxide  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
endrin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
estrone  (ISO)
ethanol  (EXP,ISO)
fonofos  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (EXP)
graphite  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irbesartan  (ISO)
ivermectin  (ISO)
L-cysteine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
manganese(II) chloride  (ISO)
Meclizine  (ISO)
medroxyprogesterone acetate  (ISO)
megestrol  (ISO)
mercury dibromide  (ISO)
mestranol  (ISO)
methapyrilene  (ISO)
Methazolamide  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
mifepristone  (ISO)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
oxaliplatin  (ISO)
oxidopamine  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
picene  (ISO)
pinostrobin  (ISO)
ponatinib  (ISO)
propanal  (ISO)
Ptaquiloside  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
sorafenib  (ISO)
staurosporine  (ISO)
sulindac  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vandetanib  (ISO)
verapamil  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (TAS)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA,IGI)
cellular response to retinoic acid  (IEA,ISO)
chromatin remodeling  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
embryonic epithelial tube formation  (IGI)
enteric nervous system development  (IMP)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA)
GDF15-GFRAL signaling pathway  (IEA,ISO)
glial cell-derived neurotrophic factor receptor signaling pathway  (ISO,ISS)
hepatocyte growth factor receptor signaling pathway  (IEA)
homophilic cell adhesion via plasma membrane adhesion molecules  (IEA)
innervation  (IEA,ISO)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
macrophage colony-stimulating factor signaling pathway  (IEA)
MAPK cascade  (IGI)
membrane protein proteolysis  (IEA,ISO)
nervous system development  (IMP)
neural crest cell migration  (IMP)
neuron cell-cell adhesion  (IDA,ISO)
neuron differentiation  (IMP)
neuron maturation  (IMP)
Peyer's patch morphogenesis  (IMP)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of cell adhesion mediated by integrin  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell size  (IMP)
positive regulation of cysteine-type endopeptidase activity  (ISO)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of MAPK cascade  (ISO,ISS)
positive regulation of metanephric glomerulus development  (IMP)
positive regulation of neuron maturation  (IEA,ISO)
positive regulation of neuron projection development  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
regulation of axonogenesis  (IMP)
regulation of cell adhesion  (ISO)
response to pain  (IMP)
response to xenobiotic stimulus  (IEA,ISO)
retina development in camera-type eye  (IEA,ISO)
ureter maturation  (IMP)
ureteric bud development  (IMP)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

Cellular Component
axon  (IBA,IEA,ISO)
dendrite  (IEA,ISO)
early endosome  (IEA,ISO)
endosome membrane  (IEA,ISO)
neuronal cell body  (IEA,ISO)
plasma membrane  (IBA,ISO,ISS,TAS)
plasma membrane protein complex  (IEA,ISO)
receptor complex  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal gland morphology  (IAGP)
abnormal adrenal medulla morphology  (IAGP)
abnormal axon guidance  (IAGP)
abnormal branching involved in ureteric bud morphogenesis  (IAGP)
abnormal cardiac ganglion morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal defecation  (IAGP)
abnormal embryo development  (IAGP)
abnormal enteric ganglia morphology  (IAGP)
abnormal enteric nervous system morphology  (IAGP)
abnormal enteric neural crest cell migration  (IAGP)
abnormal enteric neural crest cell morphology  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal facial motor nucleus morphology  (IAGP)
abnormal feces composition  (IAGP)
abnormal gastrocnemius morphology  (IAGP)
abnormal hypaxial muscle morphology  (IAGP)
abnormal hypoglossal nucleus morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal innervation pattern to muscle  (IAGP)
abnormal intestinal peristalsis  (IAGP)
abnormal jejunum morphology  (IAGP)
abnormal kidney collecting duct morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney medulla development  (IAGP)
abnormal kidney mesenchyme morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal large intestine morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal mesonephros morphology  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal motor neuron innervation pattern  (IAGP)
abnormal muscle spindle morphology  (IAGP)
abnormal neurite morphology  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neurotransmitter secretion  (IAGP)
abnormal parasympathetic postganglionic fiber morphology  (IAGP)
abnormal prevertebral ganglion morphology  (IAGP)
abnormal pterygopalatine ganglion morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal stellate ganglion morphology  (IAGP)
abnormal submandibular gland morphology  (IAGP)
abnormal sympathetic ganglion morphology  (IAGP)
abnormal sympathetic neuron morphology  (IAGP)
abnormal sympathetic postganglionic fiber morphology  (IAGP)
abnormal synaptic dopamine release  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal ureter development  (IAGP)
abnormal ureter morphology  (IAGP)
abnormal ureteric bud elongation  (IAGP)
abnormal ureteric bud invasion  (IAGP)
abnormal ureteric bud morphology  (IAGP)
abnormal urinary bladder morphology  (IAGP)
abnormal vas deferens morphology  (IAGP)
absent enteric neural crest cell  (IAGP)
absent enteric neurons  (IAGP)
absent kidney  (IAGP)
absent kidney cortex  (IAGP)
absent kidney medulla  (IAGP)
absent nephrogenic zone  (IAGP)
absent superior cervical ganglion  (IAGP)
absent ureter  (IAGP)
adrenal cortical hyperplasia  (IAGP)
adrenergic chromaffin cell hyperplasia  (IAGP)
aganglionic megacolon  (IAGP)
arrest of spermatogenesis  (IAGP)
blind ureter  (IAGP)
clubfoot  (IAGP)
cryptorchism  (IAGP)
decreased body weight  (IAGP)
decreased feces water content  (IAGP)
decreased kidney weight  (IAGP)
decreased locomotor activity  (IAGP)
decreased motor neuron number  (IAGP)
decreased neural crest cell number  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased renal glomerulus number  (IAGP)
dilated renal glomerular capsule  (IAGP)
dilated renal tubule  (IAGP)
dilated ureter  (IAGP)
distended abdomen  (IAGP)
distended ileum  (IAGP)
ectopic kidney  (IAGP)
ectopic ovary  (IAGP)
ectopic testis  (IAGP)
ectopic ureteric bud  (IAGP)
enlarged ileum  (IAGP)
glomerulosclerosis  (IAGP)
hydronephrosis  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
increased cell proliferation  (IAGP)
increased ganglioneuroma incidence  (IAGP)
increased kidney apoptosis  (IAGP)
increased metanephric mesenchyme apoptosis  (IAGP)
increased neuroblastoma incidence  (IAGP)
increased neuron apoptosis  (IAGP)
increased pheochromocytoma incidence  (IAGP)
increased thyroid adenoma incidence  (IAGP)
intestinal hypoperistalsis  (IAGP)
kidney atrophy  (IAGP)
kidney cyst  (IAGP)
large ureter  (IAGP)
loss of dopaminergic neurons  (IAGP)
male infertility  (IAGP)
muscular atrophy  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
oligohydramnios  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
renal cast  (IAGP)
renal hypoplasia  (IAGP)
seminiferous tubule degeneration  (IAGP)
single kidney  (IAGP)
small dorsal root ganglion  (IAGP)
small kidney  (IAGP)
small superior cervical ganglion  (IAGP)
thyroid gland hyperplasia  (IAGP)
ureter obstruction  (IAGP)
ureter stenosis  (IAGP)
weakness  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Up-regulation of GDNFR-alpha and c-ret mRNA in facial motor neurons following facial nerve injury in the rat. Burazin TC and Gundlach AL, Brain Res Mol Brain Res. 1998 Apr;55(2):331-6.
2. Genetic mapping of the RET protooncogene on rat chromosome 4. Canzian F, etal., Mamm Genome 1995 Jun;6(6):433-5.
3. Time-course of GDNF and its receptor expression after brain injury in the rat. Cheng Q, etal., Neurosci Lett. 2008 Jul 4;439(1):24-9. Epub 2008 May 1.
4. Expression of glial cell line-derived neurotrophic factor family members and their receptors in pancreatic cancers. Ito Y, etal., Surgery. 2005 Oct;138(4):788-94.
5. Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats. Kitagawa H, etal., Brain Res. 1999 Jul 10;834(1-2):190-5.
6. Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization. Ludwig T, etal., J Biol Chem 1992 Jun 15;267(17):12211-9.
7. Regulation of c-Ret, GFRalpha1, and GFRalpha2 in the substantia nigra pars compacta in a rat model of Parkinson's disease. Marco S, etal., J Neurobiol. 2002 Sep 15;52(4):343-51.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Mouse chromosomal location of three epithelial sodium channel subunit genes and an apical sodium chloride cotransporter gene. Pathak BG, etal., Genomics 1996 Apr 1;33(1):124-7.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Adrenergic differentiation and Ret expression in rat pheochromocytomas. Powers JF, etal., Endocr Pathol. 2008 Spring;19(1):9-16.
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Discordant expression of c-Ret and glial cell line-derived neurotrophic factor receptor alpha-1 mRNAs in response to motor nerve injury in neonate rats. Tsujino H, etal., Brain Res Mol Brain Res. 1999 Jul 5;70(2):298-303.
19. RET variants and haplotype analysis in a cohort of Czech patients with Hirschsprung disease. Vaclavikova E, etal., PLoS One. 2014 Jun 4;9(6):e98957. doi: 10.1371/journal.pone.0098957. eCollection 2014.
20. Upregulation of glial cell line-derived neurotrophic factor and artemin mRNA in the auditory nerve of deafened rats. Wissel K, etal., Neuroreport. 2006 Jun 26;17(9):875-8.
21. The relationship between overexpression of glial cell-derived neurotrophic factor and its RET receptor with progression and prognosis of human pancreatic cancer. Zeng Q, etal., J Int Med Res. 2008 Jul-Aug;36(4):656-64.
22. A common RET variant is associated with reduced newborn kidney size and function. Zhang Z, etal., J Am Soc Nephrol. 2008 Oct;19(10):2027-34. doi: 10.1681/ASN.2007101098.
23. Diagnosis and surgical treatment of multiple endocrine neoplasia. Zhou GW, etal., Chin Med J (Engl). 2009 Jul 5;122(13):1495-500.
Additional References at PubMed
PMID:1374037   PMID:1765007   PMID:3078962   PMID:7543410   PMID:7588749   PMID:7590254   PMID:7595168   PMID:7629107   PMID:7906865   PMID:7990960   PMID:8114940   PMID:8118873  
PMID:8183561   PMID:8221886   PMID:8290261   PMID:8306871   PMID:8455936   PMID:8530057   PMID:8536638   PMID:8565843   PMID:8565847   PMID:8575306   PMID:8666231   PMID:8674430  
PMID:8787761   PMID:8812145   PMID:8812432   PMID:8845150   PMID:8889551   PMID:8934550   PMID:8967950   PMID:9027502   PMID:9092472   PMID:9115735   PMID:9165114   PMID:9182803  
PMID:9262196   PMID:9334423   PMID:9342439   PMID:9353119   PMID:9354331   PMID:9374404   PMID:9405660   PMID:9415430   PMID:9435281   PMID:9448325   PMID:9452475   PMID:9454853  
PMID:9539123   PMID:9576965   PMID:9585504   PMID:9637684   PMID:9637690   PMID:9704933   PMID:9731539   PMID:9749804   PMID:9758704   PMID:9767163   PMID:9786421   PMID:9790773  
PMID:9834195   PMID:9895385   PMID:9935163   PMID:10021334   PMID:10067959   PMID:10068631   PMID:10069332   PMID:10076570   PMID:10090080   PMID:10101119   PMID:10231194   PMID:10331972  
PMID:10331988   PMID:10349636   PMID:10357931   PMID:10360575   PMID:10373304   PMID:10380889   PMID:10393426   PMID:10415156   PMID:10482239   PMID:10536054   PMID:10564089   PMID:10570734  
PMID:10572052   PMID:10579975   PMID:10595945   PMID:10644000   PMID:10668924   PMID:10675330   PMID:10704385   PMID:10712625   PMID:10749566   PMID:10844592   PMID:10860579   PMID:10864957  
PMID:10864958   PMID:10972938   PMID:10974669   PMID:10995764   PMID:11003834   PMID:11016655   PMID:11042159   PMID:11044402   PMID:11069590   PMID:11076752   PMID:11076861   PMID:11085274  
PMID:11114734   PMID:11133159   PMID:11138002   PMID:11160437   PMID:11180950   PMID:11217851   PMID:11423973   PMID:11445581   PMID:11470823   PMID:11493536   PMID:11494127   PMID:11498051  
PMID:11562352   PMID:11564179   PMID:11581159   PMID:11585664   PMID:11641220   PMID:11688560   PMID:11709725   PMID:11731455   PMID:11749040   PMID:11774071   PMID:12063395   PMID:12087092  
PMID:12126922   PMID:12139916   PMID:12195422   PMID:12355085   PMID:12361965   PMID:12372284   PMID:12399307   PMID:12417529   PMID:12435636   PMID:12466851   PMID:12477932   PMID:12482961  
PMID:12508309   PMID:12574515   PMID:12591246   PMID:12591599   PMID:12668632   PMID:12702665   PMID:12729564   PMID:12759189   PMID:12783789   PMID:12810600   PMID:12831858   PMID:12884298  
PMID:12917363   PMID:12948444   PMID:14522971   PMID:14534138   PMID:14607833   PMID:14656760   PMID:14659090   PMID:14973278   PMID:14985435   PMID:15196959   PMID:15201220   PMID:15201225  
PMID:15204970   PMID:15233745   PMID:15242795   PMID:15326486   PMID:15326489   PMID:15328070   PMID:15329349   PMID:15337776   PMID:15340065   PMID:15342483   PMID:15351743   PMID:15381279  
PMID:15469971   PMID:15489334   PMID:15517993   PMID:15541311   PMID:15561438   PMID:15569713   PMID:15584907   PMID:15589513   PMID:15618518   PMID:15621530   PMID:15632018   PMID:15634693  
PMID:15691764   PMID:15703280   PMID:15748846   PMID:15768390   PMID:15855632   PMID:15869472   PMID:15872002   PMID:15893302   PMID:15905075   PMID:15930111   PMID:15976074   PMID:15979200  
PMID:16018995   PMID:16054034   PMID:16133146   PMID:16138831   PMID:16141072   PMID:16141073   PMID:16144862   PMID:16176945   PMID:16216236   PMID:16223478   PMID:16227613   PMID:16237148  
PMID:16307583   PMID:16319112   PMID:16319116   PMID:16319924   PMID:16442091   PMID:16446141   PMID:16446142   PMID:16452504   PMID:16484222   PMID:16497798   PMID:16511601   PMID:16545622  
PMID:16551639   PMID:16565500   PMID:16600854   PMID:16602821   PMID:16632597   PMID:16677628   PMID:16849523   PMID:16952347   PMID:17036046   PMID:17047028   PMID:17050626   PMID:17065462  
PMID:17119020   PMID:17131407   PMID:17172448   PMID:17298183   PMID:17310246   PMID:17314325   PMID:17322904   PMID:17362911   PMID:17372903   PMID:17396120   PMID:17475787   PMID:17478475  
PMID:17507395   PMID:17531968   PMID:17537792   PMID:17553423   PMID:17761947   PMID:17882221   PMID:17951031   PMID:18006159   PMID:18056810   PMID:18094025   PMID:18171921   PMID:18177851  
PMID:18189271   PMID:18216204   PMID:18233958   PMID:18248620   PMID:18276829   PMID:18287559   PMID:18305247   PMID:18316595   PMID:18316596   PMID:18358465   PMID:18363967   PMID:18385258  
PMID:18395091   PMID:18414682   PMID:18417692   PMID:18430798   PMID:18497757   PMID:18498732   PMID:18498735   PMID:18542059   PMID:18551627   PMID:18561907   PMID:18565740   PMID:18570257  
PMID:18583418   PMID:18670373   PMID:18676765   PMID:18684739   PMID:18753381   PMID:18787044   PMID:18839409   PMID:18845535   PMID:19010920   PMID:19053769   PMID:19056869   PMID:19112489  
PMID:19150651   PMID:19247964   PMID:19273906   PMID:19321127   PMID:19369650   PMID:19509066   PMID:19551609   PMID:19580811   PMID:19686681   PMID:19710321   PMID:19715689   PMID:19729440  
PMID:19741018   PMID:19755105   PMID:19767128   PMID:19780901   PMID:19805360   PMID:19809516   PMID:19829382   PMID:19898483   PMID:19961928   PMID:20007774   PMID:20040494   PMID:20040500  
PMID:20063415   PMID:20064391   PMID:20064392   PMID:20084103   PMID:20096094   PMID:20110328   PMID:20139349   PMID:20142273   PMID:20160347   PMID:20213756   PMID:20237269   PMID:20303521  
PMID:20386724   PMID:20392937   PMID:20392943   PMID:20422010   PMID:20454682   PMID:20463033   PMID:20514292   PMID:20534675   PMID:20616001   PMID:20616061   PMID:20682772   PMID:20696247  
PMID:20816800   PMID:20840354   PMID:20843830   PMID:20844136   PMID:20855470   PMID:20939858   PMID:20943750   PMID:20944551   PMID:20977903   PMID:21035938   PMID:21060807   PMID:21068058  
PMID:21070764   PMID:21109439   PMID:21117150   PMID:21118713   PMID:21128305   PMID:21134556   PMID:21151121   PMID:21212101   PMID:21239429   PMID:21281623   PMID:21283077   PMID:21289216  
PMID:21300867   PMID:21303848   PMID:21339645   PMID:21343368   PMID:21350013   PMID:21357690   PMID:21395865   PMID:21420949   PMID:21521737   PMID:21523854   PMID:21530183   PMID:21533152  
PMID:21543603   PMID:21552539   PMID:21612845   PMID:21613322   PMID:21699792   PMID:21731775   PMID:21734270   PMID:21813676   PMID:21831920   PMID:21858105   PMID:21873635   PMID:21900559  
PMID:21903675   PMID:21949185   PMID:21949878   PMID:21963425   PMID:22015719   PMID:22103411   PMID:22110055   PMID:22114682   PMID:22128334   PMID:22215810   PMID:22215812   PMID:22228097  
PMID:22232066   PMID:22234463   PMID:22253804   PMID:22282599   PMID:22304922   PMID:22326227   PMID:22345400   PMID:22360967   PMID:22410172   PMID:22421622   PMID:22493062   PMID:22511595  
PMID:22514301   PMID:22586713   PMID:22627285   PMID:22718343   PMID:22723712   PMID:22732841   PMID:22748019   PMID:22753894   PMID:22771245   PMID:22787056   PMID:22828515   PMID:22841315  
PMID:22855506   PMID:22897442   PMID:22902718   PMID:22912798   PMID:22922260   PMID:22998873   PMID:23064016   PMID:23136392   PMID:23201013   PMID:23262364   PMID:23283078   PMID:23300832  
PMID:23333276   PMID:23382219   PMID:23409123   PMID:23413832   PMID:23473982   PMID:23478408   PMID:23516305   PMID:23537899   PMID:23554478   PMID:23555292   PMID:23555309   PMID:23591430  
PMID:23616926   PMID:23641053   PMID:23648511   PMID:23701859   PMID:23704941   PMID:23762375   PMID:23804090   PMID:23828865   PMID:23872421   PMID:23903190   PMID:23918385   PMID:23993789  
PMID:23994200   PMID:24027274   PMID:24107967   PMID:24143282   PMID:24198358   PMID:24198362   PMID:24216510   PMID:24262984   PMID:24360544   PMID:24370450   PMID:24425877   PMID:24440154  
PMID:24516396   PMID:24550112   PMID:24603431   PMID:24637293   PMID:24637732   PMID:24699546   PMID:24700820   PMID:24721948   PMID:24752460   PMID:24780737   PMID:24811380   PMID:24850856  
PMID:24852369   PMID:24891614   PMID:24925909   PMID:24952961   PMID:25031030   PMID:25079320   PMID:25082826   PMID:25139858   PMID:25165119   PMID:25168352   PMID:25369838   PMID:25412793  
PMID:25417164   PMID:25525881   PMID:25549043   PMID:25587123   PMID:25587709   PMID:25617721   PMID:25635057   PMID:25661788   PMID:25678108   PMID:25758227   PMID:25803581   PMID:25822020  
PMID:25838128   PMID:25839327   PMID:25885041   PMID:25903664   PMID:25942625   PMID:25997579   PMID:26047795   PMID:26116666   PMID:26120033   PMID:26123588   PMID:26147533   PMID:26156989  
PMID:26243870   PMID:26290232   PMID:26356988   PMID:26400951   PMID:26572137   PMID:26586201   PMID:26604140   PMID:26658318   PMID:26687362   PMID:26758845   PMID:26813041   PMID:26854930  
PMID:26857994   PMID:26894589   PMID:26904955   PMID:26929027   PMID:26988119   PMID:27076429   PMID:27076431   PMID:27119228   PMID:27226544   PMID:27334845   PMID:27344203   PMID:27370713  
PMID:27396331   PMID:27409807   PMID:27480037   PMID:27545711   PMID:27545714   PMID:27571008   PMID:27582005   PMID:27597235   PMID:27607574   PMID:27693352   PMID:27707970   PMID:27824154  
PMID:28041852   PMID:28076782   PMID:28334784   PMID:28341395   PMID:28476948   PMID:28478097   PMID:28506996   PMID:28522527   PMID:28558017   PMID:28566702   PMID:28591570   PMID:28684471  
PMID:28705898   PMID:28846099   PMID:28869974   PMID:28899900   PMID:28993400   PMID:29031500   PMID:29045838   PMID:29078343   PMID:29093530   PMID:29129523   PMID:29135976   PMID:29158444  
PMID:29192291   PMID:29218725   PMID:29240767   PMID:29282324   PMID:29321660   PMID:29326158   PMID:29445148   PMID:29459093   PMID:29483821   PMID:29569362   PMID:29638158   PMID:29666241  
PMID:29695833   PMID:29771971   PMID:29874580   PMID:29945868   PMID:30018091   PMID:30169530   PMID:30208315   PMID:30225912   PMID:30333037   PMID:30355452   PMID:30377232   PMID:30515799  
PMID:30587537   PMID:30594740   PMID:30632787   PMID:30649340   PMID:30740044   PMID:30826183   PMID:30884088   PMID:30917305   PMID:30917309   PMID:30958726   PMID:30996124   PMID:30998504  
PMID:31084574   PMID:31171666   PMID:31242448   PMID:31248728   PMID:31300484   PMID:31534216   PMID:31801063   PMID:31818953   PMID:31923460   PMID:31924792   PMID:32001436   PMID:32015493  
PMID:32017713   PMID:32141129   PMID:32275061   PMID:32325033   PMID:32464196   PMID:32554568   PMID:32562756   PMID:32566252   PMID:32715478   PMID:32753399   PMID:32808420   PMID:32826903  
PMID:32994173   PMID:33159498   PMID:33197428   PMID:33220232   PMID:33305192   PMID:33315499   PMID:33340715   PMID:33561442   PMID:33691135   PMID:33722956   PMID:33833454   PMID:33848271  
PMID:33914865   PMID:33947839   PMID:33958373   PMID:34272903   PMID:34324195   PMID:34338291   PMID:34644112   PMID:34789880   PMID:34803580   PMID:35315772   PMID:35341793   PMID:35364055  
PMID:35462405   PMID:35589396   PMID:35798698   PMID:35815410   PMID:35904071   PMID:36098804   PMID:36194647   PMID:36303068   PMID:36334588   PMID:36418415   PMID:36521661   PMID:36626229  
PMID:36758123   PMID:36763499   PMID:36876911   PMID:36960826   PMID:37028432   PMID:37106422   PMID:37185772   PMID:37227110   PMID:37585461   PMID:37607547   PMID:37869988   PMID:37995867  
PMID:38025786   PMID:38108810   PMID:38167468   PMID:38351062   PMID:38386003   PMID:38452762   PMID:38581949   PMID:38657443   PMID:38690732   PMID:38834239   PMID:38915692   PMID:38920687  
PMID:39290714  


Genomics

Comparative Map Data
Ret
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396118,128,709 - 118,174,705 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6118,128,706 - 118,174,679 (-)EnsemblGRCm39 Ensembl
GRCm386118,151,748 - 118,197,744 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6118,151,745 - 118,197,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv376118,101,766 - 118,147,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366118,119,472 - 118,162,752 (-)NCBIMGSCv36mm8
Celera6119,974,414 - 120,020,450 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map655.86NCBI
RET
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381043,077,069 - 43,130,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1043,077,064 - 43,130,351 (+)EnsemblGRCh38hg38GRCh38
GRCh371043,572,517 - 43,625,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361042,892,523 - 42,945,805 (+)NCBINCBI36Build 36hg18NCBI36
Build 341042,892,532 - 42,944,955NCBI
Celera1039,575,663 - 39,628,954 (+)NCBICelera
Cytogenetic Map10q11.21NCBI
HuRef1040,098,756 - 40,151,896 (+)NCBIHuRef
CHM1_11043,611,715 - 43,665,000 (+)NCBICHM1_1
T2T-CHM13v2.01043,954,542 - 44,007,848 (+)NCBIT2T-CHM13v2.0
Ret
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84152,998,344 - 153,040,556 (-)NCBIGRCr8
mRatBN7.24151,325,969 - 151,368,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4151,326,431 - 151,368,176 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4157,589,266 - 157,631,480 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04153,373,235 - 153,415,450 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04151,996,254 - 152,038,470 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04150,202,170 - 150,249,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,202,058 - 150,244,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04216,130,142 - 216,177,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,448,179 - 154,491,103 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14154,693,019 - 154,735,944 (-)NCBI
Celera4140,198,457 - 140,240,663 (-)NCBICelera
Cytogenetic Map4q42NCBI
Ret
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555461,221,995 - 1,253,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555461,221,995 - 1,252,147 (+)NCBIChiLan1.0ChiLan1.0
RET
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2855,790,324 - 55,866,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11055,795,492 - 55,848,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01040,050,396 - 40,103,629 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11043,256,437 - 43,286,340 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1043,249,468 - 43,284,331 (+)Ensemblpanpan1.1panPan2
RET
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1283,946,132 - 3,995,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl283,947,232 - 3,994,210 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha284,180,472 - 4,211,554 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,124,929 - 4,176,146 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,126,037 - 4,174,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1283,922,935 - 3,954,018 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,965,997 - 3,997,076 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,100,288 - 4,131,400 (-)NCBIUU_Cfam_GSD_1.0
Ret
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721383,803,446 - 83,856,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366172,927,155 - 2,980,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366172,927,185 - 2,980,594 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RET
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1461,305,841 - 61,361,412 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11461,305,818 - 61,361,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21466,136,477 - 66,192,220 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RET
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1938,746,088 - 38,798,773 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl938,769,170 - 38,796,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605647,691,006 - 47,743,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ret
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624922382,399 - 413,281 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624922382,462 - 413,227 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2159
Count of miRNA genes:671
Interacting mature miRNAs:845
Transcripts:ENSMUST00000032201, ENSMUST00000088790
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
8552704Cia43_mcollagen induced arthritis QTL 43 (mouse)Not determined6114159241119737532Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined688982366122982564Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687480321121480516Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112246918125333748Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690772571124772807Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116641858128495988Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
4141699Ibdq2_minflammatory bowel disease QTL 2 (mouse)Not determined105982366120894102Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse

Markers in Region
Ret  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv376118,105,327 - 118,105,433UniSTSGRCm37
Celera6119,977,975 - 119,978,081UniSTS
Cytogenetic Map6E3-F1UniSTS
cM Map653.2UniSTS
Ret  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6E3-F1UniSTS
Ret  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6E3-F1UniSTS
Ret  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386118,155,309 - 118,155,415UniSTSGRCm38
MGSCv376118,105,327 - 118,105,433UniSTSGRCm37
Celera6119,977,975 - 119,978,081UniSTS
Cytogenetic Map6E3-F1UniSTS
cM Map653.2UniSTS
Ret  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6E3-F1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001080780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC135861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC156396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF209436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ294795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ294796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ294797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY255629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY326397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY965057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000032201   ⟹   ENSMUSP00000032201
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6118,128,706 - 118,174,094 (-)Ensembl
GRCm38.p6 Ensembl6118,151,745 - 118,197,133 (-)Ensembl
Ensembl Acc Id: ENSMUST00000088790   ⟹   ENSMUSP00000086169
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6118,131,527 - 118,174,679 (-)Ensembl
GRCm38.p6 Ensembl6118,154,566 - 118,197,718 (-)Ensembl
RefSeq Acc Id: NM_001080780   ⟹   NP_001074249
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396118,128,709 - 118,174,705 (-)NCBI
GRCm386118,151,748 - 118,197,744 (-)ENTREZGENE
MGSCv376118,101,766 - 118,147,762 (-)RGD
Celera6119,974,414 - 120,020,450 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_009050   ⟹   NP_033076
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396118,128,709 - 118,174,705 (-)NCBI
GRCm386118,151,748 - 118,197,744 (-)ENTREZGENE
MGSCv376118,101,766 - 118,147,762 (-)RGD
Celera6119,974,414 - 120,020,450 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001074249   ⟸   NM_001080780
- Peptide Label: isoform c precursor
- UniProtKB: P35546 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_033076   ⟸   NM_009050
- Peptide Label: isoform a precursor
- UniProtKB: Q8BQ34 (UniProtKB/Swiss-Prot),   Q9QXH9 (UniProtKB/Swiss-Prot),   P35546 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000032201   ⟸   ENSMUST00000032201
Ensembl Acc Id: ENSMUSP00000086169   ⟸   ENSMUST00000088790
Protein Domains
Cadherin   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35546-F1-model_v2 AlphaFold P35546 1-1115 view protein structure

Promoters
RGD ID:6890800
Promoter ID:EPDNEW_M8851
Type:initiation region
Name:Ret_2
Description:Mus musculus ret proto-oncogene , transcript variant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8852  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386118,197,366 - 118,197,426EPDNEW
RGD ID:6890802
Promoter ID:EPDNEW_M8852
Type:single initiation site
Name:Ret_1
Description:Mus musculus ret proto-oncogene , transcript variant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8851  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386118,197,676 - 118,197,736EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97902 AgrOrtholog
Ensembl Genes ENSMUSG00000030110 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032201 ENTREZGENE
  ENSMUST00000032201.8 UniProtKB/Swiss-Prot
  ENSMUST00000088790 ENTREZGENE
  ENSMUST00000088790.9 UniProtKB/Swiss-Prot
Gene3D-CATH Cadherins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Cadherin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ret_CLD1 UniProtKB/Swiss-Prot
  Ret_CLD3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RET_CLD4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_Ret_rcpt UniProtKB/Swiss-Prot
KEGG Report mmu:19713 UniProtKB/Swiss-Prot
MGD MGI:97902 ENTREZGENE
NCBI Gene 19713 ENTREZGENE
PANTHER PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RET_CLD1 UniProtKB/Swiss-Prot
  RET_CLD3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RET_CLD4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RET_CRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ret PhenoGen
PIRSF TyrPK_receptor_Ret UniProtKB/Swiss-Prot
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE CADHERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
SMART TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P35546 ENTREZGENE
  Q80YG6_MOUSE UniProtKB/TrEMBL
  Q8BQ34 ENTREZGENE
  Q8C8Q7_MOUSE UniProtKB/TrEMBL
  Q9QXH9 ENTREZGENE
  RET_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8BQ34 UniProtKB/Swiss-Prot
  Q9QXH9 UniProtKB/Swiss-Prot