CDH1 (cadherin 1) - Rat Genome Database

Name: CDH1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: CDH1 (cadherin 1) Homo sapiens

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Symbol:

CDH1

Name:

cadherin 1

RGD ID:

737413

HGNC Page

HGNC:1748

Description:

Enables several functions, including GTPase activating protein binding activity; ankyrin binding activity; and beta-catenin binding activity. Involved in several processes, including cellular response to indole-3-methanol; cellular response to lithium ion; and positive regulation of protein import into nucleus. Located in several cellular components, including adherens junction; lateral plasma membrane; and trans-Golgi network. Part of catenin complex and flotillin complex. Colocalizes with cortical actin cytoskeleton. Implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; and reproductive organ cancer (multiple). Biomarker of several diseases, including endocrine gland cancer (multiple); invasive lobular carcinoma; oral squamous cell carcinoma; prostate cancer; and pulmonary fibrosis.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

Arc-1; BCDS1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin-1; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDHE; cell-CAM 120/80; E-Cadherin; E-cadherin 1; ECAD; epithelial cadherin; LCAM; truncated cadherin 1 type 1; UVO; uvomorulin

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Cdh1 (cadherin 1)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Cdh1 (cadherin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Cdh1 (cadherin 1)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	CDH1 (cadherin 1)	NCBI	Ortholog
Canis lupus familiaris (dog):	CDH1 (cadherin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cdh1 (cadherin 1)	NCBI	Ortholog
Sus scrofa (pig):	CDH1 (cadherin 1)	HGNC	EggNOG, Ensembl, NCBI, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	LOC103233229 (cadherin-1)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Cdh1 (cadherin 1)	NCBI	Ortholog
Other homologs ²
Mus musculus (house mouse):	Cdh2 (cadherin 2)	HGNC	OrthoMCL
Mus musculus (house mouse):	Cdh4 (cadherin 4)	HGNC	OrthoMCL
Mus musculus (house mouse):	Cdh3 (cadherin 3)	HGNC	OrthoMCL
Rattus norvegicus (Norway rat):	Tacstd2 (tumor-associated calcium signal transducer 2)	HGNC	OMA
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Cdh1 (cadherin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cdh1 (cadherin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-30c15.12	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	cdh1 (cadherin 1, type 1, E-cadherin (epithelial))	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Xenopus laevis (African clawed frog):	cdh1.L	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	cdh1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Xenopus laevis (African clawed frog):	cdh1.S	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	cdh3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

NCBI Annotation Information:

Note: CDH1 (GeneID 999) and FZR1 (GeneID 51343) share the CDH1 symbol. CDH1 is sometimes used as an abbreviation for 'CDC20 homolog 1' which is an alternate name for the FZR1 gene and thus can be confused with the official symbol for cadherin 1 (CDH1). [16 Jul 2018]

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	68,737,292 - 68,835,537 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	68,737,292 - 68,835,537 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	68,771,195 - 68,869,440 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	67,328,696 - 67,426,945 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	67,328,695 - 67,426,945	NCBI
Celera	16	53,280,506 - 53,378,750 (+)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	54,643,861 - 54,742,830 (+)	NCBI		HuRef
CHM1_1	16	70,179,154 - 70,277,601 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	74,533,467 - 74,631,804 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

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Model

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Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar