RGD Reference Report - Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis. - Rat Genome Database

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Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis.

Authors: Desai, B  Mattson, J  Paintal, H  Nathan, M  Shen, F  Beaumont, M  Malinao, MC  Li, Y  Canfield, J  Basham, B  De Waal Malefyt, R  McClanahan, T  Krishna, G  Fick R, JR 
Citation: Desai B, etal., Exp Lung Res. 2011 May;37(4):227-38. Epub 2011 Feb 11.
RGD ID: 5147438
Pubmed: PMID:21309737   (View Abstract at PubMed)
DOI: DOI:10.3109/01902148.2010.538132   (Journal Full-text)

Idiopathic interstitial pneumonias are a group of idiopathic interstitial lung diseases of which idiopathic pulmonary fibrosis (IPF) is the lesion of usual interstitial pneumonia. Although the pathogenic mechanisms remain incompletely understood, disease-specific changes in blood, a readily accessible biospecimen, have not been fully characterized. To identify biomarkers from blood and sera, the immune status of IPF patients and control subjects without structural lung disease was quantified by measuring cell surface markers, mRNA levels, and serum proteins. Statistically significant differences in cellular and molecular markers were observed between the 2 groups. The cytokine receptor IL-17RB was significantly higher in CD14+ peripheral blood mononuclear cells (PBMCs) from IPF patients, whereas expression of the chemokine receptor CXCR4 was lower. Gene expression analyses identified 18 differentially expressed genes out of 195 selected. Of these, EMR1, CCR3, UPAR, FCGR2A, OPN, CEACAM3, CD16a, CD18, CD11b, LTF, and LCN2 were up-regulated, whereas IL-17RB, IL-10, PDGFA, CD301/Clec10a, CD25/IL-2RA, IL-23p19, and IL-15 were down-regulated in IPF. Differentially regulated genes were in the functional areas of inflammation and cell signaling. Serum levels of UPAR and OPN were higher in IPF. These observations reveal significant differences in cell and molecular markers involved in monocyte/macrophage activation and migration, and suggest a role for IL-17RB in IPF.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Il15  (interleukin 15)
Il2ra  (interleukin 2 receptor subunit alpha)

Genes (Mus musculus)
Il15  (interleukin 15)
Il2ra  (interleukin 2 receptor, alpha chain)

Genes (Homo sapiens)
IL15  (interleukin 15)
IL2RA  (interleukin 2 receptor subunit alpha)


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