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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:18357
Term: (R)-noradrenaline
Definition: The R-enantiomer of noradrenaline.
Chemical ID: MESH:D009638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDNorepinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

PMID:8096834
multiple interactionsISORGD:101066480464CTD[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Norepinephrine

PMID:12010770
multiple interactionsISORGD:7312896480464CTD[Norepinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP

Norepinephrine binds to and results in increased activity of ADRB1 protein

Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]

Norepinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Norepinephrine promotes the reaction [ADRB1 protein results in increased activity of GNAS protein]

Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein]

Propranolol inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRB1 protein]

PMID:10344530, PMID:14730417, PMID:17200720, PMID:8096834
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.