GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:6904
Term: metoprolol
Definition: A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Chemical ID: MESH:D008790
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDMetoprolol binds to ADRB1 protein

PMID:9593075
decreases methylationEXP 6480464CTDMetoprolol results in decreased methylation of ADRB1 promoter

PMID:22165287
increases expressionEXP 6480464CTDMetoprolol results in increased expression of ADRB1 mRNA

Metoprolol results in increased expression of ADRB1 protein

PMID:18703049, PMID:22165287
multiple interactionsEXP 6480464CTDMetoprolol binds to and results in increased activity of ADRB1 protein

Metoprolol inhibits the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]

Metoprolol inhibits the reaction [Streptozocin results in decreased expression of ADRB1 protein]

PMID:1312942, PMID:18703049, PMID:20590644
affects bindingISORGD:7312896480464CTDMetoprolol binds to ADRB1 protein

PMID:10372227
affects response to substanceISORGD:7312896480464CTDADRB1 gene affects the susceptibility to Metoprolol

ADRB1 gene polymorphism affects the susceptibility to Metoprolol

ADRB1 protein polymorphism affects the susceptibility to Metoprolol

PMID:12844134, PMID:15864115, PMID:19094446, PMID:21311897, PMID:22192668
decreases activityISORGD:7312896480464CTDMetoprolol results in decreased activity of ADRB1 protein

PMID:1389726
increases expressionISORGD:101066480464CTDMetoprolol results in increased expression of ADRB1 mRNA

PMID:20675662
multiple interactionsISORGD:7312896480464CTD[ADRB1 gene polymorphism co-treated with ADRA2C gene polymorphism] affects the susceptibility to Metoprolol

[Metoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP

ADRB1 gene polymorphism affects the susceptibility to [Dobutamine co-treated with Metoprolol]

Metoprolol binds to and results in decreased activity of ADRB1 protein

Metoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

Metoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]

PMID:11562432, PMID:14730417, PMID:15060759, PMID:17200720, PMID:17496726, PMID:20821015
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.