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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDQuercetin results in decreased expression of CDH1 mRNA, Quercetin results in decreased expression of CDH1 protein

PMID:28431985
multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA], Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein]

PMID:25164625
decreases expressionISORGD:7374136480464CTDQuercetin results in decreased expression of CDH1 mRNA

PMID:21632981
increases expressionISORGD:7374136480464CTDQuercetin results in increased expression of CDH1 protein

PMID:27279714
multiple interactionsISORGD:7374136480464CTDQuercetin promotes the reaction [prolinedithiocarbamate results in increased expression of CDH1 protein], Quercetin promotes the reaction [TLR4 protein affects the expression of CDH1 protein]

PMID:27279714
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.