RGD Reference Report - Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor. - Rat Genome Database

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Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor.

Authors: Liu, G  Shi, J  Yang, L  Cao, L  Park, SM  Cui, J  Marx, SO 
Citation: Liu G, etal., EMBO J. 2004 Jun 2;23(11):2196-205. Epub 2004 May 13.
RGD ID: 2313233
Pubmed: PMID:15141163   (View Abstract at PubMed)
PMCID: PMC419908   (View Article at PubMed Central)
DOI: DOI:10.1038/sj.emboj.7600228   (Journal Full-text)

Large-conductance voltage and Ca2+-activated potassium channels (BKCa) play a critical role in modulating contractile tone of smooth muscle, and neuronal processes. In most mammalian tissues, activation of beta-adrenergic receptors and protein kinase A (PKAc) increases BKCa channel activity, contributing to sympathetic nervous system/hormonal regulation of membrane excitability. Here we report the requirement of an association of the beta2-adrenergic receptor (beta2AR) with the pore forming alpha subunit of BKCa and an A-kinase-anchoring protein (AKAP79/150) for beta2 agonist regulation. beta2AR can simultaneously interact with both BKCa and L-type Ca2+ channels (Cav1.2) in vivo, which enables the assembly of a unique, highly localized signal transduction complex to mediate Ca2+- and phosphorylation-dependent modulation of BKCa current. Our findings reveal a novel function for G protein-coupled receptors as a scaffold to couple two families of ion channels into a physical and functional signaling complex to modulate beta-adrenergic regulation of membrane excitability.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Adrb2  (adrenoceptor beta 2)
Akap5  (A-kinase anchoring protein 5)
Kcnma1  (potassium calcium-activated channel subfamily M alpha 1)


Additional Information