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Gene: CDH1 (cadherin 1) Homo sapiens
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Symbol: CDH1
Name: cadherin 1
Description: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Arc-1; BCDS1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin-1; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDHE; cell-CAM 120/80; E-Cadherin; E-cadherin 1; ECAD; epithelial cadherin; LCAM; UVO; uvomorulin
Orthologs:
Mus musculus (house mouse) : Cdh1 (cadherin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdh1 (cadherin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdh1 (cadherin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CDH1 (cadherin 1)
Canis lupus familiaris (dog) : CDH1 (cadherin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdh1 (cadherin 1)
Sus scrofa (pig) : CDH1 (cadherin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: CDH1 (GeneID 999) and FZR1 (GeneID 51343) share the CDH1 symbol. CDH1 is sometimes used as an abbreviation for 'CDC20 homolog 1' which is an alternate name for the FZR1 gene and thus can be confused with the official symbol for cadherin 1 (CDH1). [16 Jul 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381668,737,292 - 68,835,537 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371668,771,128 - 68,869,445 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361667,328,696 - 67,426,945 (+)NCBINCBI36hg18NCBI36
Build 341667,328,695 - 67,426,945NCBI
Celera1653,280,506 - 53,378,750 (+)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1654,643,861 - 54,742,830 (+)NCBIHuRef
CHM1_11670,179,152 - 70,277,602 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model