RGD Reference Report - A-kinase anchoring proteins: from protein complexes to physiology and disease. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

A-kinase anchoring proteins: from protein complexes to physiology and disease.

Authors: Carnegie, GK  Means, CK  Scott, JD 
Citation: Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
RGD ID: 2312477
Pubmed: PMID:19319965   (View Abstract at PubMed)
PMCID: PMC2682206   (View Article at PubMed Central)
DOI: DOI:10.1002/iub.168   (Journal Full-text)

Protein scaffold complexes are a key mechanism by which a common signaling pathway can serve many different functions. Sequestering a signaling enzyme to a specific subcellular environment not only ensures that the enzyme is near its relevant targets, but also segregates this activity to prevent indiscriminate phosphorylation of other substrates. One family of diverse, well-studied scaffolding proteins are the A-kinase anchoring proteins (AKAPs). These anchoring proteins form multi-protein complexes that integrate cAMP signaling with other pathways and signaling events. In this review, we focus on recent advances in the elucidation of AKAP function.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AKAP1Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
AKAP10Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
AKAP11Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
AKAP12Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
AKAP13Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
AKAP14Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
AKAP3Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
AKAP4Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
AKAP5Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
AKAP6Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
AKAP7Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
AKAP8Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
AKAP9Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
Akap1Ratprotein kinase A (PKA) signaling pathway   ISOAKAP1 (Homo sapiens) RGD 
Akap1Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP1 (Homo sapiens) RGD 
Akap10Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP10 (Homo sapiens) RGD 
Akap10Ratprotein kinase A (PKA) signaling pathway   ISOAKAP10 (Homo sapiens) RGD 
Akap11Ratprotein kinase A (PKA) signaling pathway   ISOAKAP11 (Homo sapiens) RGD 
Akap11Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP11 (Homo sapiens) RGD 
Akap12Ratprotein kinase A (PKA) signaling pathway   ISOAKAP12 (Homo sapiens) RGD 
Akap12Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP12 (Homo sapiens) RGD 
Akap13Ratprotein kinase A (PKA) signaling pathway   ISOAKAP13 (Homo sapiens) RGD 
Akap13Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP13 (Homo sapiens) RGD 
Akap14Ratprotein kinase A (PKA) signaling pathway   ISOAKAP14 (Homo sapiens) RGD 
Akap14Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP14 (Homo sapiens) RGD 
Akap3Ratprotein kinase A (PKA) signaling pathway   ISOAKAP3 (Homo sapiens) RGD 
Akap3Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP3 (Homo sapiens) RGD 
Akap4Ratprotein kinase A (PKA) signaling pathway   ISOAKAP4 (Homo sapiens) RGD 
Akap4Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP4 (Homo sapiens) RGD 
Akap5Ratprotein kinase A (PKA) signaling pathway   ISOAKAP5 (Homo sapiens) RGD 
Akap5Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP5 (Homo sapiens) RGD 
Akap6Ratprotein kinase A (PKA) signaling pathway   ISOAKAP6 (Homo sapiens) RGD 
Akap6Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP6 (Homo sapiens) RGD 
Akap7Ratprotein kinase A (PKA) signaling pathway   ISOAKAP7 (Homo sapiens) RGD 
Akap7Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP7 (Homo sapiens) RGD 
Akap8Ratprotein kinase A (PKA) signaling pathway   ISOAKAP8 (Homo sapiens) RGD 
Akap8Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP8 (Homo sapiens) RGD 
Akap9Ratprotein kinase A (PKA) signaling pathway   ISOAKAP9 (Homo sapiens) RGD 
Akap9Mouseprotein kinase A (PKA) signaling pathway   ISOAKAP9 (Homo sapiens) RGD 
PALM2AKAP2Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
PakapRatprotein kinase A (PKA) signaling pathway   ISOAKAP2 (Homo sapiens) RGD 
PakapMouseprotein kinase A (PKA) signaling pathway   ISOAKAP2 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Akap1  (A-kinase anchoring protein 1)
Akap10  (A-kinase anchoring protein 10)
Akap11  (A-kinase anchoring protein 11)
Akap12  (A-kinase anchoring protein 12)
Akap13  (A-kinase anchoring protein 13)
Akap14  (A-kinase anchoring protein 14)
Akap3  (A-kinase anchoring protein 3)
Akap4  (A-kinase anchoring protein 4)
Akap5  (A-kinase anchoring protein 5)
Akap6  (A-kinase anchoring protein 6)
Akap7  (A-kinase anchoring protein 7)
Akap8  (A-kinase anchoring protein 8)
Akap9  (A-kinase anchoring protein 9)
Pakap  (paralemmin A kinase anchor protein)

Genes (Mus musculus)
Akap1  (A kinase anchor protein 1)
Akap10  (A kinase anchor protein 10)
Akap11  (A kinase anchor protein 11)
Akap12  (A kinase anchor protein 12)
Akap13  (A kinase anchor protein 13)
Akap14  (A kinase anchor protein 14)
Akap3  (A kinase anchor protein 3)
Akap4  (A kinase anchor protein 4)
Akap5  (A kinase anchor protein 5)
Akap6  (A kinase anchor protein 6)
Akap7  (A kinase anchor protein 7)
Akap8  (A kinase anchor protein 8)
Akap9  (A kinase anchor protein 9)
Pakap  (paralemmin A kinase anchor protein)

Genes (Homo sapiens)
AKAP1  (A-kinase anchoring protein 1)
AKAP10  (A-kinase anchoring protein 10)
AKAP11  (A-kinase anchoring protein 11)
AKAP12  (A-kinase anchoring protein 12)
AKAP13  (A-kinase anchoring protein 13)
AKAP14  (A-kinase anchoring protein 14)
AKAP3  (A-kinase anchoring protein 3)
AKAP4  (A-kinase anchoring protein 4)
AKAP5  (A-kinase anchoring protein 5)
AKAP6  (A-kinase anchoring protein 6)
AKAP7  (A-kinase anchoring protein 7)
AKAP8  (A-kinase anchoring protein 8)
AKAP9  (A-kinase anchoring protein 9)
PALM2AKAP2  (PALM2 and AKAP2 fusion)


Additional Information