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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7374136480464CTDMethotrexate results in increased expression of CDH1 protein

PMID:21114963
increases response to substanceISORGD:7374136480464CTDCDH1 mRNA results in increased susceptibility to Methotrexate

PMID:18694510
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.