RET (ret proto-oncogene) - Rat Genome Database

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Advanced Search (OLGA)
Gene: RET (ret proto-oncogene) Pan paniscus
Analyze
Symbol: RET
Name: ret proto-oncogene
RGD ID: 11748632
Description: ENCODES a protein that exhibits ATP binding (inferred); boss receptor activity (inferred); brain-derived neurotrophic factor receptor activity (inferred); INVOLVED IN cell surface receptor protein tyrosine kinase signaling pathway (ortholog); embryonic epithelial tube formation (ortholog); enteric nervous system development (ortholog); ASSOCIATED WITH appendicitis (ortholog); Brain Injuries (ortholog); brain ischemia (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); early endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proto-oncogene tyrosine-protein kinase receptor Ret
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2855,790,324 - 55,866,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11055,795,492 - 55,848,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01040,050,396 - 40,103,629 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11043,256,437 - 43,286,340 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1043,249,468 - 43,284,331 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
appendicitis  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Burkitt lymphoma  (ISO)
CAKUT  (ISO)
clubfoot  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital central hypoventilation syndrome  (ISO)
Constipation  (ISO)
Deafness  (ISO)
diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  (ISO)
disease of cellular proliferation  (ISO)
Dwarfism  (ISO)
extraosseous Ewing sarcoma  (ISO)
Facial Nerve Injuries  (ISO)
Familial Amyloidosis  (ISO)
familial medullary thyroid carcinoma  (ISO)
genetic disease  (ISO)
gingival overgrowth  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hirschsprung Disease 1  (ISO)
Hirschsprung's disease  (ISO)
Hypertelorism  (ISO)
Hypoglossal Nerve Injuries  (ISO)
hypothyroidism  (ISO)
Islet Cell Tumor Syndrome  (ISO)
Joint Instability  (ISO)
Lymphatic Metastasis  (ISO)
Medullary Carcinomas  (ISO)
medullary thyroid carcinoma  (ISO)
medulloblastoma  (ISO)
megacolon  (ISO)
microcephaly  (ISO)
multiple endocrine neoplasia  (ISO)
multiple endocrine neoplasia type 1  (ISO)
multiple endocrine neoplasia type 2A  (ISO)
multiple endocrine neoplasia type 2B  (ISO)
multiple endocrine neoplasia type 4  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
papillary thyroid carcinoma  (ISO)
Parkinsonism  (ISO)
pheochromocytoma  (ISO)
pilocytic astrocytoma  (ISO)
renal agenesis  (ISO)
Renal Hypodysplasia/Aplasia 1  (ISO)
renal hypoplasia  (ISO)
status epilepticus  (ISO)
tetralogy of Fallot  (ISO)
thyroid gland carcinoma  (ISO)
Thyroid Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
cell adhesion  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA,ISO)
cellular response to retinoic acid  (IEA)
chromatin remodeling  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
embryonic epithelial tube formation  (IEA,ISO)
enteric nervous system development  (IEA,ISO)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA)
GDF15-GFRAL signaling pathway  (IEA)
glial cell-derived neurotrophic factor receptor signaling pathway  (IEA)
hepatocyte growth factor receptor signaling pathway  (IEA)
homophilic cell adhesion via plasma membrane adhesion molecules  (IEA)
innervation  (ISO)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
macrophage colony-stimulating factor signaling pathway  (IEA)
MAPK cascade  (IEA,ISO)
membrane protein proteolysis  (IEA)
nervous system development  (IEA,ISO)
neural crest cell migration  (IEA,ISO)
neuron cell-cell adhesion  (IEA)
neuron differentiation  (IEA,ISO)
neuron maturation  (IEA,ISO)
Peyer's patch morphogenesis  (IEA)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of cell adhesion mediated by integrin  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell size  (IEA,ISO)
positive regulation of cysteine-type endopeptidase activity  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of MAPK cascade  (IEA)
positive regulation of metanephric glomerulus development  (IEA)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (IEA)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
regulation of axonogenesis  (IEA,ISO)
regulation of cell adhesion  (IEA)
response to pain  (IEA)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
ureter maturation  (IEA,ISO)
ureteric bud development  (IEA,ISO)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RET
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2855,790,324 - 55,866,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11055,795,492 - 55,848,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01040,050,396 - 40,103,629 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11043,256,437 - 43,286,340 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1043,249,468 - 43,284,331 (+)Ensemblpanpan1.1panPan2
RET
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381043,077,069 - 43,130,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1043,077,064 - 43,130,351 (+)EnsemblGRCh38hg38GRCh38
GRCh371043,572,517 - 43,625,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361042,892,523 - 42,945,805 (+)NCBINCBI36Build 36hg18NCBI36
Build 341042,892,532 - 42,944,955NCBI
Celera1039,575,663 - 39,628,954 (+)NCBICelera
Cytogenetic Map10q11.21NCBI
HuRef1040,098,756 - 40,151,896 (+)NCBIHuRef
CHM1_11043,611,715 - 43,665,000 (+)NCBICHM1_1
T2T-CHM13v2.01043,954,542 - 44,007,848 (+)NCBIT2T-CHM13v2.0
Ret
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396118,128,709 - 118,174,705 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6118,128,706 - 118,174,679 (-)EnsemblGRCm39 Ensembl
GRCm386118,151,748 - 118,197,744 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6118,151,745 - 118,197,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv376118,101,766 - 118,147,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366118,119,472 - 118,162,752 (-)NCBIMGSCv36mm8
Celera6119,974,414 - 120,020,450 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map655.86NCBI
Ret
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84152,998,344 - 153,040,556 (-)NCBIGRCr8
mRatBN7.24151,325,969 - 151,368,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4151,326,431 - 151,368,176 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4157,589,266 - 157,631,480 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04153,373,235 - 153,415,450 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04151,996,254 - 152,038,470 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04150,202,170 - 150,249,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,202,058 - 150,244,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04216,130,142 - 216,177,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44154,448,179 - 154,491,103 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14154,693,019 - 154,735,944 (-)NCBI
Celera4140,198,457 - 140,240,663 (-)NCBICelera
Cytogenetic Map4q42NCBI
Ret
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555461,221,995 - 1,253,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555461,221,995 - 1,252,147 (+)NCBIChiLan1.0ChiLan1.0
RET
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1283,946,132 - 3,995,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl283,947,232 - 3,994,210 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha284,180,472 - 4,211,554 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,124,929 - 4,176,146 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,126,037 - 4,174,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1283,922,935 - 3,954,018 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,965,997 - 3,997,076 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,100,288 - 4,131,400 (-)NCBIUU_Cfam_GSD_1.0
Ret
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721383,803,446 - 83,856,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366172,927,155 - 2,980,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366172,927,185 - 2,980,594 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RET
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1461,305,841 - 61,361,412 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11461,305,818 - 61,361,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21466,136,477 - 66,192,220 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RET
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1938,746,088 - 38,798,773 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl938,769,170 - 38,796,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605647,691,006 - 47,743,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ret
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624922382,399 - 413,281 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624922382,462 - 413,227 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000044522   ⟹   ENSPPAP00000021719
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1043,249,468 - 43,283,566 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044529   ⟹   ENSPPAP00000021726
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1043,252,271 - 43,284,331 (+)Ensembl
RefSeq Acc Id: XM_034930365   ⟹   XP_034786256
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2855,790,324 - 55,866,889 (+)NCBI
NHGRI_mPanPan11055,795,492 - 55,848,773 (+)NCBI
Mhudiblu_PPA_v01040,050,396 - 40,103,629 (+)NCBI
RefSeq Acc Id: XM_055092672   ⟹   XP_054948647
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2855,790,324 - 55,840,582 (+)NCBI
NHGRI_mPanPan11055,795,492 - 55,845,911 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034786256 (Get FASTA)   NCBI Sequence Viewer  
  XP_054948647 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000021719.1
  ENSPPAP00000021726.1
RefSeq Acc Id: XP_034786256   ⟸   XM_034930365
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B0Q5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000021719   ⟸   ENSPPAT00000044522
Ensembl Acc Id: ENSPPAP00000021726   ⟸   ENSPPAT00000044529
RefSeq Acc Id: XP_054948647   ⟸   XM_055092672
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AWY2 (UniProtKB/TrEMBL)
Protein Domains
Cadherin   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034047 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000044522.1 UniProtKB/TrEMBL
  ENSPPAT00000044529.1 UniProtKB/TrEMBL
Gene3D-CATH Cadherins UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Cadherin-like_dom UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ret_CLD1 UniProtKB/TrEMBL
  Ret_CLD3 UniProtKB/TrEMBL
  RET_CLD4 UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_Ret_rcpt UniProtKB/TrEMBL
NCBI Gene RET ENTREZGENE
PANTHER PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  RET_CLD1 UniProtKB/TrEMBL
  RET_CLD3 UniProtKB/TrEMBL
  RET_CLD4 UniProtKB/TrEMBL
  RET_CRD UniProtKB/TrEMBL
PIRSF TyrPK_receptor_Ret UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE CADHERIN_2 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9AWY2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B0Q5 ENTREZGENE, UniProtKB/TrEMBL