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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:9449
Term: terbutaline
Definition: A member of the class of phenylethanolamines that is catechol substuted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.
Chemical ID: MESH:D013726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDTerbutaline inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

PMID:8096834
multiple interactionsISORGD:7312896480464CTDTerbutaline binds to and results in decreased activity of ADRB1 protein

Terbutaline binds to and results in increased activity of ADRB1 protein mutant form

Terbutaline inhibits the reaction [cyanopindolol binds to ADRB1 protein]

Terbutaline inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

PMID:14730417, PMID:16648137, PMID:8096834
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.