Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | RGD:737535 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Cytokine profile during latent and slowly progressive primary tuberculosis: a possible role for interleukin-15 in mediating clinical disease. | Abebe F, etal., Clin Exp Immunol. 2006 Jan;143(1):180-92. |
| 2. | Host Response Cytokine Signatures in Viral and Nonviral Acute Exacerbations of Chronic Obstructive Pulmonary Disease. | Almansa R, etal., J Interferon Cytokine Res. 2011 Jan 15. |
| 3. | IL-15 prevents allergic rhinitis through reactivation of antigen-specific CD8+ cells. | Aoi N, etal., J Allergy Clin Immunol. 2006 Jun;117(6):1359-66. Epub 2006 Apr 3. |
| 4. | Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza. | Bermejo-Martin JF, etal., Crit Care. 2009;13(6):R201. Epub 2009 Dec 11. |
| 5. | Confirmation of association of IL-15 with pediatric asthma and comparison of different controls. | Bierbaum S, etal., Allergy. 2006 May;61(5):576-80. |
| 6. | Autocrine role of vascular IL-15 in intimal thickening. | Cercek M, etal., Biochem Biophys Res Commun. 2006 Jan 13;339(2):618-23. Epub 2005 Nov 18. |
| 7. | Differential diagnosis of pleural effusions by fuzzy-logic-based analysis of cytokines. | Chomej P, etal., Respir Med. 2004 Apr;98(4):308-17. |
| 8. | Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis. | Desai B, etal., Exp Lung Res. 2011 May;37(4):227-38. Epub 2011 Feb 11. |
| 9. | Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. | Galkowska H, etal., Wound Repair Regen. 2006 Sep-Oct;14(5):558-65. |
| 10. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 11. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 12. | 1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice. | Gysemans CA, etal., Endocrinology. 2005 Apr;146(4):1956-64. Epub 2005 Jan 6. |
| 13. | Clinical aspects and cytokine response in severe H1N1 influenza A virus infection. | Hagau N, etal., Crit Care. 2010;14(6):R203. Epub 2010 Nov 9. |
| 14. | Interleukin-15 may be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats. | Hirose K, etal., Infect Immun. 1998 Dec;66(12):5677-83. |
| 15. | Cell-specific interleukin-15 and interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia--comparison to chlamydial lung infection. | Hocke AC, etal., Cytokine. 2007 May;38(2):61-73. Epub 2007 Jul 3. |
| 16. | Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in a murine model of asthma. | Ishimitsu R, etal., J Immunol. 2001 Feb 1;166(3):1991-2001. |
| 17. | Interleukin-15 inhibits smooth muscle cell proliferation and hyaluronan production in rat ductus arteriosus. | Iwasaki S, etal., Pediatr Res. 2007 Oct;62(4):392-8. |
| 18. | Serum interleukin-15 concentration in patients with essential hypertension. | Kaibe M, etal., Am J Hypertens. 2005 Aug;18(8):1019-25. |
| 19. | Significant expression of interleukin 15 in rat experimental severe acute pancreatitis. | Kamei K, etal., Eur Surg Res. 2010;44(3-4):159-69. Epub 2010 Mar 24. |
| 20. | Synergistic effect of interleukin-15 and interleukin-12 on antitumor activity in a murine malignant pleurisy model. | Kimura K, etal., Cancer Immunol Immunother. 2000 May;49(2):71-7. |
| 21. | Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. | Koulmanda M, etal., Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13074-9. Epub 2007 Aug 1. |
| 22. | IL-15 is elevated in serum patients with type 1 diabetes mellitus. | Kuczynski S, etal., Diabetes Res Clin Pract. 2005 Sep;69(3):231-6. Epub 2005 Mar 31. |
| 23. | Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis. | Kuniyasu H, etal., Clin Cancer Res 2003 Oct 15;9(13):4802-10. |
| 24. | Multilocus haplotype analyses reveal association between 5 novel IL-15 polymorphisms and asthma. | Kurz T, etal., J Allergy Clin Immunol. 2004 May;113(5):896-901. |
| 25. | Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues. | Lacraz G, etal., PLoS One. 2016 Sep 29;11(9):e0162995. doi: 10.1371/journal.pone.0162995. eCollection 2016. |
| 26. | Interleukin-15 is associated with disease severity in viral bronchiolitis. | Leahy TR, etal., Eur Respir J. 2016 Jan;47(1):212-22. doi: 10.1183/13993003.00642-2015. Epub 2015 Nov 5. |
| 27. | Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. | Li Y, etal., Mol Oral Microbiol. 2010 Aug;25(4):275-92. |
| 28. | Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction. | Marzetti E, etal., Mech Ageing Dev. 2009 Apr;130(4):272-80. |
| 29. | Proinflammatory cytokines in injured rat brain following perinatal asphyxia. | Maslinska D, etal., Folia Neuropathol. 2002;40(4):177-82. |
| 30. | IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection. | McGill J, etal., J Exp Med. 2010 Mar 15;207(3):521-34. Epub 2010 Mar 8. |
| 31. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 32. | Gr-1high polymorphonuclear leukocytes and NK cells act via IL-15 to clear intracellular Haemophilus influenzae in experimental murine peritonitis and pneumonia. | Miyazaki S, etal., J Immunol. 2007 Oct 15;179(8):5407-14. |
| 33. | Expression of IL-15 in inflammatory pulmonary diseases. | Muro S, etal., J Allergy Clin Immunol. 2001 Dec;108(6):970-5. |
| 34. | Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury. | Nakamura R, etal., J Virol. 2010 Jun;84(11):5574-82. Epub 2010 Mar 24. |
| 35. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 36. | Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass. | Nielsen AR, etal., J Clin Endocrinol Metab. 2008 Nov;93(11):4486-93. Epub 2008 Aug 12. |
| 37. | Inflammation and functional outcome in diisocyanate-induced asthma after cessation of exposure. | Piirila PL, etal., Allergy. 2008 May;63(5):583-91. |
| 38. | IL15 gene variants are not associated with asthma and atopy. | Pinto LA, etal., Allergy. 2009 Apr;64(4):643-6. Epub 2008 Dec 24. |
| 39. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 40. | Interleukin-15 responses to aging and unloading-induced skeletal muscle atrophy. | Pistilli EE, etal., Am J Physiol Cell Physiol. 2007 Apr;292(4):C1298-304. Epub 2006 Nov 29. |
| 41. | Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in mice. | Poon LL, etal., J Immunol. 2009 Mar 1;182(5):3063-71. |
| 42. | A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats. | Qaisar N, etal., Diabetes. 2017 Jan;66(1):145-157. doi: 10.2337/db16-0462. Epub 2016 Oct 7. |
| 43. | Natural killer cell-mediated cytokine response among HIV-positive south Indians with pulmonary tuberculosis. | Ramana Rao PV, etal., J Interferon Cytokine Res. 2010 Jan;30(1):33-42. |
| 44. | Intestinal epithelial cells both express and respond to interleukin 15. | Reinecker HC, etal., Gastroenterology. 1996 Dec;111(6):1706-13. |
| 45. | Natural killer-cell deficiency alters placental development in rats. | Renaud SJ, etal., Biol Reprod. 2017 Jan 1;96(1):145-158. doi: 10.1095/biolreprod.116.142752. |
| 46. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 47. | Comprehensive gene review and curation | RGD comprehensive gene curation |
| 48. | Immunoregulation during disease progression in prediabetic NOD mice: inverse expression of arginase and prostaglandin H synthase 2 vs. interleukin-15. | Rothe H, etal., Horm Metab Res. 2002 Jan;34(1):7-12. |
| 49. | Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo. | Ruckert R, etal., J Immunol. 2005 May 1;174(9):5507-15. |
| 50. | Cytokine profiling of pulmonary aspergillosis. | Sambatakou H, etal., Int J Immunogenet. 2006 Aug;33(4):297-302. |
| 51. | NK cells play a critical protective role in host defense against acute extracellular Staphylococcus aureus bacterial infection in the lung. | Small CL, etal., J Immunol. 2008 Apr 15;180(8):5558-68. |
| 52. | Inhibition of lymphocyte apoptosis by pancreatic stellate cells: impact of interleukin-15. | Sparmann G, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G842-51. Epub 2005 Jul 7. |
| 53. | Myocytes respond in vivo to an antibody reactive with the acetylcholine receptor by upregulating interleukin-15: an interferon-gamma activator with the potential to influence the severity and course of experimental myasthenia gravis. | Stegall T and Krolick KA, J Neuroimmunol. 2001 Oct 1;119(2):377-86. |
| 54. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 55. | A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection. | Verbist KC, etal., J Immunol. 2011 Jan 1;186(1):174-82. Epub 2010 Nov 22. |
| 56. | Effects of interleukin-15 on suppression of rat pancreatic islets in vitro induced by proinflammatory cytokines. | Wallstrom J, etal., Immunol Lett 2003 Aug 5;88(2):141-5. |
| 57. | Interleukin-15 receptor-directed immunotoxins atteunuate disease severity in rat adjuvant arthritis. | Wang D, etal., Mol Immunol. 2010 Apr;47(7-8):1535-43. Epub 2010 Feb 25. |
| 58. | Increased expression of non-interleukin-2 T cell growth factors and their implications during liver allograft rejection in rats. | Wang WL, etal., J Gastroenterol Hepatol. 2007 Jul;22(7):1141-7. Epub 2007 May 27. |
| 59. | Expression of interleukin-15 in mouse and human atherosclerotic lesions. | Wuttge DM, etal., Am J Pathol. 2001 Aug;159(2):417-23. |
| 60. | Serum IL-15 in patients with early systemic sclerosis: a potential novel marker of lung disease. | Wuttge DM, etal., Arthritis Res Ther. 2007;9(5):R85. |
Additional References at PubMed
| PMID:10704459 | PMID:11737071 | PMID:12244150 | PMID:12477932 | PMID:14607906 | PMID:15123770 | PMID:16405651 | PMID:16482511 | PMID:17318811 | PMID:18239634 | PMID:19747902 | PMID:20450731 |
| PMID:23017227 | PMID:24006180 | PMID:24509081 | PMID:24942581 | PMID:25522723 | PMID:29097254 | PMID:33010727 |
Genomics
Comparative Map Data
| Il15 (Rattus norvegicus - Norway rat) |
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| IL15 (Homo sapiens - human) |
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| Il15 (Mus musculus - house mouse) |
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| Il15 (Chinchilla lanigera - long-tailed chinchilla) |
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| IL15 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| IL15 (Canis lupus familiaris - dog) |
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| Il15 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| IL15 (Sus scrofa - pig) |
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| IL15 (Chlorocebus sabaeus - green monkey) |
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| Il15 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Il15
309 total Variants 
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