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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3556
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ret
Name: ret proto-oncogene
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Retdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of RET mRNAPMID:12075121 PMID:25181051 PMID:30816183 PMID:32528016 PMID:34947998
Retdecreases methylationISORet (Mus musculus)6480464CTDbisphenol A results in decreased methylation of RET promoterPMID:27312807
Retincreases expressionISORet (Mus musculus)6480464CTDbisphenol A results in increased expression of RET mRNAPMID:27312807 PMID:30951980 PMID:32156529
Retincreases expressionISORET (Homo sapiens)6480464CTDbisphenol A results in increased expression of RET mRNAPMID:28711546
Retincreases methylationISORet (Mus musculus)6480464CTDbisphenol A results in increased methylation of RET promoterPMID:27312807
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