RGD Reference Report - Expression of IL-15 in inflammatory pulmonary diseases. - Rat Genome Database

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Expression of IL-15 in inflammatory pulmonary diseases.

Authors: Muro, S  Taha, R  Tsicopoulos, A  Olivenstein, R  Tonnel, AB  Christodoulopoulos, P  Wallaert, B  Hamid, Q 
Citation: Muro S, etal., J Allergy Clin Immunol. 2001 Dec;108(6):970-5.
RGD ID: 4990461
Pubmed: PMID:11742275   (View Abstract at PubMed)
DOI: DOI:10.1067/mai.2001.119556   (Journal Full-text)

BACKGROUND: IL-15 is a T(H)1-related cytokine that shares many biologic activities with IL-2. Both cytokines bind a specific alpha subunit, and they share the same beta and gamma common receptor subunits for signal transduction. IL-15 has recently been shown to be upregulated in T cell-mediated inflammatory disorders, such as rheumatoid arthritis and inflammatory bowel diseases. However, the role and expression of IL-15 in inflammatory lung disease has not been investigated. OBJECTIVE: In the present study we have evaluated the expression of IL-15 mRNA and protein in bronchial biopsy specimens obtained from patients with sarcoidosis (n = 8), tuberculosis (n = 7), chronic bronchitis (n = 10), and bronchial asthma (n = 8) and compared its expression with that seen in normal control subjects (n = 11). METHODS: In situ hybridization and immunocytochemistry were used to detect the number of cells expressing IL-15 mRNA and protein, respectively, within sections of bronchial tissues from all subject groups. In addition, double immunocytochemistry was used to characterize the cellular source of IL-15. RESULTS: The number of IL-15(+) cells was significantly higher within tissue from patients with sarcoidosis, tuberculosis, and chronic bronchitis compared with that in asthmatic patients and normal control subjects. Similar results were obtained for IL-15 immunoreactivity by using immunohistochemistry. Furthermore, double immunostaining revealed that neutrophils and macrophages are the major source of IL-15. CONCLUSION: These results suggest that the expression of IL-15 may be associated with T(H)1-mediated chronic inflammatory diseases of the lung.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Chronic Bronchitis  IEP 4990461mRNA and protein:increased expression:lungRGD 
Chronic Bronchitis  ISOIL15 (Homo sapiens)4990461; 4990461mRNA and protein:increased expression:lungRGD 
pulmonary sarcoidosis  IEP 4990461mRNA and protein:increased expression:lungRGD 
pulmonary sarcoidosis  ISOIL15 (Homo sapiens)4990461; 4990461mRNA and protein:increased expression:lungRGD 
pulmonary tuberculosis  IEP 4990461mRNA and protein:increased expression:lungRGD 
pulmonary tuberculosis  ISOIL15 (Homo sapiens)4990461; 4990461mRNA and protein:increased expression:lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il15  (interleukin 15)

Genes (Mus musculus)
Il15  (interleukin 15)

Genes (Homo sapiens)
IL15  (interleukin 15)


Additional Information