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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3556
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ret
Name: ret proto-oncogene
Acc ID: CHEBI:8502
Term: 6-propyl-2-thiouracil
Definition: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.
Chemical ID: MESH:D011441
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Retdecreases expressionEXP 6480464CTDPropylthiouracil results in decreased expression of RET mRNAPMID:30047161
Retincreases expressionEXP 6480464CTDPropylthiouracil results in increased expression of RET mRNA; Propylthiouracil results in increased expression of RET proteinPMID:22504374 PMID:24780913 PMID:25825206
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