Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


RGD ID: 2681
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gfra1
Name: GDNF family receptor alpha 1
Acc ID: CHEBI:10650
Term: sumatriptan
Definition: A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
Chemical ID: MESH:D018170
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gfra1multiple interactionsEXP 6480464CTD[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA1 protein] Sumatriptan inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]

Go Back to source page   Continue to Ontology report