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Gene: Gdnf (glial cell derived neurotrophic factor) Rattus norvegicus
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Symbol: Gdnf
Name: glial cell derived neurotrophic factor
Description: Exhibits protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including animal organ development; cellular response to dexamethasone stimulus; and regulation of mesonephros development. Localizes to the extracellular space and receptor complex. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in Hirschsprung's disease; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Orthologous to human GDNF (glial cell derived neurotrophic factor); INTERACTS WITH (+)-pilocarpine; (R)-Salsolinol; (S)-AMPA.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: astrocyte-derived trophic factor; ATF; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; glial cell line-derived neurotrophic factor; GNDF
Orthologs:
Homo sapiens (human) : GDNF (glial cell derived neurotrophic factor)  HGNC  Alliance
Mus musculus (house mouse) : Gdnf (glial cell line derived neurotrophic factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gdnf (glial cell derived neurotrophic factor)
Pan paniscus (bonobo/pygmy chimpanzee) : GDNF (glial cell derived neurotrophic factor)
Canis lupus familiaris (dog) : GDNF (glial cell derived neurotrophic factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gdnf (glial cell derived neurotrophic factor)
Sus scrofa (pig) : GDNF (glial cell derived neurotrophic factor)
Chlorocebus sabaeus (African green monkey) : GDNF (glial cell derived neurotrophic factor)
Heterocephalus glaber (naked mole-rat) : Gdnf (glial cell derived neurotrophic factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0256,884,181 - 56,912,964 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl256,887,987 - 56,910,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0276,896,991 - 76,922,471 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4257,399,312 - 57,424,030 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1257,327,544 - 57,352,263 (+)NCBI
Celera252,510,468 - 52,532,694 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Gdnf
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2677
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.