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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:27584
Term: aldosterone
Definition: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Chemical ID: MESH:D000450
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1decreases expressionISOCDH1 (Homo sapiens)6480464CTDAldosterone results in decreased expression of CDH1 mRNA; Aldosterone results in decreased expression of CDH1 proteinPMID:17596522
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTDeplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]; Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]; U 0126 inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; U 0126 inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]PMID:17596522
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