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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDEndosulfan results in decreased expression of CDH1 mRNA

PMID:29391264
decreases expressionISORGD:7374136480464CTDEndosulfan results in decreased expression of CDH1 mRNA, Endosulfan results in decreased expression of CDH1 protein

PMID:22677888, PMID:22902829, PMID:28108160
multiple interactionsISORGD:7374136480464CTDEndosulfan inhibits the reaction [CDH1 protein binds to CTNNB1 protein]

PMID:22902829
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.