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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3556
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ret
Name: ret proto-oncogene
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Retdecreases expressionEXP 6480464CTDValproic Acid results in decreased expression of RET mRNAPMID:33150595
Retincreases methylationEXP 6480464CTDValproic Acid results in increased methylation of RET promoterPMID:33150595
Retmultiple interactionsEXP 6480464CTD[Valproic Acid co-treated with Vitamin A deficiency] affects the expression of RET protein; [Valproic Acid co-treated with Vitamin A deficiency] affects the reaction [RARA protein binds to RET promoter]PMID:32526256
Retaffects expressionISORet (Mus musculus)6480464CTDValproic Acid affects the expression of RET mRNAPMID:17963808
Retaffects expressionISORET (Homo sapiens)6480464CTDValproic Acid affects the expression of RET mRNAPMID:25979313
Retincreases expressionISORET (Homo sapiens)6480464CTDValproic Acid results in increased expression of RET mRNAPMID:23179753 PMID:24935251 PMID:26272509 PMID:28001369
Retincreases methylationISORET (Homo sapiens)6480464CTDValproic Acid results in increased methylation of RET genePMID:29154799
Retmultiple interactionsISORET (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RET mRNAPMID:27188386
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