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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1decreases expressionEXP 6480464CTDParaquat results in decreased expression of CDH1 mRNA; Paraquat results in decreased expression of CDH1 proteinPMID:25873302 PMID:28624451 PMID:30317802 PMID:30403199
Cdh1increases expressionEXP 6480464CTDParaquat results in increased expression of CDH1 mRNAPMID:32680482
Cdh1multiple interactionsEXP 6480464CTDAnthocyanins inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]; NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 mRNA]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]; sulforaphane inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]PMID:28624451 PMID:30403199
Cdh1decreases expressionISOCDH1 (Homo sapiens)6480464CTDParaquat results in decreased expression of CDH1 mRNA; Paraquat results in decreased expression of CDH1 proteinPMID:30265375 PMID:34364922 PMID:35817254
Cdh1decreases expressionISOCdh1 (Mus musculus)6480464CTDParaquat results in decreased expression of CDH1 mRNA; Paraquat results in decreased expression of CDH1 proteinPMID:34364922 PMID:35817254
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTDHOTAIR mRNA affects the reaction [Paraquat results in decreased expression of CDH1 protein]; HPGD protein inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]; MIR17 mRNA promotes the reaction [Paraquat results in decreased expression of CDH1 protein]; sodium bisulfide inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]PMID:30265375 PMID:34364922 PMID:35817254
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