GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdh1 | decreases expression | ISO | CDH1 (Homo sapiens) | 6480464 | CTD | nickel chloride results in decreased expression of CDH1 mRNA; nickel chloride results in decreased expression of CDH1 protein | PMID:22648416 | Cdh1 | increases methylation | ISO | CDH1 (Homo sapiens) | 6480464 | CTD | nickel chloride results in increased methylation of CDH1 promoter | PMID:22648416 | Cdh1 | multiple interactions | ISO | CDH1 (Homo sapiens) | 6480464 | CTD | 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in increased methylation of CDH1 promoter]; Allopurinol inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; decitabine inhibits the reaction [nickel chloride results in decreased expression of CDH1 mRNA]; HIF1A mutant form inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; nickel chloride promotes the reaction [HIF1A protein binds to CDH1 promoter]; nickel chloride promotes the reaction [SNAI1 protein binds to CDH1 promoter]; nickel chloride promotes the reaction [SNAI2 protein binds to CDH1 promoter] | PMID:22648416 | | ||||||||||||||||||||||
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