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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:164200
Term: triclosan
Definition: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Chemical ID: MESH:D014260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1decreases expressionISOCDH1 (Homo sapiens)6480464CTDTriclosan results in decreased expression of CDH1 mRNA; Triclosan results in decreased expression of CDH1 proteinPMID:28844962 PMID:33171535
Cdh1increases expressionISOCDH1 (Homo sapiens)6480464CTDTriclosan results in increased expression of CDH1 mRNAPMID:30510588
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTD3,3'-diindolylmethane inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]; Fulvestrant inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]PMID:28844962
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