Scd (stearoyl-CoA desaturase) - Rat Genome Database

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Gene: Scd (stearoyl-CoA desaturase) Rattus norvegicus
Analyze
Symbol: Scd
Name: stearoyl-CoA desaturase
RGD ID: 621176
Description: Enables iron ion binding activity and stearoyl-CoA 9-desaturase activity. Involved in response to fatty acid and unsaturated fatty acid biosynthetic process. Located in intracellular membrane-bounded organelle and membrane. Used to study carcinoma. Biomarker of hyperinsulinism. Orthologous to human SCD (stearoyl-CoA desaturase); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH (+)-catechin; (-)-epigallocatechin 3-gallate; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acyl-CoA desaturase 1; delta(9)-desaturase 1; delta-9 desaturase 1; fatty acid desaturase 1; Scd1; stearoyl-CoA desaturase 1; stearoyl-Coenzyme A desaturase 1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21243,269,745 - 243,282,878 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,269,747 - 243,282,562 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,420,000 - 251,432,600 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01258,116,587 - 258,129,187 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01250,770,154 - 250,782,754 (-)NCBIRnor_WKY
Rnor_6.01264,159,966 - 264,173,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,160,129 - 264,172,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,602,885 - 271,615,985 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,458,860 - 249,471,460 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11249,717,543 - 249,730,359 (-)NCBI
Celera1239,084,889 - 239,097,489 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(R)-noradrenaline  (EXP)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-nicotine  (ISO)
1,2,3-trilinolenoylglycerol  (ISO)
1,2,3-trilinoleoylglycerol  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
25-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (EXP)
5-fluorouracil  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
Actein  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
barium sulfate  (EXP)
benomyl  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzofurans  (ISO)
benzylpenicillin  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (EXP,ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
bupropion  (ISO)
buspirone  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
ceric oxide  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP,ISO)
chloroquine  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (ISO)
chrysene  (ISO)
chrysin  (ISO)
ciprofibrate  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clavulanic acid  (ISO)
clemizole  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clomipramine  (ISO)
clopidogrel  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
corticosterone  (EXP)
coumarin  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxypodophyllotoxin  (ISO)
desmosterol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
dihydrogen  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium  (ISO)
disodium selenite  (ISO)
diuron  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
Elemicin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
Ethyl icosapentate  (ISO)
ethyl methanesulfonate  (ISO)
farnesol  (ISO)
fenarimol  (EXP)
fenofibrate  (EXP,ISO)
ferulic acid  (ISO)
fipronil  (EXP)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gadolinium trichloride  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
glycerol 2-phosphate  (ISO)
glycidol  (EXP)
glycine betaine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
haloperidol  (ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (EXP,ISO)
Honokiol  (EXP)
hydrazine  (EXP)
hydrogen peroxide  (EXP)
imipramine  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
irinotecan  (ISO)
isobutanol  (ISO)
isoflavones  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
limonene  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
lutein  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
mercaptopurine  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
mirtazapine  (ISO)
Mitotane  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
octadecanoic acid  (EXP)
oleic acid  (ISO)
oroxylin A  (ISO)
orphenadrine  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
paxilline  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium bromate  (EXP)
potassium chromate  (ISO)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
procymidone  (ISO)
progesterone  (ISO)
propamocarb  (ISO)
propiconazole  (EXP,ISO)
purine-6-thiol  (EXP)
PX-866  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
ritodrine  (ISO)
rofecoxib  (ISO)
rotenone  (EXP)
sarin  (ISO)
saroglitazar  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (EXP,ISO)
Sodium oleate  (ISO)
starch  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
sulconazole  (ISO)
sulfluramid  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP,ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (EXP)
topiramate  (EXP)
topotecan  (ISO)
trans-caffeic acid  (ISO)
tremolite asbestos  (ISO)
triarachidonin  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclocarban  (EXP)
triclosan  (ISO)
triolein  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
Triton X-100  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vandetanib  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
yohimbine  (ISO)
zaragozic acid A  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. Falvella FS, etal., Carcinogenesis 2002 Nov;23(11):1933-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes. Heinemann FS, etal., J Biol Chem 2003 Oct 31;278(44):42966-75. Epub 2003 Aug 19.
4. Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. Lee SH, etal., J Lipid Res. 2004 Sep;45(9):1674-82. doi: 10.1194/jlr.M400039-JLR200. Epub 2004 Jun 21.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene. Mihara K J Biochem. 1990 Dec;108(6):1022-9.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis. Saether T, etal., Biol Reprod 2003 Jul;69(1):117-24. Epub 2003 Feb 19.
14. Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. Sampath H, etal., J Biol Chem. 2009 Jul 24;284(30):19961-73. doi: 10.1074/jbc.M109.014225. Epub 2009 May 8.
15. Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase. Shanklin J, etal., Biochemistry. 1994 Nov 1;33(43):12787-94.
16. Bacterial synthesis of active rat stearyl-CoA desaturase lacking the 26-residue amino-terminal amino acid sequence. Strittmatter P, etal., J Biol Chem. 1988 Feb 15;263(5):2532-5.
17. Construction and sequence of cDNA for rat liver stearyl coenzyme A desaturase. Thiede MA, etal., J Biol Chem 1986 Oct 5;261(28):13230-5.
18. Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: implications for a role of stearoyl-CoA desaturase 1 in insulin resistance. Voss MD, etal., Diabetologia. 2005 Dec;48(12):2622-30. Epub 2005 Nov 12.
19. Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase. Zhang F, etal., Am J Respir Cell Mol Biol 2004 Feb;30(2):174-83. Epub 2003 Aug 01.
Additional References at PubMed
PMID:10854228   PMID:10899171   PMID:12815040   PMID:14592417   PMID:15907797   PMID:16040962   PMID:16275639   PMID:16357064   PMID:16443825   PMID:16741579   PMID:16809433   PMID:18079124  
PMID:18364238   PMID:18492766   PMID:18665039   PMID:18765284   PMID:19777326   PMID:19787047   PMID:19946888   PMID:20721682   PMID:20732836   PMID:20847127   PMID:22047910   PMID:22871113  
PMID:23012479   PMID:23298201   PMID:23539346   PMID:26098370   PMID:26293158   PMID:27697525   PMID:27923787   PMID:29290651   PMID:30622312   PMID:32048626  


Genomics

Comparative Map Data
Scd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21243,269,745 - 243,282,878 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,269,747 - 243,282,562 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,420,000 - 251,432,600 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01258,116,587 - 258,129,187 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01250,770,154 - 250,782,754 (-)NCBIRnor_WKY
Rnor_6.01264,159,966 - 264,173,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,160,129 - 264,172,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,602,885 - 271,615,985 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,458,860 - 249,471,460 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11249,717,543 - 249,730,359 (-)NCBI
Celera1239,084,889 - 239,097,489 (-)NCBICelera
Cytogenetic Map1q54NCBI
SCD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,347,233 - 100,364,826 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10100,347,233 - 100,364,826 (+)EnsemblGRCh38hg38GRCh38
GRCh3710102,106,990 - 102,124,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610102,096,762 - 102,114,578 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410102,096,761 - 102,114,577NCBI
Celera1095,844,653 - 95,862,464 (+)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1095,735,654 - 95,753,465 (+)NCBIHuRef
CHM1_110102,391,212 - 102,409,039 (+)NCBICHM1_1
T2T-CHM13v2.010101,231,456 - 101,249,056 (+)NCBIT2T-CHM13v2.0
Scd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,382,889 - 44,396,148 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,382,894 - 44,396,318 (-)EnsemblGRCm39 Ensembl
GRCm381944,394,450 - 44,407,709 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,394,455 - 44,407,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv371944,468,940 - 44,482,199 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361944,447,766 - 44,460,864 (-)NCBIMGSCv36mm8
Celera1945,168,530 - 45,181,736 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1937.98NCBI
SCD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110100,428,627 - 100,446,647 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,429,615 - 100,442,776 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01096,948,212 - 96,965,633 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SCD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12813,112,741 - 13,129,129 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2813,113,006 - 13,125,801 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2813,283,628 - 13,300,028 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,581,765 - 13,598,163 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,581,805 - 13,598,155 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12813,128,503 - 13,144,867 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02813,166,524 - 13,182,907 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02813,300,894 - 13,317,236 (+)NCBIUU_Cfam_GSD_1.0
SCD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,461,569 - 111,478,020 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,461,560 - 111,478,033 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,964,681 - 120,980,911 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q27NCBI
SCD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,380,812 - 93,398,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl993,380,914 - 93,398,912 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604854,387,804 - 54,405,855 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Scd
73 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:536
Count of miRNA genes:263
Interacting mature miRNAs:336
Transcripts:ENSRNOT00000018447, ENSRNOT00000075397
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

Markers in Region
Scd1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,112,004 - 243,112,080 (+)MAPPERmRatBN7.2
mRatBN7.21243,273,354 - 243,273,430 (+)MAPPERmRatBN7.2
Rnor_6.01264,163,576 - 264,163,651NCBIRnor6.0
Rnor_6.01264,001,538 - 264,001,613NCBIRnor6.0
Rnor_5.01271,446,710 - 271,446,785UniSTSRnor5.0
Rnor_5.01271,606,495 - 271,606,570UniSTSRnor5.0
RGSC_v3.41249,462,307 - 249,462,382UniSTSRGSC3.4
Celera1239,088,336 - 239,088,411UniSTS
Celera1238,929,123 - 238,929,198UniSTS
Cytogenetic Map1q54UniSTS
UniSTS:498485  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,273,318 - 243,273,392 (+)MAPPERmRatBN7.2
Rnor_6.01264,163,540 - 264,163,613NCBIRnor6.0
Rnor_5.01271,606,459 - 271,606,532UniSTSRnor5.0
RGSC_v3.41249,462,271 - 249,462,344UniSTSRGSC3.4
Celera1239,088,300 - 239,088,373UniSTS
Cytogenetic Map1q54UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 12 8 1 8 1
Medium 3 5 37 28 16 28 6 6 62 15 21 11 6
Low 33 8 5 2 5 2 4 12 19 17 2
Below cutoff 5 1 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018447   ⟹   ENSRNOP00000018447
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1243,269,747 - 243,282,562 (-)Ensembl
Rnor_6.0 Ensembl1264,160,129 - 264,172,729 (-)Ensembl
RefSeq Acc Id: NM_139192   ⟹   NP_631931
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,269,908 - 243,282,508 (-)NCBI
Rnor_6.01264,160,129 - 264,172,729 (-)NCBI
Rnor_5.01271,602,885 - 271,615,985 (-)NCBI
RGSC_v3.41249,458,860 - 249,471,460 (-)RGD
Celera1239,084,889 - 239,097,489 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231433   ⟹   XP_006231495
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,269,745 - 243,282,878 (-)NCBI
Rnor_6.01264,159,966 - 264,173,061 (-)NCBI
Rnor_5.01271,602,885 - 271,615,985 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_631931   ⟸   NM_139192
- UniProtKB: Q8JZL5 (UniProtKB/Swiss-Prot),   P07308 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006231495   ⟸   XM_006231433
- Peptide Label: isoform X1
- UniProtKB: Q8JZL5 (UniProtKB/Swiss-Prot),   P07308 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018447   ⟸   ENSRNOT00000018447

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07308-F1-model_v2 AlphaFold P07308 1-358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690939
Promoter ID:EPDNEW_R1464
Type:single initiation site
Name:Scd_1
Description:stearoyl-CoA desaturase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01264,172,797 - 264,172,857EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621176 AgrOrtholog
BioCyc Gene G2FUF-55589 BioCyc
BioCyc Pathway PWY-5996 [oleate biosynthesis II (animals and fungi)] BioCyc
  PWY3O-1801 [palmitoleate biosynthesis IV (fungi and animals)] BioCyc
Ensembl Genes ENSRNOG00000013552 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000018447 ENTREZGENE
  ENSRNOP00000018447.3 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018447 ENTREZGENE
  ENSRNOT00000018447.6 UniProtKB/Swiss-Prot
InterPro Acyl-CoA_DS UniProtKB/Swiss-Prot
  FA_desaturase_dom UniProtKB/Swiss-Prot
  FADS-1_CS UniProtKB/Swiss-Prot
KEGG Report rno:246074 UniProtKB/Swiss-Prot
NCBI Gene 246074 ENTREZGENE
PANTHER ACYL-COA DESATURASE 1 UniProtKB/Swiss-Prot
  PTHR11351 UniProtKB/Swiss-Prot
Pfam FA_desaturase UniProtKB/Swiss-Prot
PhenoGen Scd PhenoGen
PRINTS FACDDSATRASE UniProtKB/Swiss-Prot
PROSITE FATTY_ACID_DESATUR_1 UniProtKB/Swiss-Prot
UniProt ACOD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8JZL5 ENTREZGENE
UniProt Secondary Q8JZL5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Scd  stearoyl-CoA desaturase  Scd1  stearoyl-Coenzyme A desaturase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Scd1  stearoyl-Coenzyme A desaturase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Scd1  stearoyl-Coenzyme A desaturase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression is associated with genetic predisposition to hepatocarcinogenesis 633981
gene_regulation expression is increased by peroxisome proliferators, iron overload and dichloroacetic acid 633981