RGD Reference Report - Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. - Rat Genome Database

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Multiple cadherin superfamily members with unique expression profiles are produced in rat testis.

Authors: Johnson, KJ  Patel, SR  Boekelheide, K 
Citation: Johnson KJ, etal., Endocrinology 2000 Feb;141(2):675-83.
RGD ID: 68759
Pubmed: PMID:10650949   (View Abstract at PubMed)
DOI: DOI:10.1210/endo.141.2.7334   (Journal Full-text)

Adhesion between germ and Sertoli cells is thought to be crucial for spermatogenesis. Cadherin superfamily proteins, including classic cadherins and protocadherins, are important mediators of cell-cell adhesion. Using a degenerate PCR cloning strategy, we surveyed the expression of cadherin superfamily members in rat testis. Similar to brain, testis expressed a large number of cadherin superfamily members: 7 classic cadherins of both types I and II, 14 protocadherins, 2 protocadherin-related cadherins, and 1 cadherin-related receptorlike protein. All three protocadherin families (alpha, beta, and gamma) were found in testis. Using a semiquantitative RT-PCR assay, messenger RNA expression was determined for each cadherin superfamily member during a postnatal developmental time-course and following ablation of specific testis cell types by ethanedimethanesulfonate, methoxyacetic acid, and 2,5-hexanedione. Diverse expression patterns were observed among the cadherins, suggesting that cadherin expression is cell type-specific in testis. The large number and variety of cadherin superfamily members found in testis supports a critical function for cadherin-mediated cell-cell adhesion in spermatogenesis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cell-cell adhesion  TAS 68759; 68759 RGD 
cell-cell adhesion  NAS 68759 RGD 
spermatogenesis  NAS 68759; 68759; 68759; 68759; 68759; 68759; 68759 RGD 
spermatogenesis  IEP 68759; 68759; 68759 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdh10  (cadherin 10)
Cdh11  (cadherin 11)
Cdh8  (cadherin 8)
Celsr2  (cadherin, EGF LAG seven-pass G-type receptor 2)
Pcdh12  (protocadherin 12)
Pcdha10  (protocadherin alpha 10)
Pcdha3  (protocadherin alpha 3)
Pcdha8  (protocadherin alpha 8)
Pcdhga11  (protocadherin gamma subfamily A, 11)
Pcdhga4  (protocadherin gamma subfamily A, 4)
Pcdhga9  (protocadherin gamma subfamily A, 9)
Pcdhgc3  (protocadherin gamma subfamily C, 3)

Objects referenced in this article
Gene Cdh1 cadherin 1 Rattus norvegicus
Gene Cdh2 cadherin 2 Rattus norvegicus
Gene Cdh3 cadherin 3 Rattus norvegicus
Gene Cdh6 cadherin 6 Rattus norvegicus
Gene Pcdha12 protocadherin alpha 12 Rattus norvegicus
Gene Pcdha4 protocadherin alpha 4 Rattus norvegicus
Gene Pcdhb19 protocadherin beta 19 Rattus norvegicus
Gene Pcdhb22 protocadherin beta 22 Rattus norvegicus
Gene Pcdhb7 protocadherin beta 7 Rattus norvegicus

Additional Information