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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1affects localizationEXP 6480464CTDCadmium affects the localization of CDH1 proteinPMID:23080431
Cdh1decreases expressionISOCDH1 (Homo sapiens)6480464CTDCadmium results in decreased expression of CDH1 proteinPMID:32080757
Cdh1increases degradationISOCDH1 (Homo sapiens)6480464CTDCadmium results in increased degradation of CDH1 proteinPMID:24798214
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CDH1 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CDH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium results in increased cleavage of CDH1 protein]PMID:18791180 PMID:34687772
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