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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3556
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ret
Name: ret proto-oncogene
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Retincreases activityISORET (Homo sapiens)6480464CTDArsenic results in increased activity of RET protein; Arsenic results in increased activity of RET protein alternative formPMID:21195159
Retmultiple interactionsISORET (Homo sapiens)6480464CTD[Arsenic co-treated with RET protein alternative form] results in increased secretion of MMP2 protein alternative form; [Arsenic co-treated with RET protein] results in increased secretion of MMP2 protein alternative form; Arsenic promotes the reaction [RET protein alternative form binds to RET protein alternative form]; Cysteine inhibits the reaction [[Arsenic co-treated with RET protein] results in increased secretion of MMP2 protein alternative form]PMID:21195159
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