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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:17489
Term: 3',5'-cyclic AMP
Definition: A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase.
Chemical ID: MESH:D000242
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDADRB1 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]

PMID:18378355
affects abundanceISORGD:7312896480464CTDADRB1 protein affects the abundance of Cyclic AMP

ADRB1 protein polymorphism affects the abundance of Cyclic AMP

PMID:14502278, PMID:14730417
increases abundanceISORGD:7312896480464CTDADRB1 protein results in increased abundance of Cyclic AMP

PMID:11562432, PMID:18787115
multiple interactionsISORGD:7312896480464CTD[3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP

[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP

[Alprenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

[Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

[Atenolol co-treated with ADRB1] results in increased abundance of Cyclic AMP

[Bisoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

[Bupranolol co-treated with ADRB1] results in increased abundance of Cyclic AMP

[Carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

[Carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP

[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP

[CGP 12177 binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

[CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP

[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]

[Epinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP

[Fenoterol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP

[Formoterol Fumarate binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP

[ICI 118551 binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

[Isoproterenol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP

[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP

[Metoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

[Norepinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP

[Pindolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

[Propranolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

[Propranolol co-treated with ADRB1] results in increased abundance of Cyclic AMP

[Salmeterol Xinafoate binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

ADRB1 protein polymorphism affects the reaction [[Carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP]

Alprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

Bisoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

Bupranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

Carvedilol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

CGP 20712A inhibits the reaction [[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP]

CGP 20712A inhibits the reaction [[Carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP]

CGP 20712A inhibits the reaction [[CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP]

CGP 20712A inhibits the reaction [[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP]

Isoproterenol promotes the reaction [ADRB1 protein results in increased abundance of Cyclic AMP]

Metoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

Nadolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

Oxprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

Pindolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

Propranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

Sotalol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

PMID:12761341, PMID:14730417, PMID:15060759, PMID:17200720, PMID:18787115, PMID:19419905
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.