Kcnma1 (potassium calcium-activated channel subfamily M alpha 1) - Rat Genome Database

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Gene: Kcnma1 (potassium calcium-activated channel subfamily M alpha 1) Rattus norvegicus
Analyze
Symbol: Kcnma1
Name: potassium calcium-activated channel subfamily M alpha 1
RGD ID: 620715
Description: Exhibits identical protein binding activity; large conductance calcium-activated potassium channel activity; and ligand-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including negative regulation of small intestine smooth muscle contraction; positive regulation of neuron apoptotic process; and response to estrogen. Localizes to several cellular components, including external side of plasma membrane; glutamatergic synapse; and integral component of presynaptic active zone membrane. Colocalizes with mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1); INTERACTS WITH (+)-pilocarpine; (+)-Pimaric acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BK channel; BKCa; BKCA alpha; calcium-activated potassium channel alpha subunit; calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel, subfamily M subunit alpha-1; cbv1; k(VCA)alpha; KCa1.1; Kcnma; KCNMA1b; KCNMA1c; LOC498438; maxi K channel; maxiK; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; similar to potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Slo; slo homolog; slo-alpha; slo1; slowpoke homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kcnma1_v1   Kcnma1_v2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.215302,078 - 1,001,198 (+)NCBI
Rnor_6.0 Ensembl15344,360 - 1,047,956 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.015344,204 - 1,048,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.015339,100 - 1,037,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415575,136 - 950,275 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.115322,288 - 950,273NCBI
Celera153,556,267 - 4,246,392 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-Pimaric acid  (EXP)
(R)-noradrenaline  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylcholine  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
caesium atom  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cisplatin  (ISO)
clothianidin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
endosulfan  (EXP,ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP)
genistein  (ISO)
glucose  (ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
Lasiocarpine  (ISO)
lithocholic acid  (EXP,ISO)
maneb  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
mifepristone  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
NS 1619  (ISO)
O-methyleugenol  (ISO)
paclitaxel  (ISO)
paraquat  (ISO)
Paxilline  (EXP)
PCB138  (ISO)
pentanal  (ISO)
pergolide  (EXP)
phloretin  (EXP)
piroxicam  (ISO)
potassium atom  (EXP,ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
pyridaben  (ISO)
rubidium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tetrachloromethane  (EXP)
tetraethylammonium  (ISO)
thallium  (ISO)
toluene  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
1. Avdonin V, etal., Biophys J. 2003 May;84(5):2969-80.
2. Berkefeld H, etal., Science. 2006 Oct 27;314(5799):615-20.
3. Burns LC, etal., Am J Med Genet B Neuropsychiatr Genet. 2011 Jun;156B(4):507-12. doi: 10.1002/ajmg.b.31194. Epub 2011 Apr 7.
4. Chen M, etal., Mol Neurobiol. 2013 Dec;48(3):794-807. doi: 10.1007/s12035-013-8467-x. Epub 2013 May 8.
5. Ding JP and Lingle CJ, Biophys J 2002 May;82(5):2448-65.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Gong LW, etal., Jpn J Physiol 2001 Dec;51(6):725-31.
8. Ha TS, etal., Biophys J. 2004 May;86(5):2871-82.
9. Ha TS, etal., Eur J Biochem 2000 Feb;267(3):910-8.
10. Hu H, etal., J Neurosci. 2001 Dec 15;21(24):9585-97.
11. Iozzi D, etal., Acta Physiol (Oxf). 2013 Aug;208(4):329-39. doi: 10.1111/apha.12083. Epub 2013 Mar 25.
12. Jing F, etal., J Pharm Pharmacol. 2013 Jun;65(6):847-54. doi: 10.1111/jphp.12041. Epub 2013 Feb 28.
13. Jo S, etal., J Neurochem. 2005 Sep;94(5):1212-24. Epub 2005 Jul 25.
14. Kanthesh BM, etal., Am J Physiol Cell Physiol. 2013 Nov 1;305(9):C972-80. doi: 10.1152/ajpcell.00165.2013. Epub 2013 Aug 28.
15. Kim H, etal., Proteomics. 2007 Aug;7(15):2591-602.
16. Lai GJ and McCobb DP, Endocrinology. 2006 Aug;147(8):3961-7. Epub 2006 May 4.
17. Lai GJ and McCobb DP, Proc Natl Acad Sci U S A 2002 May 28;99(11):7722-7.
18. Li M, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19096-101. doi: 10.1073/pnas.1002685107. Epub 2010 Oct 19.
19. Liu G, etal., EMBO J. 2004 Jun 2;23(11):2196-205. Epub 2004 May 13.
20. Marijic J, etal., Circ Res. 2001 Feb 2;88(2):210-6.
21. MGD data from the GO Consortium
22. Mi H, etal., Glia. 1999 Apr;26(2):166-75.
23. NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. OMIM Disease Annotation Pipeline
25. Park SM, etal., FEBS Lett. 2004 Jul 16;570(1-3):143-8.
26. RGD automated data pipeline
27. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. RGD automated import pipeline for gene-chemical interactions
29. Shanley LJ, etal., Nat Neurosci 2002 Apr;5(4):299-300.
30. Shi L, etal., Mech Ageing Dev. 2013 Sep;134(9):416-25. doi: 10.1016/j.mad.2013.09.001. Epub 2013 Sep 16.
31. Silva JM and Lewis DL, Pflugers Arch 2002 Mar;443(5-6):671-5.
32. Singh H, etal., Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10836-41. doi: 10.1073/pnas.1302028110. Epub 2013 Jun 10.
33. Wang Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Feb;34(2):188-92.
34. Williams SE, etal., Science. 2004 Dec 17;306(5704):2093-7. Epub 2004 Nov 4.
35. Xie J and McCobb DP, Science 1998 Apr 17;280(5362):443-6.
36. Zhu N, etal., FEBS Lett. 2005 Aug 29;579(21):4856-60.
Additional References at PubMed
PMID:7573516   PMID:7687074   PMID:7877450   PMID:7993625   PMID:9403560   PMID:10517674   PMID:10840032   PMID:11245614   PMID:11278440   PMID:11641143   PMID:11880513   PMID:12388065  
PMID:12388098   PMID:12454985   PMID:12547730   PMID:12949219   PMID:12952984   PMID:14523450   PMID:15049854   PMID:15184377   PMID:15194823   PMID:15328414   PMID:15703204   PMID:15827347  
PMID:15867178   PMID:16081418   PMID:16166559   PMID:16306267   PMID:16341213   PMID:16566008   PMID:16763026   PMID:16845385   PMID:16873365   PMID:16997278   PMID:17074442   PMID:17097837  
PMID:17122062   PMID:17135251   PMID:17150299   PMID:17166942   PMID:17259072   PMID:17303127   PMID:17468198   PMID:17701422   PMID:17706472   PMID:18079116   PMID:18180950   PMID:18250327  
PMID:18458941   PMID:18562499   PMID:18573811   PMID:18953570   PMID:19168436   PMID:19651031   PMID:19940072   PMID:20574420   PMID:20713546   PMID:20817829   PMID:20933547   PMID:20936291  
PMID:20938677   PMID:21079807   PMID:21158046   PMID:21186374   PMID:21325638   PMID:21900688   PMID:22052159   PMID:22131374   PMID:22322970   PMID:22350354   PMID:22555843   PMID:22570490  
PMID:22633934   PMID:22808126   PMID:22871113   PMID:22882938   PMID:23376485   PMID:23646921   PMID:23872879   PMID:23937098   PMID:24397812   PMID:24462688   PMID:24602615   PMID:24729485  
PMID:24836752   PMID:25139746   PMID:25192641   PMID:25371198   PMID:25481230   PMID:25494655   PMID:25661478   PMID:25864652   PMID:26277265   PMID:26755740   PMID:26791489   PMID:26823461  
PMID:27329042   PMID:28075010   PMID:28665272   PMID:28672269   PMID:29508439   PMID:29558628   PMID:30612588   PMID:30991005   PMID:31152168   PMID:32967457  


Genomics

Comparative Map Data
Kcnma1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.215302,078 - 1,001,198 (+)NCBI
Rnor_6.0 Ensembl15344,360 - 1,047,956 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.015344,204 - 1,048,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.015339,100 - 1,037,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415575,136 - 950,275 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.115322,288 - 950,273NCBI
Celera153,556,267 - 4,246,392 (-)NCBICelera
Cytogenetic Map15p16NCBI
KCNMA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1076,869,601 - 77,638,369 (-)EnsemblGRCh38hg38GRCh38
GRCh381076,869,602 - 77,637,969 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371078,629,360 - 79,397,566 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361078,299,366 - 79,067,583 (-)NCBINCBI36hg18NCBI36
Build 341078,314,640 - 79,067,583NCBI
Celera1071,914,113 - 72,684,182 (-)NCBI
Cytogenetic Map10q22.3NCBI
HuRef1072,624,294 - 73,391,824 (-)NCBIHuRef
CHM1_11078,911,952 - 79,680,009 (-)NCBICHM1_1
Kcnma1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391423,342,356 - 24,055,173 (-)NCBIGRCm39mm39
GRCm39 Ensembl1423,339,499 - 24,064,559 (-)Ensembl
GRCm381423,292,288 - 24,005,110 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1423,289,431 - 24,014,491 (-)EnsemblGRCm38mm10GRCm38
MGSCv371424,117,983 - 24,823,427 (-)NCBIGRCm37mm9NCBIm37
MGSCv361422,088,573 - 22,792,482 (-)NCBImm8
Celera1419,676,577 - 20,379,488 (-)NCBICelera
Cytogenetic Map14A3NCBI
Kcnma1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543714,749,914 - 15,454,028 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543714,749,808 - 15,457,274 (+)NCBIChiLan1.0ChiLan1.0
KCNMA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11076,053,915 - 76,820,639 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1076,062,047 - 76,820,644 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01073,391,297 - 74,158,488 (-)NCBIMhudiblu_PPA_v0panPan3
KCNMA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1426,844,250 - 27,338,271 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl426,844,250 - 27,555,776 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha426,970,672 - 27,681,029 (-)NCBI
ROS_Cfam_1.0427,145,564 - 27,857,706 (-)NCBI
UMICH_Zoey_3.1427,020,780 - 27,731,400 (-)NCBI
UNSW_CanFamBas_1.0427,220,327 - 27,931,096 (-)NCBI
UU_Cfam_GSD_1.0427,571,588 - 28,283,070 (-)NCBI
Kcnma1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721353,507,382 - 54,220,539 (+)NCBI
SpeTri2.0NW_0049365212,000,113 - 2,706,010 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNMA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1479,352,396 - 80,106,258 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11479,345,382 - 80,106,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21485,796,582 - 85,996,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21486,640,231 - 86,640,531 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21486,138,921 - 86,358,528 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNMA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1953,727,790 - 54,557,252 (+)NCBI
ChlSab1.1 Ensembl954,182,910 - 54,554,716 (+)Ensembl
Vero_WHO_p1.0NW_02366604814,223,140 - 14,987,512 (+)NCBI
Kcnma1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475410,152,635 - 10,885,239 (-)NCBI

Position Markers
D15Rat73  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215821,049 - 821,287 (+)MAPPER
Rnor_6.015873,565 - 873,802NCBIRnor6.0
Rnor_5.015862,384 - 862,621UniSTSRnor5.0
RGSC_v3.415766,501 - 766,738UniSTSRGSC3.4
RGSC_v3.415766,261 - 766,899RGDRGSC3.4
RGSC_v3.115766,502 - 766,738RGD
Celera153,729,257 - 3,729,494UniSTS
RH 3.4 Map1534.9RGD
RH 3.4 Map1534.9UniSTS
RH 2.0 Map150.0RGD
SHRSP x BN Map153.9298RGD
FHH x ACI Map150.04RGD
Cytogenetic Map15p16UniSTS
D15Rat108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215616,969 - 617,127 (+)MAPPER
Rnor_6.015668,009 - 668,166NCBIRnor6.0
Rnor_5.015658,019 - 658,176UniSTSRnor5.0
RGSC_v3.415557,527 - 557,682RGDRGSC3.4
RGSC_v3.415557,528 - 557,685UniSTSRGSC3.4
RGSC_v3.115557,527 - 557,682RGD
Celera153,933,166 - 3,933,327UniSTS
FHH x ACI Map150.0RGD
FHH x ACI Map150.0UniSTS
Cytogenetic Map15p16UniSTS
D15Rat135  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215568,533 - 568,738 (+)MAPPER
Rnor_6.015613,195 - 613,399NCBIRnor6.0
Rnor_5.015603,180 - 603,384UniSTSRnor5.0
RGSC_v3.415506,685 - 506,890RGDRGSC3.4
RGSC_v3.415506,686 - 506,890UniSTSRGSC3.4
RGSC_v3.115506,487 - 507,058RGD
Celera153,981,511 - 3,981,715UniSTS
RH 2.0 Map150.0RGD
SHRSP x BN Map155.0199RGD
Cytogenetic Map15p16UniSTS
U09383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2151,000,025 - 1,000,132 (+)MAPPER
Rnor_6.0151,047,677 - 1,047,783NCBIRnor6.0
Rnor_5.0151,035,933 - 1,036,039UniSTSRnor5.0
RGSC_v3.415949,103 - 949,209UniSTSRGSC3.4
Celera153,557,333 - 3,557,439UniSTS
Cytogenetic Map15p16UniSTS
D14Mit208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215874,983 - 875,093 (+)MAPPER
Rnor_6.015927,494 - 927,603NCBIRnor6.0
Rnor_5.015916,313 - 916,422UniSTSRnor5.0
RGSC_v3.415820,431 - 820,540UniSTSRGSC3.4
Celera153,675,470 - 3,675,579UniSTS
Cytogenetic Map15p16UniSTS
BE113518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215355,078 - 355,236 (+)MAPPER
Rnor_6.015399,231 - 399,388NCBIRnor6.0
Rnor_5.015391,958 - 392,115UniSTSRnor5.0
RGSC_v3.415375,345 - 375,502UniSTSRGSC3.4
Celera154,193,257 - 4,193,414UniSTS
RH 3.4 Map1528.9UniSTS
Cytogenetic Map15p16UniSTS
WI-18797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215990,952 - 991,117 (+)MAPPER
Rnor_6.0151,038,604 - 1,038,768NCBIRnor6.0
Rnor_5.0151,026,860 - 1,027,024UniSTSRnor5.0
RGSC_v3.415940,030 - 940,194UniSTSRGSC3.4
Celera153,566,352 - 3,566,516UniSTS
Cytogenetic Map15p16UniSTS
BF386160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215711,476 - 711,641 (+)MAPPER
Rnor_6.015763,072 - 763,236NCBIRnor6.0
Rnor_5.015751,868 - 752,032UniSTSRnor5.0
RGSC_v3.415656,277 - 656,441UniSTSRGSC3.4
Celera153,838,910 - 3,839,074UniSTS
RH 3.4 Map1535.0UniSTS
Cytogenetic Map15p16UniSTS
BE101789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215530,055 - 530,205 (+)MAPPER
Rnor_6.015575,219 - 575,368NCBIRnor6.0
Rnor_5.015564,821 - 564,970UniSTSRnor5.0
Celera154,020,245 - 4,020,394UniSTS
RH 3.4 Map1531.6UniSTS
Cytogenetic Map15p16UniSTS
BF405369  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215313,741 - 313,922 (+)MAPPER
Rnor_6.015355,864 - 356,044NCBIRnor6.0
Rnor_5.015350,760 - 350,940UniSTSRnor5.0
RGSC_v3.415333,999 - 334,179UniSTSRGSC3.4
Celera154,234,546 - 4,234,726UniSTS
RH 3.4 Map1528.9UniSTS
Cytogenetic Map15p16UniSTS
Kcnma1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215871,373 - 871,451 (+)MAPPER
Rnor_6.015923,884 - 923,961NCBIRnor6.0
Rnor_5.015912,703 - 912,780UniSTSRnor5.0
RGSC_v3.415816,821 - 816,898UniSTSRGSC3.4
Celera153,679,111 - 3,679,188UniSTS
Cytogenetic Map15p16UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300142Bp191Blood pressure QTL 1913.14arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)15112800829Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15130597196Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15137708474Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15137708474Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15137708474Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15142844179Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15143521446Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:96
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000065542, ENSRNOT00000066928
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 1 1 52 4 1
Low 3 13 10 17 7 10 22 34 37 9 7
Below cutoff 28 16 16 2 16 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001393699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB248959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB248960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF083341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF083342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF091626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF135265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ517195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ517196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ517197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY330290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY330291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY330292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY330293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY330294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY344964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY344965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U40603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U55995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U93052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000065542   ⟹   ENSRNOP00000058962
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl15344,685 - 1,047,625 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000066928   ⟹   ENSRNOP00000061684
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl15344,710 - 1,047,914 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077671   ⟹   ENSRNOP00000074702
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl15344,360 - 1,047,903 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091318   ⟹   ENSRNOP00000071652
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl15675,085 - 1,047,956 (+)Ensembl
RefSeq Acc Id: NM_031828   ⟹   NP_114016
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.215302,078 - 1,001,198 (+)NCBI
Rnor_6.015344,204 - 1,048,849 (+)NCBI
Rnor_5.015339,100 - 1,037,105 (+)NCBI
RGSC_v3.415575,136 - 950,275 (+)RGD
Celera153,556,267 - 4,246,392 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_114016   ⟸   NM_031828
- Sequence:
RefSeq Acc Id: ENSRNOP00000058962   ⟸   ENSRNOT00000065542
RefSeq Acc Id: ENSRNOP00000074702   ⟸   ENSRNOT00000077671
RefSeq Acc Id: ENSRNOP00000071652   ⟸   ENSRNOT00000091318
RefSeq Acc Id: ENSRNOP00000061684   ⟸   ENSRNOT00000066928
Protein Domains
BK_channel_a   Ion_trans   RCK N-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699549
Promoter ID:EPDNEW_R10067
Type:multiple initiation site
Name:Kcnma1_1
Description:potassium calcium-activated channel subfamily M alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.015344,718 - 344,778EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620715 AgrOrtholog
Ensembl Genes ENSRNOG00000005985 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000058962 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000061684 UniProtKB/Swiss-Prot
  ENSRNOP00000071652 UniProtKB/TrEMBL
  ENSRNOP00000074702 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065542 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000066928 UniProtKB/Swiss-Prot
  ENSRNOT00000077671 UniProtKB/TrEMBL
  ENSRNOT00000091318 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ca-act_K_channel_Slo-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_BK_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83731 UniProtKB/Swiss-Prot
NCBI Gene 83731 ENTREZGENE
PANTHER PTHR10027:SF28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BK_channel_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnma1 PhenoGen
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K104_RAT UniProtKB/TrEMBL
  A0A0G2K8Q9_RAT UniProtKB/TrEMBL
  F1LNC7_RAT UniProtKB/TrEMBL
  KCMA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O08626 UniProtKB/Swiss-Prot
  O55180 UniProtKB/Swiss-Prot
  O88659 UniProtKB/Swiss-Prot
  Q7TMZ7 UniProtKB/Swiss-Prot
  Q7TMZ8 UniProtKB/Swiss-Prot
  Q7TQ55 UniProtKB/Swiss-Prot
  Q7TQ56 UniProtKB/Swiss-Prot
  Q7TQ57 UniProtKB/Swiss-Prot
  Q9WUI3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnma1  potassium calcium-activated channel subfamily M alpha 1  Kcnma1  potassium channel, calcium activated large conductance subfamily M alpha, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnma1  potassium channel, calcium activated large conductance subfamily M alpha, member 1  Kcnma1  potassium large conductance calcium-activated channel, subfamily M, alpha member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Kcnma1  potassium large conductance calcium-activated channel, subfamily M, alpha member 1  LOC498438  similar to potassium large conductance calcium-activated channel, subfamily M, alpha member 1  Data Merged 737654 PROVISIONAL
2006-11-20 LOC498438  similar to potassium large conductance calcium-activated channel, subfamily M, alpha member 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Kcnma1  potassium large conductance calcium-activated channel, subfamily M, alpha member 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kcnma1  potassium large conductance calcium-activated channel, ubfamily M, alpha member 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in adrenal chromaffin cells 625439
gene_function potassium large conductance calcium-activated channel 625439
gene_process increases repetitive firing of chromaffin cells by minimizing action potential duration and speeding recovery of sodium channels from inactivation 625439
gene_regulation production of splice variants are differentially regulated by glucocorticoids and androgens in adrenal chromaffin cells 625439
gene_regulation channel acitivity is increased in a NO-mediated fashion 633138