Cdh2 (cadherin 2) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cdh2 (cadherin 2) Rattus norvegicus
Symbol: Cdh2
Name: cadherin 2
RGD ID: 69280
Description: Enables beta-catenin binding activity; nitric-oxide synthase binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; regulation of glutamatergic synaptic transmission; and regulation of myelination. Located in several cellular components, including T-tubule; fascia adherens; and synaptic membrane. Part of protein-containing complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in agenesis of corpus callosum, cardiac, ocular, and genital syndrome; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 14. Orthologous to human CDH2 (cadherin 2); PARTICIPATES IN cadherin mediated signaling pathway; fibroblast growth factor signaling pathway; N-cadherin signaling pathway; INTERACTS WITH (+)-pilocarpine; 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); cadherin-2; N-cadherin; neural cadherin
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2187,776,704 - 7,990,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl187,776,704 - 7,990,167 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,020,068 - 8,240,669 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0188,807,745 - 9,028,345 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,079,330 - 8,299,941 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,146,971 - 8,366,037 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,146,971 - 8,360,684 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0187,997,533 - 8,218,018 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4188,048,920 - 8,267,974 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1188,048,919 - 8,268,462 (-)NCBI
Celera187,938,006 - 8,155,134 (-)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-Tetrandrine  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
9-cis-retinoic acid  (ISO)
[6]-Shogaol  (ISO)
acadesine  (ISO)
acrolein  (EXP)
acrylonitrile  (ISO)
aflatoxin B1  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
ametryn  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
antimycin A  (ISO)
antroquinonol  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
azithromycin  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcidiol  (EXP)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chloroquine  (EXP)
chrysin  (ISO)
cisatracurium  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
Destruxin B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
dimethyl sulfoxide  (ISO)
dimethylselenide  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl trans-caffeate  (ISO)
fenbendazole  (ISO)
fenpyroximate  (ISO)
fisetin  (ISO)
flubendazole  (ISO)
fludioxonil  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
genistein  (ISO)
Ginkgoic acid  (ISO)
glafenine  (EXP)
Goe 6976  (EXP)
gossypol  (EXP)
hydrogen peroxide  (ISO)
hydroxyflutamide  (ISO)
indirubin  (ISO)
isoorientin  (ISO)
isoprenaline  (ISO)
isoprene  (ISO)
jaspamide  (ISO)
L-ascorbic acid  (EXP)
lapatinib  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
loliolide  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mebendazole  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
methapyrilene  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
morusin  (ISO)
N(6),N(6)-dimethyladenine  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrogen mustard  (ISO)
Nonylphenol  (EXP,ISO)
novobiocin  (ISO)
Ophiopogonin D  (ISO)
oridonin  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-cresol  (EXP)
p-tert-Amylphenol  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
patulin  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
phenol red  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
plerixafor  (ISO)
potassium iodide  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
ridaforolimus  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
SB 290157  (ISO)
SB 431542  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
solasodine  (ISO)
Soman  (EXP)
sorafenib  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
taraxasterol  (ISO)
tauroursodeoxycholic acid  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
ubiquinone-0  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin D  (EXP)
vitamin E  (EXP)
wortmannin  (ISO)
XAV939  (ISO)
zardaverine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction organization  (IBA)
blood vessel morphogenesis  (IBA,IEA,ISO)
brain development  (IBA)
brain morphogenesis  (IEA,ISO)
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  (IBA,IEA,IMP,ISO)
cell adhesion  (ISO)
cell migration  (ISO)
cell morphogenesis  (IBA)
cell-cell adhesion  (IDA,ISO)
cell-cell adhesion mediated by cadherin  (IBA,IEA,ISO,ISS)
cell-cell junction assembly  (IBA,IEA,ISO,ISS)
cerebral cortex development  (IEA,ISO)
glial cell differentiation  (ISO,ISS)
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  (IEA,ISO)
homeostasis of number of cells  (IEA,ISO)
homophilic cell adhesion via plasma membrane adhesion molecules  (IBA,IEA,ISO)
mesenchymal cell migration  (IEA,ISO)
modulation of chemical synaptic transmission  (EXP,IDA)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
neural crest cell development  (IEA,ISO,ISS)
neuroepithelial cell differentiation  (IEA,ISO)
neuroligin clustering involved in postsynaptic membrane assembly  (IEA,ISO)
neuronal stem cell population maintenance  (IEA,ISO,ISS)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of synaptic vesicle clustering  (IEA,ISO)
protein localization to plasma membrane  (IEA,ISO)
radial glial cell differentiation  (IEA,ISO)
regulation of axonogenesis  (IBA,IMP)
regulation of myelination  (IMP)
regulation of oligodendrocyte progenitor proliferation  (IEA,ISO)
regulation of postsynaptic density protein 95 clustering  (IEA,ISO)
regulation of protein localization  (IMP)
regulation of Rho protein signal transduction  (IMP)
regulation of synaptic transmission, glutamatergic  (IBA,IMP)
striated muscle cell differentiation  (IEA,ISO)
synapse assembly  (IBA,IMP)
synaptic membrane adhesion  (IC)
synaptic vesicle clustering  (IEA,ISO,ISS)
telencephalon development  (ISO)
type B pancreatic cell development  (IEA,ISO,ISS)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Bakkaloglu B, etal., Am J Hum Genet. 2008 Jan;82(1):165-73. doi: 10.1016/j.ajhg.2007.09.017.
2. Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites, and required for potentiation. Bozdagi O, etal., Neuron. 2000 Oct;28(1):245-59.
3. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Chen YM, etal., Biol Reprod. 2003 Aug;69(2):656-72. Epub 2003 Apr 16.
4. Rat testicular N-cadherin: its complementary deoxyribonucleic acid cloning and regulation. Chung SS, etal., Endocrinology 1998 Apr;139(4):1853-62.
5. [Dynamic assembly of intercalated disc during postnatal development in the rat myocardium]. Dou JP, etal., Sheng Li Xue Bao. 2014 Oct 25;66(5):569-74.
6. Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS. Fasen K, etal., J Neuropathol Exp Neurol 2002 Oct;61(10):903-13.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Gorski JA, etal., Mol Biol Cell. 2005 Aug;16(8):3574-90. Epub 2005 Jun 1.
10. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Hermiston ML and Gordon JI, Science 1995 Nov 17;270(5239):1203-7.
11. N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes. Hertig CM, etal., J Cell Sci. 1996 Jan;109 ( Pt 1):11-20.
12. Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. Johnson KJ, etal., Endocrinology 2000 Feb;141(2):675-83.
13. N-cadherin upregulation and function in response of smooth muscle cells to arterial injury. Jones M, etal., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):1972-7.
14. Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase. Kwon YT, etal., Curr Biol. 2000 Apr 6;10(7):363-72.
15. Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis? Lee NP, etal., Biol Reprod. 2003 Feb;68(2):489-508.
16. Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study. Lee NP, etal., Biol Reprod. 2005 Sep;73(3):458-71. Epub 2005 Apr 27.
17. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
18. N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes. Matsuda T, etal., J Mol Cell Cardiol. 2006 Apr;40(4):495-502. Epub 2006 Mar 2.
19. Identification of Cadherin 2 (CDH2) Mutations in Arrhythmogenic Right Ventricular Cardiomyopathy. Mayosi BM, etal., Circ Cardiovasc Genet. 2017 Apr;10(2). pii: CIRCGENETICS.116.001605. doi: 10.1161/CIRCGENETICS.116.001605.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Mohler PJ, etal., Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17533-8. Epub 2004 Dec 3.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. N-cadherin regulates ingrowth and laminar targeting of thalamocortical axons. Poskanzer K, etal., J Neurosci 2003 Mar 15;23(6):2294-305.
26. Endothelial-to-mesenchymal transition in pulmonary hypertension. Ranchoux B, etal., Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). Sato M, etal., J Biol Chem. 2009 Nov 6;284(45):31431-40. doi: 10.1074/jbc.M109.014068. Epub 2009 Sep 1.
31. N-cadherin is involved in axon-oligodendrocyte contact and myelination. Schnadelbach O, etal., Mol Cell Neurosci. 2001 Jun;17(6):1084-93.
32. Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure. Shan W, etal., J Neurosci Res 2002 Aug 1;69(3):292-304.
33. Comparative expression patterns of T-, N-, E-cadherins, beta-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development: implications for the nature of Kolliker's organ. Simonneau L, etal., J Comp Neurol 2003 Apr 28;459(2):113-26.
34. A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation. Tang L, etal., Neuron. 1998 Jun;20(6):1165-75.
35. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
36. Whole exome sequencing with genomic triangulation implicates CDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy. Turkowski KL, etal., Congenit Heart Dis. 2017 Mar;12(2):226-235. doi: 10.1111/chd.12462. Epub 2017 Mar 21.
37. Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. Xia W, etal., J Biol Chem. 2006 Jun 16;281(24):16799-813. Epub 2006 Apr 13.
38. AMD3100 inhibits epithelial-mesenchymal transition, cell invasion, and metastasis in the liver and the lung through blocking the SDF-1α/CXCR4 signaling pathway in prostate cancer. Zhu WB, etal., J Cell Physiol. 2019 Jul;234(7):11746-11759. doi: 10.1002/jcp.27831. Epub 2018 Dec 7.
Additional References at PubMed
PMID:7650039   PMID:8270638   PMID:9531566   PMID:9655503   PMID:11732910   PMID:12052883   PMID:12203715   PMID:12695331   PMID:12738802   PMID:14561752   PMID:14622577   PMID:14657280  
PMID:15383621   PMID:15389538   PMID:15569714   PMID:15691707   PMID:15741167   PMID:15750591   PMID:15809310   PMID:16580782   PMID:16831887   PMID:16886205   PMID:16892058   PMID:16955247  
PMID:16973135   PMID:17028923   PMID:17188238   PMID:17884088   PMID:17959753   PMID:17988630   PMID:18064706   PMID:18067145   PMID:18239929   PMID:18617695   PMID:19075000   PMID:19101069  
PMID:19377287   PMID:19546590   PMID:19830702   PMID:20160094   PMID:20190754   PMID:20333303   PMID:20457910   PMID:20534458   PMID:20623533   PMID:20638445   PMID:20668183   PMID:20848607  
PMID:20881055   PMID:21056983   PMID:21250828   PMID:21257918   PMID:21296051   PMID:21300292   PMID:21414924   PMID:21423176   PMID:21520058   PMID:21572446   PMID:21720156   PMID:21720765  
PMID:21947081   PMID:22199283   PMID:22328515   PMID:22354041   PMID:22467863   PMID:22489706   PMID:22698587   PMID:22735489   PMID:22871113   PMID:23271561   PMID:23292232   PMID:23376485  
PMID:23392350   PMID:24046456   PMID:24223993   PMID:24338362   PMID:24412534   PMID:24891510   PMID:24952463   PMID:25100583   PMID:25232112   PMID:25512490   PMID:25724647   PMID:26187182  
PMID:26345922   PMID:26403541   PMID:26545901   PMID:27559042   PMID:27816814   PMID:28008617   PMID:28169360   PMID:28213972   PMID:28641114   PMID:29131030   PMID:29133434   PMID:29238079  
PMID:29257288   PMID:29768261  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2187,776,704 - 7,990,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl187,776,704 - 7,990,167 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,020,068 - 8,240,669 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0188,807,745 - 9,028,345 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,079,330 - 8,299,941 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,146,971 - 8,366,037 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,146,971 - 8,360,684 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0187,997,533 - 8,218,018 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4188,048,920 - 8,267,974 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1188,048,919 - 8,268,462 (-)NCBI
Celera187,938,006 - 8,155,134 (-)NCBICelera
Cytogenetic Map18p13NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381827,932,879 - 28,177,130 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1827,932,879 - 28,177,946 (-)EnsemblGRCh38hg38GRCh38
GRCh371825,530,930 - 25,757,094 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361823,784,933 - 24,011,189 (-)NCBINCBI36Build 36hg18NCBI36
Build 341823,784,933 - 24,011,189NCBI
Celera1822,342,317 - 22,568,868 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1822,383,072 - 22,579,896 (-)NCBIHuRef
CHM1_11825,458,398 - 25,684,881 (-)NCBICHM1_1
T2T-CHM13v2.01828,127,759 - 28,372,130 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391816,721,934 - 16,942,303 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1816,721,934 - 16,942,303 (-)EnsemblGRCm39 Ensembl
GRCm381816,588,877 - 16,809,246 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1816,588,877 - 16,809,246 (-)EnsemblGRCm38mm10GRCm38
MGSCv371816,747,386 - 16,967,558 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361816,732,027 - 16,952,264 (-)NCBIMGSCv36mm8
Celera1817,099,283 - 17,328,154 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map1810.1NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540215,831,110 - 16,049,890 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540215,829,895 - 16,049,874 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11831,075,259 - 31,301,025 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01821,210,001 - 21,435,919 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11824,812,019 - 25,008,249 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1824,812,019 - 25,008,325 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1760,736,760 - 60,950,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl760,736,760 - 60,951,034 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha760,142,523 - 60,355,795 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0760,754,899 - 60,968,628 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl760,754,774 - 60,968,438 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1760,431,048 - 60,644,193 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0760,442,612 - 60,655,854 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0760,744,933 - 60,958,801 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494456,749,166 - 56,930,675 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365506,886,706 - 6,945,056 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365506,885,484 - 7,067,001 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl6112,396,721 - 112,628,432 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16112,396,713 - 112,629,073 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26105,317,507 - 105,518,900 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11852,426,381 - 52,652,986 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1852,426,077 - 52,654,828 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605027,147,394 - 27,374,174 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247704,334,202 - 4,545,470 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247704,333,643 - 4,540,817 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cdh2
1391 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:109
Interacting mature miRNAs:132
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18224947722066430Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18679125112205285Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18679125112205285Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18679125112205285Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18679125112205285Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18679125112205285Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,939,002 - 7,939,178 (+)MAPPERmRatBN7.2
Rnor_6.0188,309,243 - 8,309,418NCBIRnor6.0
Rnor_5.0188,161,224 - 8,161,399UniSTSRnor5.0
RGSC_v3.4188,211,177 - 8,211,405RGDRGSC3.4
RGSC_v3.4188,211,180 - 8,211,355UniSTSRGSC3.4
RGSC_v3.1188,211,180 - 8,211,355RGD
Celera188,099,385 - 8,099,560UniSTS
RH 3.4 Map1866.1RGD
RH 3.4 Map1866.1UniSTS
Cytogenetic Map18p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,866,120 - 7,866,271 (+)MAPPERmRatBN7.2
Rnor_6.0188,236,422 - 8,236,572NCBIRnor6.0
Rnor_5.0188,088,405 - 8,088,555UniSTSRnor5.0
RGSC_v3.4188,138,359 - 8,138,509UniSTSRGSC3.4
Celera188,026,453 - 8,026,603UniSTS
Cytogenetic Map18p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,776,887 - 7,777,044 (+)MAPPERmRatBN7.2
Rnor_6.0188,147,155 - 8,147,311NCBIRnor6.0
Rnor_5.0187,997,717 - 7,997,873UniSTSRnor5.0
RGSC_v3.4188,049,104 - 8,049,260UniSTSRGSC3.4
Cytogenetic Map18p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,777,618 - 7,777,813 (+)MAPPERmRatBN7.2
Rnor_6.0188,147,886 - 8,148,080NCBIRnor6.0
Rnor_5.0187,998,448 - 7,998,642UniSTSRnor5.0
RGSC_v3.4188,049,835 - 8,050,029UniSTSRGSC3.4
Celera187,938,903 - 7,939,097UniSTS
RH 3.4 Map1868.0UniSTS
Cytogenetic Map18p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,859,971 - 7,860,169 (+)MAPPERmRatBN7.2
Rnor_6.0188,230,273 - 8,230,470NCBIRnor6.0
Rnor_5.0188,082,256 - 8,082,453UniSTSRnor5.0
RGSC_v3.4188,132,210 - 8,132,407UniSTSRGSC3.4
Celera188,020,304 - 8,020,501UniSTS
RH 3.4 Map1882.31UniSTS
Cytogenetic Map18p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,932,939 - 7,933,165 (+)MAPPERmRatBN7.2
Rnor_6.0188,303,180 - 8,303,405NCBIRnor6.0
Rnor_5.0188,155,161 - 8,155,386UniSTSRnor5.0
RGSC_v3.4188,205,117 - 8,205,342UniSTSRGSC3.4
Celera188,093,321 - 8,093,546UniSTS
RH 3.4 Map1866.41UniSTS
Cytogenetic Map18p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,895,010 - 7,895,134 (+)MAPPERmRatBN7.2
Rnor_6.0188,265,309 - 8,265,435NCBIRnor6.0
Rnor_5.0188,117,292 - 8,117,418UniSTSRnor5.0
RGSC_v3.4188,167,246 - 8,167,372UniSTSRGSC3.4
Cytogenetic Map18p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,956,439 - 7,956,630 (+)MAPPERmRatBN7.2
Rnor_6.0188,326,678 - 8,326,868NCBIRnor6.0
Rnor_5.0188,178,659 - 8,178,849UniSTSRnor5.0
RGSC_v3.4188,228,615 - 8,228,805UniSTSRGSC3.4
Celera188,115,783 - 8,115,973UniSTS
RH 3.4 Map1868.0UniSTS
Cytogenetic Map18p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,810,266 - 7,810,521 (+)MAPPERmRatBN7.2
Rnor_6.0188,180,549 - 8,180,803NCBIRnor6.0
Rnor_5.0188,031,420 - 8,031,674UniSTSRnor5.0
RGSC_v3.4188,082,486 - 8,082,740UniSTSRGSC3.4
Celera187,971,154 - 7,971,408UniSTS
Cytogenetic Map18p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,776,763 - 7,777,432 (+)MAPPERmRatBN7.2
Rnor_6.0188,147,031 - 8,147,699NCBIRnor6.0
Rnor_5.0187,997,593 - 7,998,261UniSTSRnor5.0
RGSC_v3.4188,048,980 - 8,049,648UniSTSRGSC3.4
Celera187,938,066 - 7,938,716UniSTS
Cytogenetic Map18p13UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 43 44 41 2 41 74 35 31
Low 3 13 17 8 10 10 11 8
Below cutoff 1


RefSeq Acc Id: ENSRNOT00000021170   ⟹   ENSRNOP00000021170
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl187,776,704 - 7,990,167 (-)Ensembl
Rnor_6.0 Ensembl188,146,971 - 8,360,684 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108729   ⟹   ENSRNOP00000084692
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl187,776,704 - 7,893,134 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115561   ⟹   ENSRNOP00000083478
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl187,776,704 - 7,857,840 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118601   ⟹   ENSRNOP00000091203
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl187,776,704 - 7,957,490 (-)Ensembl
RefSeq Acc Id: NM_031333   ⟹   NP_112623
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2187,776,704 - 7,990,934 (-)NCBI
Rnor_6.0188,146,971 - 8,366,037 (-)NCBI
Rnor_5.0187,997,533 - 8,218,018 (-)NCBI
RGSC_v3.4188,048,920 - 8,267,974 (-)RGD
Celera187,938,006 - 8,155,134 (-)RGD
RefSeq Acc Id: NP_112623   ⟸   NM_031333
- Peptide Label: precursor
- UniProtKB: Q9Z1Y3 (UniProtKB/Swiss-Prot),   Q9R0T5 (UniProtKB/Swiss-Prot),   G3V803 (UniProtKB/TrEMBL),   A6J2E5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021170   ⟸   ENSRNOT00000021170
RefSeq Acc Id: ENSRNOP00000083478   ⟸   ENSRNOT00000115561
RefSeq Acc Id: ENSRNOP00000091203   ⟸   ENSRNOT00000118601
RefSeq Acc Id: ENSRNOP00000084692   ⟸   ENSRNOT00000108729
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1Y3-F1-model_v2 AlphaFold Q9Z1Y3 1-906 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700649
Promoter ID:EPDNEW_R11173
Type:multiple initiation site
Description:cadherin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0188,360,413 - 8,360,473EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69280 AgrOrtholog
BioCyc Gene G2FUF-8263 BioCyc
Ensembl Genes ENSRNOG00000015602 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021170 ENTREZGENE
  ENSRNOT00000021170.7 UniProtKB/TrEMBL
  ENSRNOT00000108729.1 UniProtKB/TrEMBL
  ENSRNOT00000115561.1 UniProtKB/TrEMBL
  ENSRNOT00000118601.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_cytoplasmic-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_pro_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catenin_binding_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83501 UniProtKB/Swiss-Prot
PANTHER PTHR24027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24027:SF79 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_pro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdh2 PhenoGen
  DESMOCOLLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015602 RatGTEx
SMART Cadherin_pro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218644
UniProt A0A8I6A028_RAT UniProtKB/TrEMBL
  A0A8I6A049_RAT UniProtKB/TrEMBL
  CADH2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9R0T5 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cdh2  cadherin 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease increased expression occurs after balloon catheter injury of the carotid artery 68759
gene_process may be involved in facilitating germ cell migration during spermatogenesis 68761