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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:85993
Term: palbociclib
Definition: A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combination with letrozole for the treatment of metastatic breast cancer.
Chemical ID: MESH:C500026
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationISORGD:7374136480464CTDpalbociclib affects the localization of CDH1 protein

PMID:22869556
multiple interactionsISORGD:7374136480464CTDCDH1 protein affects the reaction [palbociclib results in decreased expression of FOXM1 protein]

PMID:22094256
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.