Kcnq2 (potassium voltage-gated channel subfamily Q member 2) - Rat Genome Database

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Gene: Kcnq2 (potassium voltage-gated channel subfamily Q member 2) Rattus norvegicus
Analyze
Symbol: Kcnq2 (Ensembl: Eef1a2)
Name: potassium voltage-gated channel subfamily Q member 2 (Ensembl:eukaryotic translation elongation factor 1 alpha 2)
RGD ID: 621504
Description: Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport. Located in axon initial segment and plasma membrane. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in benign neonatal seizures and developmental and epileptic encephalopathy 7. Orthologous to human KCNQ2 (potassium voltage-gated channel subfamily Q member 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: KQT-like 2; potassium channel subunit alpha KvLQT2; potassium channel, voltage-gated KQT-like subfamily Q, member 2; potassium voltage-gated channel subfamily KQT member 2; potassium voltage-gated channel, KQT-like subfamily, member 2; potassium voltage-gated channel, subfamily Q, member 2; voltage-gated potassium channel subunit Kv7.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,194,776 - 168,253,831 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,195,357 - 168,275,071 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,579,283 - 172,633,822 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,538,370 - 181,592,919 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,199,749 - 178,254,694 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,585,897 - 176,645,029 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,589,906 - 176,644,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,295,948 - 180,355,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,227,938 - 170,282,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,133,973 - 170,188,923 (-)NCBI
Celera3164,332,108 - 164,387,022 (+)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (ISO)
action potential initiation  (ISO)
apoptosome assembly  (ISO)
brain development  (ISO)
cellular response to calcium ion  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cognition  (ISO)
dentate gyrus development  (ISO)
determination of adult lifespan  (ISO)
endocytosis  (ISO)
establishment of cell polarity  (ISO)
excitatory chemical synaptic transmission  (ISO)
exocytosis  (ISO)
exploration behavior  (ISO)
gene expression  (ISO)
grooming behavior  (ISO)
hippocampal pyramidal neuron differentiation  (ISO)
hippocampus development  (ISO)
inhibitory chemical synaptic transmission  (ISO)
learning  (ISO)
membrane hyperpolarization  (ISO)
memory  (ISO)
mitochondrial depolarization  (ISO)
monoatomic ion transmembrane transport  (ISO)
motor behavior  (ISO)
nerve development  (ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (ISO)
neuron remodeling  (ISO)
neuronal action potential  (ISO)
potassium ion transmembrane transport  (IBA,IDA,IEA,ISO)
protein import into nucleus  (ISO)
protein transport  (ISO)
psychomotor behavior  (ISO)
regulation of action potential firing threshold  (ISO)
regulation of membrane potential  (ISO)
regulation of synaptic plasticity  (ISO)
response to auditory stimulus  (ISO)
response to mechanical stimulus  (ISO)
response to organic cyclic compound  (ISO)
response to temperature stimulus  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (ISO)
social behavior  (ISO)
sodium ion transmembrane transport  (ISO)
substantia propria of cornea development  (ISO)
transmission of nerve impulse  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Hoshi N, etal., Nat Neurosci 2003 Jun;6(6):564-71.
4. Cloning and functional expression of rKCNQ2 K(+) channel from rat brain. Jow F and Wang K, Brain Res Mol Brain Res. 2000 Sep 15;80(2):269-78.
5. Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. Kosenko A, etal., EMBO J. 2012 May 29;31(14):3147-56. doi: 10.1038/emboj.2012.156.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents. Pan Z, etal., J Physiol. 2001 Mar 1;531(Pt 2):347-58.
11. Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment. Rasmussen HB, etal., J Cell Sci. 2007 Mar 15;120(Pt 6):953-63. doi: 10.1242/jcs.03396. Epub 2007 Feb 20.
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Molecular correlates of the M-current in cultured rat hippocampal neurons. Shah MM, etal., J Physiol 2002 Oct 1;544(Pt 1):29-37.
15. The axon-dendrite targeting of Kv3 (Shaw) channels is determined by a targeting motif that associates with the T1 domain and ankyrin G. Xu M, etal., J Neurosci. 2007 Dec 19;27(51):14158-70. doi: 10.1523/JNEUROSCI.3675-07.2007.
16. The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels. Yus-Najera E, etal., J Biol Chem 2002 Aug 9;277(32):28545-53.
Additional References at PubMed
PMID:9836639   PMID:10788442   PMID:10854243   PMID:12223552   PMID:16154661   PMID:16263935   PMID:16525039   PMID:16527853   PMID:16735477   PMID:17322297   PMID:17437547   PMID:17442834  
PMID:18048450   PMID:18089837   PMID:18827480   PMID:20885443   PMID:21345591   PMID:21750731   PMID:21787867   PMID:22871113   PMID:23352759   PMID:23623937   PMID:24349250   PMID:24627475  
PMID:25077630   PMID:25735002   PMID:25796298   PMID:27445338   PMID:27450567   PMID:27564677   PMID:27905566   PMID:29133175   PMID:29212407   PMID:29488002   PMID:32067988   PMID:32739272  
PMID:34318654   PMID:34785595   PMID:35858950  


Genomics

Comparative Map Data
Kcnq2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,194,776 - 168,253,831 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,195,357 - 168,275,071 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,579,283 - 172,633,822 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,538,370 - 181,592,919 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,199,749 - 178,254,694 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,585,897 - 176,645,029 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,589,906 - 176,644,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,295,948 - 180,355,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,227,938 - 170,282,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,133,973 - 170,188,923 (-)NCBI
Celera3164,332,108 - 164,387,022 (+)NCBICelera
Cytogenetic Map3q43NCBI
KCNQ2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,400,208 - 63,472,655 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,400,208 - 63,472,677 (-)EnsemblGRCh38hg38GRCh38
GRCh372062,031,561 - 62,104,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,507,986 - 61,574,437 (-)NCBINCBI36Build 36hg18NCBI36
Build 342061,535,475 - 61,574,437NCBI
Celera2058,714,783 - 58,784,129 (-)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,763,581 - 58,832,303 (-)NCBIHuRef
CHM1_12061,938,421 - 62,005,028 (-)NCBICHM1_1
T2T-CHM13v2.02065,207,872 - 65,283,534 (-)NCBIT2T-CHM13v2.0
Kcnq2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,717,372 - 180,777,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,717,372 - 180,777,093 (-)EnsemblGRCm39 Ensembl
GRCm382181,075,579 - 181,135,580 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,075,579 - 181,135,300 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,810,284 - 180,869,930 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,004,987 - 181,064,633 (-)NCBIMGSCv36mm8
Celera2185,162,036 - 185,221,619 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.57NCBI
Kcnq2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528737,416 - 791,321 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955528737,416 - 792,885 (+)NCBIChiLan1.0ChiLan1.0
KCNQ2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12069,192,461 - 69,266,056 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl2061,325,365 - 61,395,266 (-)Ensemblpanpan1.1panPan2
KCNQ2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12447,060,527 - 47,089,077 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2447,060,245 - 47,089,711 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2446,239,964 - 46,285,184 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02448,009,941 - 48,055,221 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2448,013,499 - 48,211,383 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12447,025,196 - 47,070,380 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02447,149,830 - 47,195,058 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,905,637 - 47,933,777 (-)NCBIUU_Cfam_GSD_1.0
Kcnq2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,281,604 - 195,334,016 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,735,809 - 10,787,678 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651410,735,247 - 10,787,682 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,459,281 - 62,506,424 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,459,277 - 62,506,403 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNQ2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12739,965 - 803,575 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2761,952 - 802,999 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605048,302,539 - 48,404,899 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnq2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,091,119 - 29,143,589 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474129,089,894 - 29,143,681 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnq2
263 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1707
Count of miRNA genes:256
Interacting mature miRNAs:317
Transcripts:ENSRNOT00000045508, ENSRNOT00000049961, ENSRNOT00000051170
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
UniSTS:495992  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,232,144 - 168,232,567 (+)MAPPERmRatBN7.2
Rnor_6.03176,623,361 - 176,623,783NCBIRnor6.0
Rnor_5.03180,333,393 - 180,333,815UniSTSRnor5.0
RGSC_v3.43170,261,294 - 170,261,716UniSTSRGSC3.4
Celera3164,353,265 - 164,353,687UniSTS
Cytogenetic Map3q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 68
Low 1 3 6 17
Below cutoff 2 13 22 11 17 11 7 8 29 21 11 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF087453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000016947   ⟹   ENSRNOP00000016947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,199,994 - 168,275,071 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000049961   ⟹   ENSRNOP00000040830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,198,787 - 168,253,740 (-)Ensembl
Rnor_6.0 Ensembl3176,589,906 - 176,644,951 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094525   ⟹   ENSRNOP00000094215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,195,357 - 168,253,740 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102525   ⟹   ENSRNOP00000083195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,198,787 - 168,253,740 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105837   ⟹   ENSRNOP00000094928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,198,787 - 168,253,740 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109229   ⟹   ENSRNOP00000094730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,195,371 - 168,253,740 (-)Ensembl
RefSeq Acc Id: NM_133322   ⟹   NP_579856
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,198,787 - 168,253,740 (-)NCBI
Rnor_6.03176,589,906 - 176,644,951 (-)NCBI
Rnor_5.03180,295,948 - 180,355,064 (-)NCBI
RGSC_v3.43170,227,938 - 170,282,887 (-)RGD
Celera3164,332,108 - 164,387,022 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235721   ⟹   XP_006235783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,194,776 - 168,253,625 (-)NCBI
Rnor_6.03176,585,897 - 176,645,028 (-)NCBI
Rnor_5.03180,295,948 - 180,355,064 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235725   ⟹   XP_006235787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,194,776 - 168,253,625 (-)NCBI
Rnor_6.03176,585,897 - 176,645,028 (-)NCBI
Rnor_5.03180,295,948 - 180,355,064 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235727   ⟹   XP_006235789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,200,271 - 168,253,625 (-)NCBI
Rnor_6.03176,585,897 - 176,645,028 (-)NCBI
Rnor_5.03180,295,948 - 180,355,064 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235729   ⟹   XP_006235791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,200,271 - 168,253,625 (-)NCBI
Rnor_6.03176,585,897 - 176,645,028 (-)NCBI
Rnor_5.03180,295,948 - 180,355,064 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762462   ⟹   XP_008760684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,200,747 - 168,253,625 (-)NCBI
Rnor_6.03176,591,915 - 176,645,029 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591443   ⟹   XP_017446932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,200,271 - 168,253,625 (-)NCBI
Rnor_6.03176,585,897 - 176,645,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591445   ⟹   XP_017446934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,194,776 - 168,253,625 (-)NCBI
Rnor_6.03176,585,897 - 176,645,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591446   ⟹   XP_017446935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,200,271 - 168,253,625 (-)NCBI
Rnor_6.03176,585,897 - 176,645,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591447   ⟹   XP_017446936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,200,271 - 168,253,625 (-)NCBI
Rnor_6.03176,585,897 - 176,645,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104177   ⟹   XP_038960105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,194,776 - 168,253,831 (-)NCBI
RefSeq Acc Id: XM_039104178   ⟹   XP_038960106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,194,776 - 168,253,625 (-)NCBI
RefSeq Acc Id: XM_039104180   ⟹   XP_038960108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,194,776 - 168,253,625 (-)NCBI
RefSeq Acc Id: XM_039104181   ⟹   XP_038960109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,194,776 - 168,253,625 (-)NCBI
RefSeq Acc Id: XM_039104182   ⟹   XP_038960110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,194,776 - 168,253,625 (-)NCBI
RefSeq Acc Id: XM_039104183   ⟹   XP_038960111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,194,776 - 168,253,625 (-)NCBI
RefSeq Acc Id: XM_039104184   ⟹   XP_038960112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,194,776 - 168,253,625 (-)NCBI
RefSeq Acc Id: XM_039104185   ⟹   XP_038960113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,194,776 - 168,253,625 (-)NCBI
RefSeq Acc Id: XM_039104186   ⟹   XP_038960114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,194,776 - 168,253,625 (-)NCBI
RefSeq Acc Id: XR_005501759
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,206,765 - 168,253,625 (-)NCBI
RefSeq Acc Id: XR_005501760
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,206,765 - 168,253,625 (-)NCBI
RefSeq Acc Id: XR_005501761
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,206,765 - 168,253,625 (-)NCBI
RefSeq Acc Id: XR_005501762
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,207,685 - 168,253,625 (-)NCBI
Protein Sequences
Protein RefSeqs NP_579856 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235783 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235787 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235789 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235791 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760684 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446932 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446934 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446935 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446936 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960105 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960106 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960108 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960109 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960110 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960111 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960112 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960113 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960114 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC36722 (Get FASTA)   NCBI Sequence Viewer  
  EDL88759 (Get FASTA)   NCBI Sequence Viewer  
  EDL88760 (Get FASTA)   NCBI Sequence Viewer  
  EDL88761 (Get FASTA)   NCBI Sequence Viewer  
  EDL88762 (Get FASTA)   NCBI Sequence Viewer  
  EDL88763 (Get FASTA)   NCBI Sequence Viewer  
  EDL88764 (Get FASTA)   NCBI Sequence Viewer  
  EDL88765 (Get FASTA)   NCBI Sequence Viewer  
  EDL88766 (Get FASTA)   NCBI Sequence Viewer  
  EDL88767 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040830
  ENSRNOP00000040830.3
  ENSRNOP00000083195
  ENSRNOP00000083195.1
  ENSRNOP00000094215
  ENSRNOP00000094215.1
  ENSRNOP00000094730
  ENSRNOP00000094730.1
  ENSRNOP00000094928.1
GenBank Protein O88943 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_579856   ⟸   NM_133322
- UniProtKB: O88943 (UniProtKB/Swiss-Prot),   F1M6X3 (UniProtKB/TrEMBL),   A6KM54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235787   ⟸   XM_006235725
- Peptide Label: isoform X11
- UniProtKB: O88943 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006235783   ⟸   XM_006235721
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AIP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235791   ⟸   XM_006235729
- Peptide Label: isoform X16
- UniProtKB: O88943 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006235789   ⟸   XM_006235727
- Peptide Label: isoform X13
- UniProtKB: A0A8I5ZWG8 (UniProtKB/TrEMBL),   A0A8I6AIP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760684   ⟸   XM_008762462
- Peptide Label: isoform X18
- UniProtKB: A0A8I6B1F5 (UniProtKB/TrEMBL),   A6KM53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446934   ⟸   XM_017591445
- Peptide Label: isoform X14
- UniProtKB: O88943 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017446936   ⟸   XM_017591447
- Peptide Label: isoform X17
- UniProtKB: O88943 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017446935   ⟸   XM_017591446
- Peptide Label: isoform X15
- UniProtKB: O88943 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017446932   ⟸   XM_017591443
- Peptide Label: isoform X10
- UniProtKB: O88943 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000040830   ⟸   ENSRNOT00000049961
RefSeq Acc Id: XP_038960105   ⟸   XM_039104177
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AIP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960113   ⟸   XM_039104185
- Peptide Label: isoform X9
- UniProtKB: O88943 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038960114   ⟸   XM_039104186
- Peptide Label: isoform X12
- UniProtKB: O88943 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038960110   ⟸   XM_039104182
- Peptide Label: isoform X5
- UniProtKB: O88943 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038960108   ⟸   XM_039104180
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AIP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960111   ⟸   XM_039104183
- Peptide Label: isoform X6
- UniProtKB: O88943 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038960109   ⟸   XM_039104181
- Peptide Label: isoform X4
- UniProtKB: O88943 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038960106   ⟸   XM_039104178
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AIP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960112   ⟸   XM_039104184
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AIP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000094215   ⟸   ENSRNOT00000094525
RefSeq Acc Id: ENSRNOP00000094730   ⟸   ENSRNOT00000109229
RefSeq Acc Id: ENSRNOP00000016947   ⟸   ENSRNOT00000016947
RefSeq Acc Id: ENSRNOP00000083195   ⟸   ENSRNOT00000102525
RefSeq Acc Id: ENSRNOP00000094928   ⟸   ENSRNOT00000105837
Protein Domains
Ion transport   Potassium channel voltage dependent KCNQ C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88943-F1-model_v2 AlphaFold O88943 1-852 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621504 AgrOrtholog
BioCyc Gene G2FUF-46305 BioCyc
Ensembl Genes ENSRNOG00000011624 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049961 ENTREZGENE
  ENSRNOT00000049961.5 UniProtKB/TrEMBL
  ENSRNOT00000094525 ENTREZGENE
  ENSRNOT00000094525.1 UniProtKB/TrEMBL
  ENSRNOT00000102525 ENTREZGENE
  ENSRNOT00000102525.1 UniProtKB/TrEMBL
  ENSRNOT00000105837.1 UniProtKB/TrEMBL
  ENSRNOT00000109229 ENTREZGENE
  ENSRNOT00000109229.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.1910 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin-G_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170848 UniProtKB/Swiss-Prot
NCBI Gene 170848 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQ2_u3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQ_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQC3-Ank-G_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnq2 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQ2CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011624 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZWG8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIP3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B1F5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKM5_RAT UniProtKB/TrEMBL
  A6KM51_RAT UniProtKB/TrEMBL
  A6KM52_RAT UniProtKB/TrEMBL
  A6KM53 ENTREZGENE, UniProtKB/TrEMBL
  A6KM54 ENTREZGENE, UniProtKB/TrEMBL
  A6KM55_RAT UniProtKB/TrEMBL
  A6KM56_RAT UniProtKB/TrEMBL
  A6KM57_RAT UniProtKB/TrEMBL
  A6KM58_RAT UniProtKB/TrEMBL
  A6KM59_RAT UniProtKB/TrEMBL
  F1M6X3 ENTREZGENE, UniProtKB/TrEMBL
  KCNQ2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnq2  potassium voltage-gated channel subfamily Q member 2  Kcnq2  potassium channel, voltage-gated KQT-like subfamily Q, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnq2  potassium channel, voltage-gated KQT-like subfamily Q, member 2  Kcnq2  potassium voltage-gated channel, KQT-like subfamily, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Kcnq2  potassium voltage-gated channel, KQT-like subfamily, member 2  Kcnq2  potassium voltage-gated channel, subfamily Q, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Kcnq2  potassium voltage-gated channel, subfamily Q, member 2    potassium voltage-gated channel, KQT-like subfamily, member 2  Name updated 1299863 APPROVED
2002-08-07 Kcnq2  potassium voltage-gated channel, KQT-like subfamily, member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the antrum of the rat stomach, brain, adrenal gland, thymus, retina, and skeletal muscle 625508
gene_process contributes to M-like channels in neurons 625508
gene_process may function with KCNQ3 and KCNQ5 subunits to produce M-channel currents in neuronal cells 727441
gene_product 372 bp 625508