As3mt (arsenite methyltransferase) - Rat Genome Database

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Gene: As3mt (arsenite methyltransferase) Rattus norvegicus
Analyze
Symbol: As3mt
Name: arsenite methyltransferase
RGD ID: 621325
Description: Enables arsenite methyltransferase activity. Involved in arsonoacetate metabolic process and toxin metabolic process. Acts upstream of or within response to arsenic-containing substance. Located in cytosol. Orthologous to human AS3MT (arsenite methyltransferase); PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathway; INTERACTS WITH 1,4-dithiothreitol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arsenic (+3 oxidation state) methyltransferase; Cyt19; methylarsonite methyltransferase; methyltransferase Cyt19; S-adenosyl-L-methionine:arsenic(III) methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Candidate Gene For: Rf1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,536,879 - 255,569,245 (+)NCBIGRCr8
mRatBN7.21245,595,939 - 245,628,921 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,596,108 - 245,627,872 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,723,062 - 253,755,177 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01260,417,406 - 260,449,225 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01253,065,883 - 253,097,650 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,482,787 - 266,514,570 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,482,858 - 266,514,569 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,913,062 - 273,945,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41252,029,638 - 252,061,352 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11252,292,792 - 252,324,506 (+)NCBI
Celera1241,368,780 - 241,399,852 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsane  (EXP,ISO)
arsenic acid  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite ion  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
Aurothioglucose  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
butanal  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
glutathione  (EXP,ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
irinotecan  (EXP)
ivermectin  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-cysteine  (ISO)
methylarsonic acid  (ISO)
methylarsonite  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (ISO)
proanthocyanidin  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
TCEP  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
triazines  (ISO)
trimethylarsine  (EXP)
trimethylarsine oxide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol. Lin S, etal., J Biol Chem 2002 Mar 29;277(13):10795-803.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Elucidating the pathway for arsenic methylation. Thomas DJ, etal., Toxicol Appl Pharmacol. 2004 Aug 1;198(3):319-26.
Additional References at PubMed
PMID:12477932   PMID:15606138   PMID:15808521   PMID:18614015   PMID:25997655   PMID:31505169  


Genomics

Comparative Map Data
As3mt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,536,879 - 255,569,245 (+)NCBIGRCr8
mRatBN7.21245,595,939 - 245,628,921 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,596,108 - 245,627,872 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,723,062 - 253,755,177 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01260,417,406 - 260,449,225 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01253,065,883 - 253,097,650 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,482,787 - 266,514,570 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,482,858 - 266,514,569 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,913,062 - 273,945,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41252,029,638 - 252,061,352 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11252,292,792 - 252,324,506 (+)NCBI
Celera1241,368,780 - 241,399,852 (+)NCBICelera
Cytogenetic Map1q54NCBI
AS3MT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,869,470 - 102,901,899 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,869,470 - 102,901,899 (+)EnsemblGRCh38hg38GRCh38
GRCh3710104,629,227 - 104,661,656 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,619,200 - 104,651,646 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410104,619,262 - 104,651,643NCBI
Celera1098,369,790 - 98,401,891 (+)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1098,263,978 - 98,296,045 (+)NCBIHuRef
CHM1_110104,912,421 - 104,944,505 (+)NCBICHM1_1
T2T-CHM13v2.010103,755,254 - 103,787,669 (+)NCBIT2T-CHM13v2.0
As3mt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,695,124 - 46,729,538 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,695,897 - 46,729,538 (+)EnsemblGRCm39 Ensembl
GRCm381946,707,157 - 46,741,099 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,707,458 - 46,741,099 (+)EnsemblGRCm38mm10GRCm38
MGSCv371946,781,933 - 46,815,585 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,760,784 - 46,794,383 (+)NCBIMGSCv36mm8
Celera1947,477,252 - 47,510,537 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.97NCBI
As3mt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554857,575,580 - 7,599,559 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554857,576,627 - 7,599,005 (-)NCBIChiLan1.0ChiLan1.0
AS3MT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28114,754,257 - 114,788,919 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110114,759,814 - 114,794,242 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01099,470,026 - 99,502,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110102,933,503 - 102,964,692 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10102,933,671 - 102,964,692 (+)Ensemblpanpan1.1panPan2
AS3MT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12815,334,141 - 15,350,749 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2815,503,892 - 15,522,525 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02815,806,818 - 15,825,455 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,788,533 - 15,990,025 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12815,350,453 - 15,369,076 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02815,389,645 - 15,408,259 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,522,659 - 15,541,286 (+)NCBIUU_Cfam_GSD_1.0
As3mt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721331,447,159 - 31,466,576 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,051,129 - 3,069,690 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366003,050,946 - 3,069,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AS3MT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,847,859 - 113,869,507 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114113,844,107 - 113,867,880 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,816,442 - 123,853,246 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AS3MT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,911,465 - 95,939,554 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl995,912,086 - 95,939,375 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604857,023,327 - 57,052,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in As3mt
181 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:186
Interacting mature miRNAs:206
Transcripts:ENSRNOT00000027223
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat

Markers in Region
RH135042  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,627,576 - 245,627,764 (+)MAPPERmRatBN7.2
Rnor_6.01266,514,287 - 266,514,474NCBIRnor6.0
Rnor_5.01273,945,111 - 273,945,298UniSTSRnor5.0
RGSC_v3.41252,061,069 - 252,061,256UniSTSRGSC3.4
Celera1241,399,569 - 241,399,756UniSTS
RH 3.4 Map11628.9UniSTS
Cytogenetic Map1q54UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 56 41 18 41 8 9 27 31 34 11 8
Low 1 1 2 47 4 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000027223   ⟹   ENSRNOP00000027223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,596,108 - 245,627,872 (+)Ensembl
Rnor_6.0 Ensembl1266,482,858 - 266,514,569 (+)Ensembl
RefSeq Acc Id: NM_080890   ⟹   NP_543166
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,537,511 - 255,569,245 (+)NCBI
mRatBN7.21245,596,116 - 245,627,860 (+)NCBI
Rnor_6.01266,482,858 - 266,514,570 (+)NCBI
Rnor_5.01273,913,062 - 273,945,394 (+)NCBI
RGSC_v3.41252,029,638 - 252,061,352 (+)RGD
Celera1241,368,780 - 241,399,852 (+)RGD
Sequence:
RefSeq Acc Id: XM_039082665   ⟹   XP_038938593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,536,879 - 255,563,832 (+)NCBI
mRatBN7.21245,595,952 - 245,628,921 (+)NCBI
RefSeq Acc Id: XM_039082696   ⟹   XP_038938624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,536,879 - 255,569,243 (+)NCBI
mRatBN7.21245,595,939 - 245,627,860 (+)NCBI
RefSeq Acc Id: XM_063271150   ⟹   XP_063127220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,536,879 - 255,568,672 (+)NCBI
RefSeq Acc Id: XM_063271221   ⟹   XP_063127291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,536,879 - 255,555,231 (+)NCBI
RefSeq Acc Id: NP_543166   ⟸   NM_080890
- UniProtKB: Q8VHT6 (UniProtKB/Swiss-Prot),   G3V8P2 (UniProtKB/TrEMBL),   A6JHN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027223   ⟸   ENSRNOT00000027223
RefSeq Acc Id: XP_038938624   ⟸   XM_039082696
- Peptide Label: isoform X3
- UniProtKB: Q8VHT6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038938593   ⟸   XM_039082665
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063127220   ⟸   XM_063271150
- Peptide Label: isoform X2
- UniProtKB: Q8VHT6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063127291   ⟸   XM_063271221
- Peptide Label: isoform X4
- UniProtKB: A6JHN8 (UniProtKB/TrEMBL)
Protein Domains
Methyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VHT6-F1-model_v2 AlphaFold Q8VHT6 1-369 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690973
Promoter ID:EPDNEW_R1497
Type:initiation region
Name:As3mt_1
Description:arsenite methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01266,482,827 - 266,482,887EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621325 AgrOrtholog
BioCyc Gene G2FUF-55498 BioCyc
Ensembl Genes ENSRNOG00000020081 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00060029581 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027223.7 UniProtKB/TrEMBL
  ENSRNOT00060051439 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.5.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6918024 IMAGE-MGC_LOAD
InterPro Arsenite_MeTrfase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyltranfer_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140925 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72713 IMAGE-MGC_LOAD
NCBI Gene 140925 ENTREZGENE
PANTHER ARSENITE METHYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43675 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Methyltransf_31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AS3MT RGD
PhenoGen As3mt PhenoGen
RatGTEx ENSRNOG00000020081 RatGTEx
  ENSRNOG00060029581 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JHN7 ENTREZGENE, UniProtKB/TrEMBL
  A6JHN8 ENTREZGENE, UniProtKB/TrEMBL
  A6JHN9_RAT UniProtKB/TrEMBL
  AS3MT_RAT UniProtKB/Swiss-Prot
  G3V8P2 ENTREZGENE, UniProtKB/TrEMBL
  Q6P7S7_RAT UniProtKB/TrEMBL
  Q8VHT6 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-05-21 As3mt  arsenite methyltransferase  As3mt  arsenic (+3 oxidation state) methyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-01-30 As3mt  arsenic (+3 oxidation state) methyltransferase  Cyt19    Data merged from RGD:1354668 737654 APPROVED
2005-01-20 As3mt  arsenic (+3 oxidation state) methyltransferase  Cyt19  methyltransferase Cyt19  Symbol and Name updated 1299863 APPROVED
2002-08-07 Cyt19  methyltransferase Cyt19      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 369-amino acid residues and a molecular mass of 4,1056 625365