Ret (ret proto-oncogene) - Rat Genome Database

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Gene: Ret (ret proto-oncogene) Ictidomys tridecemlineatus
Analyze
Symbol: Ret
Name: ret proto-oncogene
RGD ID: 12552470
Description: ENCODES a protein that exhibits ATP binding (inferred); calcium ion binding (inferred); kinase activity (inferred); INVOLVED IN cell surface receptor protein tyrosine kinase signaling pathway (ortholog); embryonic epithelial tube formation (ortholog); enteric nervous system development (ortholog); ASSOCIATED WITH appendicitis (ortholog); Brain Injuries (ortholog); brain ischemia (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); early endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proto-oncogene tyrosine-protein kinase receptor Ret; ret proto-oncogene, transcript variant X1; ret proto-oncogene, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721383,803,446 - 83,856,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366172,927,155 - 2,980,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366172,927,185 - 2,980,594 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
appendicitis  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Burkitt lymphoma  (ISO)
CAKUT  (ISO)
clubfoot  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital central hypoventilation syndrome  (ISO)
Constipation  (ISO)
Deafness  (ISO)
diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  (ISO)
disease of cellular proliferation  (ISO)
Dwarfism  (ISO)
extraosseous Ewing sarcoma  (ISO)
Facial Nerve Injuries  (ISO)
Familial Amyloidosis  (ISO)
familial medullary thyroid carcinoma  (ISO)
genetic disease  (ISO)
gingival overgrowth  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hirschsprung Disease 1  (ISO)
Hirschsprung's disease  (ISO)
Hypertelorism  (ISO)
Hypoglossal Nerve Injuries  (ISO)
hypothyroidism  (ISO)
Islet Cell Tumor Syndrome  (ISO)
Joint Instability  (ISO)
Lymphatic Metastasis  (ISO)
Medullary Carcinomas  (ISO)
medulloblastoma  (ISO)
megacolon  (ISO)
microcephaly  (ISO)
multiple endocrine neoplasia  (ISO)
multiple endocrine neoplasia type 1  (ISO)
multiple endocrine neoplasia type 2A  (ISO)
multiple endocrine neoplasia type 2B  (ISO)
multiple endocrine neoplasia type 4  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
Parkinsonism  (ISO)
pheochromocytoma  (ISO)
pilocytic astrocytoma  (ISO)
renal agenesis  (ISO)
Renal Hypodysplasia/Aplasia 1  (ISO)
renal hypoplasia  (ISO)
status epilepticus  (ISO)
tetralogy of Fallot  (ISO)
thyroid gland carcinoma  (ISO)
thyroid gland medullary carcinoma  (ISO)
thyroid gland papillary carcinoma  (ISO)
Thyroid Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell adhesion  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA,ISO)
cellular response to retinoic acid  (IEA)
embryonic epithelial tube formation  (IEA,ISO)
enteric nervous system development  (IEA,ISO)
glial cell-derived neurotrophic factor receptor signaling pathway  (IEA)
homophilic cell adhesion via plasma membrane adhesion molecules  (IEA)
innervation  (ISO)
MAPK cascade  (IEA,ISO)
membrane protein proteolysis  (IEA)
nervous system development  (IEA,ISO)
neural crest cell migration  (IEA,ISO)
neuron cell-cell adhesion  (IEA)
neuron differentiation  (IEA,ISO)
neuron maturation  (IEA,ISO)
Peyer's patch morphogenesis  (IEA)
positive regulation of cell adhesion mediated by integrin  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell size  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of MAPK cascade  (IEA)
positive regulation of metanephric glomerulus development  (IEA)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (IEA)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
regulation of axonogenesis  (IEA,ISO)
regulation of cell adhesion  (IEA)
regulation of peptidyl-serine phosphorylation of STAT protein  (ISO)
response to pain  (IEA)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
ureter maturation  (IEA,ISO)
ureteric bud development  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ret
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721383,803,446 - 83,856,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366172,927,155 - 2,980,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366172,927,185 - 2,980,594 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RET
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381043,077,069 - 43,130,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1043,077,064 - 43,130,351 (+)EnsemblGRCh38hg38GRCh38
GRCh371043,572,517 - 43,625,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361042,892,523 - 42,945,805 (+)NCBINCBI36Build 36hg18NCBI36
Build 341042,892,532 - 42,944,955NCBI
Celera1039,575,663 - 39,628,954 (+)NCBICelera
Cytogenetic Map10q11.21NCBI
HuRef1040,098,756 - 40,151,896 (+)NCBIHuRef
CHM1_11043,611,715 - 43,665,000 (+)NCBICHM1_1
T2T-CHM13v2.01043,954,542 - 44,007,848 (+)NCBIT2T-CHM13v2.0
Ret
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396118,128,709 - 118,174,705 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6118,128,706 - 118,174,679 (-)EnsemblGRCm39 Ensembl
GRCm386118,151,748 - 118,197,744 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6118,151,745 - 118,197,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv376118,101,766 - 118,147,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366118,119,472 - 118,162,752 (-)NCBIMGSCv36mm8
Celera6119,974,414 - 120,020,450 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map655.86NCBI
Ret
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84152,998,344 - 153,040,556 (-)NCBIGRCr8
mRatBN7.24151,325,969 - 151,368,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4151,326,431 - 151,368,176 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4157,589,266 - 157,631,480 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04153,373,235 - 153,415,450 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04151,996,254 - 152,038,470 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04150,202,170 - 150,249,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,202,058 - 150,244,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04216,130,142 - 216,177,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,448,179 - 154,491,103 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14154,693,019 - 154,735,944 (-)NCBI
Celera4140,198,457 - 140,240,663 (-)NCBICelera
Cytogenetic Map4q42NCBI
Ret
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555461,221,995 - 1,253,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555461,221,995 - 1,252,147 (+)NCBIChiLan1.0ChiLan1.0
RET
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2855,790,324 - 55,866,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11055,795,492 - 55,848,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01040,050,396 - 40,103,629 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11043,256,437 - 43,286,340 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1043,249,468 - 43,284,331 (+)Ensemblpanpan1.1panPan2
RET
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1283,946,132 - 3,995,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl283,947,232 - 3,994,210 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha284,180,472 - 4,211,554 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,124,929 - 4,176,146 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,126,037 - 4,174,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1283,922,935 - 3,954,018 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,965,997 - 3,997,076 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,100,288 - 4,131,400 (-)NCBIUU_Cfam_GSD_1.0
RET
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1461,305,841 - 61,361,412 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11461,305,818 - 61,361,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21466,136,477 - 66,192,220 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RET
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1938,746,088 - 38,798,773 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl938,769,170 - 38,796,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605647,691,006 - 47,743,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ret
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624922382,399 - 413,281 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624922382,462 - 413,227 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000001487   ⟹   ENSSTOP00000001331
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366172,927,155 - 2,980,602 (+)Ensembl
RefSeq Acc Id: XM_005334398   ⟹   XP_005334455
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721383,803,446 - 83,856,824 (-)NCBI
SpeTri2.0NW_0049366172,927,185 - 2,980,594 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005334455 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000001331.3
GenBank Protein KAG3265045 (Get FASTA)   NCBI Sequence Viewer  
  KAG3265046 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005334455   ⟸   XM_005334398
- UniProtKB: I3LYN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000001331   ⟸   ENSSTOT00000001487
Protein Domains
Cadherin   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001482 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001487.3 UniProtKB/TrEMBL
Gene3D-CATH Cadherins UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Cadherin-like_dom UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ret_CLD1 UniProtKB/TrEMBL
  Ret_CLD3 UniProtKB/TrEMBL
  RET_CLD4 UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_Ret_rcpt UniProtKB/TrEMBL
NCBI Gene Ret ENTREZGENE
PANTHER PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  RET_CLD1 UniProtKB/TrEMBL
  RET_CLD3 UniProtKB/TrEMBL
  RET_CLD4 UniProtKB/TrEMBL
PIRSF TyrPK_receptor_Ret UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE CADHERIN_2 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt I3LYN9 ENTREZGENE, UniProtKB/TrEMBL