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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7374136480464CTDCelecoxib affects the expression of CDH1 protein

PMID:17224647
increases expressionISORGD:7374136480464CTDCelecoxib analog results in increased expression of CDH1 protein, Celecoxib results in increased expression of CDH1 mRNA, Celecoxib results in increased expression of CDH1 protein

PMID:19682443, PMID:29932878
multiple interactionsISORGD:7374136480464CTDCelecoxib inhibits the reaction [SNAI1 protein binds to CDH1 promoter]

PMID:29932878
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.