RGD Reference Report - Interleukin-15 is associated with disease severity in viral bronchiolitis. - Rat Genome Database

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Interleukin-15 is associated with disease severity in viral bronchiolitis.

Authors: Leahy, T Ronan  McManus, Ross  Doherty, Derek G  Grealy, Robert  Coulter, Tanya  Smyth, Paul  Blackshields, Gordon  Sheils, Orla  Carr, Michael J  Purandare, Nikhil  Geary, Michael  Hodemaekers, Hennie M  Janssen, Riny  Bont, Louis  Slattery, Dubhfeasa  Ryan, Thomas 
Citation: Leahy TR, etal., Eur Respir J. 2016 Jan;47(1):212-22. doi: 10.1183/13993003.00642-2015. Epub 2015 Nov 5.
RGD ID: 40902860
Pubmed: (View Article at PubMed) PMID:26541527
DOI: Full-text: DOI:10.1183/13993003.00642-2015

Disease severity in viral bronchiolitis in infancy is difficult to predict and has been linked to host innate immunity. The study aimed to investigate the innate cytokine interleukin-15 (IL-15) as a marker of disease severity.A prospective single-centre observational study was conducted in a university-affiliated paediatric teaching hospital, comparing children (0-18 months) hospitalised for viral bronchiolitis, those admitted to the paediatric intensive care unit with severe disease and healthy age-matched controls. IL-15-related parameters were compared between groups. PCR and microRNA (miRNA) sequencing was undertaken on natural killer (NK) cells collected from study participants.Samples from 88 children with viral bronchiolitis and 43 controls enrolled between 2009 and 2012 were analysed. Peripheral blood mononuclear cell (PBMC) IL-15 mRNA expression was significantly higher in those with moderate severity bronchiolitis compared with controls and those with severe disease. Serum IL-15 levels correlated with disease severity. The relative frequency of NK cells in peripheral blood was significantly reduced in participants with bronchiolitis. The NK cell miRNA transcriptome in bronchiolitis was distinct. Targets of de-regulated miRNA were differentially expressed in bronchiolitis, including JAK3, STAT5A and NFKB1 on the IL-15 signalling pathway.IL-15 is associated with disease severity in children hospitalised with viral bronchiolitis.

Disease Annotations    
Viral Bronchiolitis  (HEP,IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Bcl2  (BCL2, apoptosis regulator)
Il15  (interleukin 15)

Genes (Mus musculus)
Bcl2  (B cell leukemia/lymphoma 2)
Il15  (interleukin 15)

Genes (Homo sapiens)
BCL2  (BCL2 apoptosis regulator)
BCL2L1  (BCL2 like 1)
FAS  (Fas cell surface death receptor)
FLT3  (fms related receptor tyrosine kinase 3)
GAPDH  (glyceraldehyde-3-phosphate dehydrogenase)
IL15  (interleukin 15)
JAK3  (Janus kinase 3)
NFKB1  (nuclear factor kappa B subunit 1)
STAT5A  (signal transducer and activator of transcription 5A)
TNFRSF10A  (TNF receptor superfamily member 10a)

Additional Information