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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:76290
Term: PhIP
Definition: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Chemical ID: MESH:C049584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7374136480464CTD2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in decreased expression of CDH1 protein

PMID:22307971
decreases expressionISORGD:7374146480464CTD2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in decreased expression of CDH1 protein

PMID:22581815
multiple interactionsISORGD:7374136480464CTDU 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in decreased expression of CDH1 protein]

PMID:22307971
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.