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RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: DOID:6000
Term: congestive heart failure
Definition: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Definition Source(s): MESH:D006333,
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IMP 5129119RGD  
 ISORGD:731289737774RGDDNA:polymorphism: :p.R389G (human)

 ISORGD:7312898554872ClinVarClinVar Annotator: match by term: Congestive heart failure and beta-blocker response, modifier of

PMID:10212248, PMID:12374873, PMID:16844790, PMID:17496726
 ISORGD:73128911554173CTDCTD Direct Evidence: marker/mechanism

PMID:7586371, PMID:12374873, PMID:14502278, PMID:15816327, PMID:21516734
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.