Il15 (interleukin 15) - Rat Genome Database

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Gene: Il15 (interleukin 15) Rattus norvegicus
Analyze
Symbol: Il15
Name: interleukin 15
RGD ID: 2887
Description: Predicted to enable cytokine activity. Involved in several processes, including cellular response to vitamin D; positive regulation of tyrosine phosphorylation of STAT protein; and skeletal muscle atrophy. Located in cell surface and extracellular space. Used to study pancreatitis. Biomarker of listeriosis and periodontal disease. Human ortholog(s) of this gene implicated in aspergillosis; asthma; pleurisy; and type 1 diabetes mellitus. Orthologous to human IL15 (interleukin 15); PARTICIPATES IN Jak-Stat signaling pathway; cytokine mediated signaling pathway; rheumatoid arthritis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL-15; interleukin-15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Il15em1Soar  
Genetic Models: SD-Il15em1Soar
Is Marker For: Strains:   SD-Il15em1Soar  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21925,640,013 - 25,706,818 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1925,640,251 - 25,706,820 (+)Ensembl
Rnor_6.01923,542,606 - 23,624,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1923,542,889 - 23,554,594 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01934,532,033 - 34,598,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41927,487,268 - 27,498,973 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11927,437,760 - 27,504,081 (+)NCBI
Celera1925,228,574 - 25,240,279 (+)NCBICelera
Celera1925,174,648 - 25,228,568 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-Nitrobenzanthrone  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-penicillamine  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (ISO)
diethyl malate  (ISO)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
emodin  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hexachlorobenzene  (EXP)
hydroquinone  (ISO)
irinotecan  (EXP)
levamisole  (ISO)
lipid As  (ISO)
lipopolysaccharide  (ISO)
m-xylene  (EXP)
methyl methanesulfonate  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nonanoic acid  (ISO)
notoginsenoside R1  (ISO)
Olmesartan medoxomil  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PD 0325901  (ISO)
permethrin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
Pyridostigmine bromide  (EXP)
quercitrin  (ISO)
quinolin-8-ol  (ISO)
riddelliine  (EXP)
rotenone  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sterigmatocystin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IDA)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
extracellular space  (IBA,IDA)
nuclear speck  (IEA,ISO)
nucleoplasm  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Cytokine profile during latent and slowly progressive primary tuberculosis: a possible role for interleukin-15 in mediating clinical disease. Abebe F, etal., Clin Exp Immunol. 2006 Jan;143(1):180-92.
2. Host Response Cytokine Signatures in Viral and Nonviral Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Almansa R, etal., J Interferon Cytokine Res. 2011 Jan 15.
3. IL-15 prevents allergic rhinitis through reactivation of antigen-specific CD8+ cells. Aoi N, etal., J Allergy Clin Immunol. 2006 Jun;117(6):1359-66. Epub 2006 Apr 3.
4. Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza. Bermejo-Martin JF, etal., Crit Care. 2009;13(6):R201. Epub 2009 Dec 11.
5. Confirmation of association of IL-15 with pediatric asthma and comparison of different controls. Bierbaum S, etal., Allergy. 2006 May;61(5):576-80.
6. Autocrine role of vascular IL-15 in intimal thickening. Cercek M, etal., Biochem Biophys Res Commun. 2006 Jan 13;339(2):618-23. Epub 2005 Nov 18.
7. Differential diagnosis of pleural effusions by fuzzy-logic-based analysis of cytokines. Chomej P, etal., Respir Med. 2004 Apr;98(4):308-17.
8. Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis. Desai B, etal., Exp Lung Res. 2011 May;37(4):227-38. Epub 2011 Feb 11.
9. Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. Galkowska H, etal., Wound Repair Regen. 2006 Sep-Oct;14(5):558-65.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. 1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice. Gysemans CA, etal., Endocrinology. 2005 Apr;146(4):1956-64. Epub 2005 Jan 6.
13. Clinical aspects and cytokine response in severe H1N1 influenza A virus infection. Hagau N, etal., Crit Care. 2010;14(6):R203. Epub 2010 Nov 9.
14. Interleukin-15 may be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats. Hirose K, etal., Infect Immun. 1998 Dec;66(12):5677-83.
15. Cell-specific interleukin-15 and interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia--comparison to chlamydial lung infection. Hocke AC, etal., Cytokine. 2007 May;38(2):61-73. Epub 2007 Jul 3.
16. Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in a murine model of asthma. Ishimitsu R, etal., J Immunol. 2001 Feb 1;166(3):1991-2001.
17. Interleukin-15 inhibits smooth muscle cell proliferation and hyaluronan production in rat ductus arteriosus. Iwasaki S, etal., Pediatr Res. 2007 Oct;62(4):392-8.
18. Serum interleukin-15 concentration in patients with essential hypertension. Kaibe M, etal., Am J Hypertens. 2005 Aug;18(8):1019-25.
19. Significant expression of interleukin 15 in rat experimental severe acute pancreatitis. Kamei K, etal., Eur Surg Res. 2010;44(3-4):159-69. Epub 2010 Mar 24.
20. Synergistic effect of interleukin-15 and interleukin-12 on antitumor activity in a murine malignant pleurisy model. Kimura K, etal., Cancer Immunol Immunother. 2000 May;49(2):71-7.
21. Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Koulmanda M, etal., Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13074-9. Epub 2007 Aug 1.
22. IL-15 is elevated in serum patients with type 1 diabetes mellitus. Kuczynski S, etal., Diabetes Res Clin Pract. 2005 Sep;69(3):231-6. Epub 2005 Mar 31.
23. Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis. Kuniyasu H, etal., Clin Cancer Res 2003 Oct 15;9(13):4802-10.
24. Multilocus haplotype analyses reveal association between 5 novel IL-15 polymorphisms and asthma. Kurz T, etal., J Allergy Clin Immunol. 2004 May;113(5):896-901.
25. Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues. Lacraz G, etal., PLoS One. 2016 Sep 29;11(9):e0162995. doi: 10.1371/journal.pone.0162995. eCollection 2016.
26. Interleukin-15 is associated with disease severity in viral bronchiolitis. Leahy TR, etal., Eur Respir J. 2016 Jan;47(1):212-22. doi: 10.1183/13993003.00642-2015. Epub 2015 Nov 5.
27. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Li Y, etal., Mol Oral Microbiol. 2010 Aug;25(4):275-92.
28. Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction. Marzetti E, etal., Mech Ageing Dev. 2009 Apr;130(4):272-80.
29. Proinflammatory cytokines in injured rat brain following perinatal asphyxia. Maslinska D, etal., Folia Neuropathol. 2002;40(4):177-82.
30. IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection. McGill J, etal., J Exp Med. 2010 Mar 15;207(3):521-34. Epub 2010 Mar 8.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Gr-1high polymorphonuclear leukocytes and NK cells act via IL-15 to clear intracellular Haemophilus influenzae in experimental murine peritonitis and pneumonia. Miyazaki S, etal., J Immunol. 2007 Oct 15;179(8):5407-14.
33. Expression of IL-15 in inflammatory pulmonary diseases. Muro S, etal., J Allergy Clin Immunol. 2001 Dec;108(6):970-5.
34. Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury. Nakamura R, etal., J Virol. 2010 Jun;84(11):5574-82. Epub 2010 Mar 24.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass. Nielsen AR, etal., J Clin Endocrinol Metab. 2008 Nov;93(11):4486-93. Epub 2008 Aug 12.
37. Inflammation and functional outcome in diisocyanate-induced asthma after cessation of exposure. Piirila PL, etal., Allergy. 2008 May;63(5):583-91.
38. IL15 gene variants are not associated with asthma and atopy. Pinto LA, etal., Allergy. 2009 Apr;64(4):643-6. Epub 2008 Dec 24.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. Interleukin-15 responses to aging and unloading-induced skeletal muscle atrophy. Pistilli EE, etal., Am J Physiol Cell Physiol. 2007 Apr;292(4):C1298-304. Epub 2006 Nov 29.
41. Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in mice. Poon LL, etal., J Immunol. 2009 Mar 1;182(5):3063-71.
42. A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats. Qaisar N, etal., Diabetes. 2017 Jan;66(1):145-157. doi: 10.2337/db16-0462. Epub 2016 Oct 7.
43. Natural killer cell-mediated cytokine response among HIV-positive south Indians with pulmonary tuberculosis. Ramana Rao PV, etal., J Interferon Cytokine Res. 2010 Jan;30(1):33-42.
44. Intestinal epithelial cells both express and respond to interleukin 15. Reinecker HC, etal., Gastroenterology. 1996 Dec;111(6):1706-13.
45. Natural killer-cell deficiency alters placental development in rats. Renaud SJ, etal., Biol Reprod. 2017 Jan 1;96(1):145-158. doi: 10.1095/biolreprod.116.142752.
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Comprehensive gene review and curation RGD comprehensive gene curation
48. Immunoregulation during disease progression in prediabetic NOD mice: inverse expression of arginase and prostaglandin H synthase 2 vs. interleukin-15. Rothe H, etal., Horm Metab Res. 2002 Jan;34(1):7-12.
49. Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo. Ruckert R, etal., J Immunol. 2005 May 1;174(9):5507-15.
50. Cytokine profiling of pulmonary aspergillosis. Sambatakou H, etal., Int J Immunogenet. 2006 Aug;33(4):297-302.
51. NK cells play a critical protective role in host defense against acute extracellular Staphylococcus aureus bacterial infection in the lung. Small CL, etal., J Immunol. 2008 Apr 15;180(8):5558-68.
52. Inhibition of lymphocyte apoptosis by pancreatic stellate cells: impact of interleukin-15. Sparmann G, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G842-51. Epub 2005 Jul 7.
53. Myocytes respond in vivo to an antibody reactive with the acetylcholine receptor by upregulating interleukin-15: an interferon-gamma activator with the potential to influence the severity and course of experimental myasthenia gravis. Stegall T and Krolick KA, J Neuroimmunol. 2001 Oct 1;119(2):377-86.
54. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
55. A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection. Verbist KC, etal., J Immunol. 2011 Jan 1;186(1):174-82. Epub 2010 Nov 22.
56. Effects of interleukin-15 on suppression of rat pancreatic islets in vitro induced by proinflammatory cytokines. Wallstrom J, etal., Immunol Lett 2003 Aug 5;88(2):141-5.
57. Interleukin-15 receptor-directed immunotoxins atteunuate disease severity in rat adjuvant arthritis. Wang D, etal., Mol Immunol. 2010 Apr;47(7-8):1535-43. Epub 2010 Feb 25.
58. Increased expression of non-interleukin-2 T cell growth factors and their implications during liver allograft rejection in rats. Wang WL, etal., J Gastroenterol Hepatol. 2007 Jul;22(7):1141-7. Epub 2007 May 27.
59. Expression of interleukin-15 in mouse and human atherosclerotic lesions. Wuttge DM, etal., Am J Pathol. 2001 Aug;159(2):417-23.
60. Serum IL-15 in patients with early systemic sclerosis: a potential novel marker of lung disease. Wuttge DM, etal., Arthritis Res Ther. 2007;9(5):R85.
Additional References at PubMed
PMID:10704459   PMID:11737071   PMID:12244150   PMID:12477932   PMID:14607906   PMID:15123770   PMID:16405651   PMID:16482511   PMID:17318811   PMID:18239634   PMID:19747902   PMID:20450731  
PMID:23017227   PMID:24006180   PMID:24509081   PMID:24942581   PMID:25522723   PMID:29097254   PMID:33010727  


Genomics

Comparative Map Data
Il15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21925,640,013 - 25,706,818 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1925,640,251 - 25,706,820 (+)Ensembl
Rnor_6.01923,542,606 - 23,624,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1923,542,889 - 23,554,594 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01934,532,033 - 34,598,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41927,487,268 - 27,498,973 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11927,437,760 - 27,504,081 (+)NCBI
Celera1925,228,574 - 25,240,279 (+)NCBICelera
Celera1925,174,648 - 25,228,568 (+)NCBICelera
Cytogenetic Map19q11NCBI
IL15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384141,636,583 - 141,733,987 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4141,636,583 - 141,733,987 (+)EnsemblGRCh38hg38GRCh38
GRCh374142,557,736 - 142,655,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364142,777,204 - 142,874,062 (+)NCBINCBI36hg18NCBI36
Build 344142,997,904 - 143,012,216NCBI
Celera4139,888,493 - 139,985,377 (+)NCBI
Cytogenetic Map4q31.21NCBI
HuRef4138,287,515 - 138,384,970 (+)NCBIHuRef
CHM1_14142,535,127 - 142,632,588 (+)NCBICHM1_1
T2T-CHM13v2.04144,953,939 - 145,051,309 (+)NCBI
Il15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39883,058,253 - 83,129,883 (-)NCBIGRCm39mm39
GRCm39 Ensembl883,058,261 - 83,129,851 (-)Ensembl
GRCm38882,331,624 - 82,403,252 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl882,331,632 - 82,403,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37884,855,523 - 84,926,444 (-)NCBIGRCm37mm9NCBIm37
MGSCv36885,227,371 - 85,298,292 (-)NCBImm8
Celera886,620,550 - 86,691,831 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map839.33NCBI
Il15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554711,497,483 - 1,511,469 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554711,496,352 - 1,583,919 (-)NCBIChiLan1.0ChiLan1.0
IL15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14145,307,339 - 145,416,622 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4145,402,111 - 145,416,622 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04133,693,995 - 134,115,470 (+)NCBIMhudiblu_PPA_v0panPan3
IL15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1191,339,607 - 1,364,762 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl191,339,967 - 1,364,762 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha191,586,489 - 1,611,118 (-)NCBI
ROS_Cfam_1.0191,361,003 - 1,425,159 (-)NCBI
ROS_Cfam_1.0 Ensembl191,361,363 - 1,373,768 (-)Ensembl
UMICH_Zoey_3.1191,341,699 - 1,366,271 (-)NCBI
UNSW_CanFamBas_1.0191,703,298 - 1,727,862 (-)NCBI
UU_Cfam_GSD_1.0192,058,426 - 2,083,219 (-)NCBI
Il15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530148,906,307 - 48,919,895 (-)NCBI
SpeTri2.0NW_0049365356,344,348 - 6,358,803 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl885,667,307 - 85,740,911 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1885,666,963 - 85,740,980 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2890,963,736 - 91,036,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1788,548,773 - 88,644,977 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl788,548,671 - 88,645,488 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603768,097,083 - 68,194,427 (+)NCBIVero_WHO_p1.0
Il15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248531,128,519 - 1,144,941 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248531,059,625 - 1,144,799 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D19Rat12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21925,704,671 - 25,704,884 (-)MAPPERmRatBN7.2
Rnor_6.01923,544,543 - 23,544,753NCBIRnor6.0
Rnor_5.01934,533,970 - 34,534,180UniSTSRnor5.0
RGSC_v3.41927,497,108 - 27,497,319RGDRGSC3.4
RGSC_v3.41927,497,109 - 27,497,319UniSTSRGSC3.4
RGSC_v3.11927,501,934 - 27,502,145RGD
Celera1925,238,415 - 25,238,625UniSTS
SHRSP x BN Map1920.2599UniSTS
SHRSP x BN Map1920.2599RGD
FHH x ACI Map1921.16RGD
Cytogenetic Map19q11UniSTS
RH127909  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21925,706,452 - 25,706,655 (-)MAPPERmRatBN7.2
Rnor_6.01923,542,772 - 23,542,974NCBIRnor6.0
Rnor_5.01934,532,199 - 34,532,401UniSTSRnor5.0
RGSC_v3.41927,498,888 - 27,499,090UniSTSRGSC3.4
Celera1925,240,194 - 25,240,396UniSTS
Cytogenetic Map19q11UniSTS
RH94635  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21925,706,622 - 25,706,804 (-)MAPPERmRatBN7.2
Rnor_6.01923,542,623 - 23,542,804NCBIRnor6.0
Rnor_5.01934,532,050 - 34,532,231UniSTSRnor5.0
RGSC_v3.41927,499,058 - 27,499,239UniSTSRGSC3.4
Celera1925,240,364 - 25,240,545UniSTS
Cytogenetic Map19q11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat


Related Rat Strains
The following Strains have been annotated to Il15


Genetic Models
This gene Il15 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:279
Count of miRNA genes:184
Interacting mature miRNAs:219
Transcripts:ENSRNOT00000004590
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 9 9 1 19 1 4 7 25 21 11 4
Low 34 48 40 40 4 4 70 10 20 4
Below cutoff 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001401135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF015718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF015719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U69272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000004590   ⟹   ENSRNOP00000004590
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1925,695,560 - 25,706,820 (+)Ensembl
Rnor_6.0 Ensembl1923,542,889 - 23,554,594 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109879   ⟹   ENSRNOP00000077234
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1925,640,251 - 25,706,820 (+)Ensembl
RefSeq Acc Id: NM_013129   ⟹   NP_037261
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,694,831 - 25,706,538 (+)NCBI
Rnor_6.01923,542,889 - 23,554,594 (-)NCBI
Rnor_5.01934,532,033 - 34,598,725 (-)NCBI
RGSC_v3.41927,487,268 - 27,498,973 (+)RGD
Celera1925,228,574 - 25,240,279 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772424   ⟹   XP_008770646
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,428 - 25,694,810 (+)NCBI
Rnor_6.01923,554,603 - 23,610,053 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601186   ⟹   XP_017456675
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,081 - 25,706,818 (+)NCBI
Rnor_6.01923,542,606 - 23,610,033 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601187   ⟹   XP_017456676
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,081 - 25,706,818 (+)NCBI
Rnor_6.01923,542,606 - 23,610,033 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601190   ⟹   XP_017456679
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,013 - 25,668,959 (+)NCBI
Rnor_6.01923,583,944 - 23,610,050 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097502   ⟹   XP_038953430
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,428 - 25,692,544 (+)NCBI
RefSeq Acc Id: XM_039097503   ⟹   XP_038953431
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,428 - 25,669,137 (+)NCBI
RefSeq Acc Id: XM_039097504   ⟹   XP_038953432
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,428 - 25,668,959 (+)NCBI
RefSeq Acc Id: XM_039097505   ⟹   XP_038953433
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,428 - 25,688,491 (+)NCBI
RefSeq Acc Id: XM_039097506   ⟹   XP_038953434
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,015 - 25,694,765 (+)NCBI
RefSeq Acc Id: XM_039097507   ⟹   XP_038953435
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,025 - 25,694,810 (+)NCBI
RefSeq Acc Id: XM_039097508   ⟹   XP_038953436
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,081 - 25,706,818 (+)NCBI
RefSeq Acc Id: XM_039097509   ⟹   XP_038953437
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,079 - 25,706,818 (+)NCBI
RefSeq Acc Id: XM_039097510   ⟹   XP_038953438
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,079 - 25,706,818 (+)NCBI
RefSeq Acc Id: XM_039097511   ⟹   XP_038953439
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,674,718 - 25,706,818 (+)NCBI
RefSeq Acc Id: XM_039097512   ⟹   XP_038953440
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,080 - 25,706,818 (+)NCBI
RefSeq Acc Id: XM_039097513   ⟹   XP_038953441
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,080 - 25,706,818 (+)NCBI
RefSeq Acc Id: XM_039097514   ⟹   XP_038953442
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,080 - 25,706,818 (+)NCBI
RefSeq Acc Id: XM_039097515   ⟹   XP_038953443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,079 - 25,706,818 (+)NCBI
RefSeq Acc Id: XM_039097516   ⟹   XP_038953444
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,079 - 25,706,818 (+)NCBI
RefSeq Acc Id: XM_039097517   ⟹   XP_038953445
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,079 - 25,706,818 (+)NCBI
RefSeq Acc Id: XM_039097518   ⟹   XP_038953446
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,016 - 25,669,137 (+)NCBI
RefSeq Acc Id: XM_039097519   ⟹   XP_038953447
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,015 - 25,694,803 (+)NCBI
RefSeq Acc Id: XM_039097520   ⟹   XP_038953448
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21925,640,072 - 25,706,818 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388064 (Get FASTA)   NCBI Sequence Viewer  
  NP_037261 (Get FASTA)   NCBI Sequence Viewer  
  XP_008770646 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456675 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456676 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456679 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953430 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953431 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953432 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953433 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953434 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953435 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953436 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953437 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953438 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953439 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953440 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953441 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953442 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953443 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953444 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953445 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953446 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953447 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953448 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB41697 (Get FASTA)   NCBI Sequence Viewer  
  AAB94535 (Get FASTA)   NCBI Sequence Viewer  
  AAB94536 (Get FASTA)   NCBI Sequence Viewer  
  EDL92290 (Get FASTA)   NCBI Sequence Viewer  
  EDL92291 (Get FASTA)   NCBI Sequence Viewer  
  P97604 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037261   ⟸   NM_013129
- Peptide Label: precursor
- UniProtKB: P97604 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017456676   ⟸   XM_017601187
- Peptide Label: isoform X6
- UniProtKB: P97604 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017456675   ⟸   XM_017601186
- Peptide Label: isoform X6
- UniProtKB: P97604 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008770646   ⟸   XM_008772424
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017456679   ⟸   XM_017601190
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000004590   ⟸   ENSRNOT00000004590
RefSeq Acc Id: XP_038953447   ⟸   XM_039097519
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038953434   ⟸   XM_039097506
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038953446   ⟸   XM_039097518
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038953435   ⟸   XM_039097507
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038953448   ⟸   XM_039097520
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038953438   ⟸   XM_039097510
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038953437   ⟸   XM_039097509
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038953443   ⟸   XM_039097515
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038953444   ⟸   XM_039097516
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038953445   ⟸   XM_039097517
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038953440   ⟸   XM_039097512
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038953441   ⟸   XM_039097513
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038953442   ⟸   XM_039097514
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038953436   ⟸   XM_039097508
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038953430   ⟸   XM_039097502
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953433   ⟸   XM_039097505
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953431   ⟸   XM_039097503
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953432   ⟸   XM_039097504
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953439   ⟸   XM_039097511
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000077234   ⟸   ENSRNOT00000109879

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97604-F1-model_v2 AlphaFold P97604 1-162 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
19 23553431 23553432 T C snv F344/NRrrc (MCW), Buf/N (MCW), M520/N (MCW)
19 23608525 23608526 C G snv FHL/EurMcwi (MCW), FHH/EurMcwi (2019), FHL/EurMcwi (RGD), FHH/EurMcwi (RGD), FHH/EurMcwi (MCW)
19 23608617 23608618 A G snv FHH/EurMcwi (MCW), FHH/EurMcwi (RGD), FHL/EurMcwi (MCW), FHH/EurMcwi (2019), FHL/EurMcwi (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2887 AgrOrtholog
BioCyc Gene G2FUF-5985 BioCyc
Ensembl Genes ENSRNOG00000003439 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000004590 ENTREZGENE
  ENSRNOP00000077234 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004590 ENTREZGENE
  ENSRNOT00000109879 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.70 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-15 UniProtKB/Swiss-Prot
  IL-15/IL-21_fam UniProtKB/Swiss-Prot
  IL-15_mml UniProtKB/Swiss-Prot
KEGG Report rno:25670 UniProtKB/Swiss-Prot
NCBI Gene 25670 ENTREZGENE
PANTHER PTHR14356 UniProtKB/Swiss-Prot
Pfam IL15 UniProtKB/Swiss-Prot
PhenoGen Il15 PhenoGen
PRINTS INTLKN15MAML UniProtKB/Swiss-Prot
  INTRLEUKIN15 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
TIGR TC221104
UniProt IL15_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O54847 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il15  Interleukin 15      Symbol and Name status set to approved 70586 APPROVED