Il15 (interleukin 15) - Rat Genome Database

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Gene: Il15 (interleukin 15) Mus musculus
Analyze
Symbol: Il15
Name: interleukin 15
RGD ID: 10786
MGI Page MGI
Description: Enables cytokine activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including T cell activation; lymph node development; and regulation of lymphocyte activation. Located in cytoplasm. Is expressed in several structures, including genitourinary system; gut; immune system; nervous system; and olfactory epithelium. Human ortholog(s) of this gene implicated in aspergillosis; asthma; pleurisy; and type 1 diabetes mellitus. Orthologous to human IL15 (interleukin 15).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI503618; IL-15; interleukin-15
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39883,058,253 - 83,129,883 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl883,058,261 - 83,129,851 (-)EnsemblGRCm39 Ensembl
GRCm38882,331,624 - 82,403,252 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl882,331,632 - 82,403,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37884,855,523 - 84,926,444 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36885,227,371 - 85,298,292 (-)NCBIMGSCv36mm8
Celera886,620,550 - 86,691,831 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map839.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-Nitrobenzanthrone  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
asperentin  (EXP)
atrazine  (ISO)
belinostat  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
colistin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-penicillamine  (ISO)
dapagliflozin  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diethyl malate  (EXP)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
emodin  (EXP)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethyl methanesulfonate  (ISO)
formaldehyde  (EXP,ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
hexachlorobenzene  (ISO)
hydroquinone  (ISO)
irinotecan  (ISO)
levamisole  (EXP)
lipid As  (ISO)
lipopolysaccharide  (EXP,ISO)
m-xylene  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
molibresib  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nonanoic acid  (EXP)
notoginsenoside R1  (EXP)
Olmesartan medoxomil  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD 0325901  (ISO)
permethrin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
Pyridostigmine bromide  (ISO)
quercitrin  (ISO)
quinolin-8-ol  (EXP)
riddelliine  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP)
sterigmatocystin  (EXP)
sulfadimethoxine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
TMC-120A  (EXP)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
trovafloxacin  (EXP)
urethane  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (ISO)
cytoplasm  (IDA)
cytosol  (IEA,ISO)
extracellular region  (TAS)
extracellular space  (IBA,IEA,ISO)
nuclear speck  (IEA,ISO)
nucleoplasm  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD8-positive, alpha-beta T cell differentiation  (IAGP)
abnormal CD8-positive, alpha-beta T cell physiology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal decidualization  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal lymphocyte morphology  (IAGP)
abnormal NK cell differentiation  (IAGP)
abnormal NK T cell number  (IAGP)
abnormal spleen B cell follicle morphology  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal thymus cell ratio  (IAGP)
abnormal uterine artery morphology  (IAGP)
absent uterine NK cells  (IAGP)
decreased body weight  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, gamma-delta intraepithelial T cell number  (IAGP)
decreased dendritic cell number  (IAGP)
decreased IgG level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased memory T cell number  (IAGP)
decreased NK cell number  (IAGP)
decreased NK T cell number  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
enlarged heart  (IEA)
impaired glucose tolerance  (IEA)
impaired natural killer cell mediated cytotoxicity  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased grip strength  (IEA)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG2b level  (IAGP)
increased monocyte cell number  (IAGP)
increased splenocyte number  (IAGP)
increased susceptibility to Herpesvirales infection induced morbidity/mortality  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to Poxviridae infection induced morbidity/mortality  (IAGP)
increased susceptibility to systemic lupus erythematosus  (IAGP)
limb grasping  (IEA)
premature death  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
small lymph nodes  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Cytokine profile during latent and slowly progressive primary tuberculosis: a possible role for interleukin-15 in mediating clinical disease. Abebe F, etal., Clin Exp Immunol. 2006 Jan;143(1):180-92.
2. Host Response Cytokine Signatures in Viral and Nonviral Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Almansa R, etal., J Interferon Cytokine Res. 2011 Jan 15.
3. IL-15 prevents allergic rhinitis through reactivation of antigen-specific CD8+ cells. Aoi N, etal., J Allergy Clin Immunol. 2006 Jun;117(6):1359-66. Epub 2006 Apr 3.
4. Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza. Bermejo-Martin JF, etal., Crit Care. 2009;13(6):R201. Epub 2009 Dec 11.
5. Confirmation of association of IL-15 with pediatric asthma and comparison of different controls. Bierbaum S, etal., Allergy. 2006 May;61(5):576-80.
6. Autocrine role of vascular IL-15 in intimal thickening. Cercek M, etal., Biochem Biophys Res Commun. 2006 Jan 13;339(2):618-23. Epub 2005 Nov 18.
7. Differential diagnosis of pleural effusions by fuzzy-logic-based analysis of cytokines. Chomej P, etal., Respir Med. 2004 Apr;98(4):308-17.
8. Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis. Desai B, etal., Exp Lung Res. 2011 May;37(4):227-38. Epub 2011 Feb 11.
9. Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. Galkowska H, etal., Wound Repair Regen. 2006 Sep-Oct;14(5):558-65.
10. Clinical aspects and cytokine response in severe H1N1 influenza A virus infection. Hagau N, etal., Crit Care. 2010;14(6):R203. Epub 2010 Nov 9.
11. Interleukin-15 may be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats. Hirose K, etal., Infect Immun. 1998 Dec;66(12):5677-83.
12. Cell-specific interleukin-15 and interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia--comparison to chlamydial lung infection. Hocke AC, etal., Cytokine. 2007 May;38(2):61-73. Epub 2007 Jul 3.
13. Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in a murine model of asthma. Ishimitsu R, etal., J Immunol. 2001 Feb 1;166(3):1991-2001.
14. Serum interleukin-15 concentration in patients with essential hypertension. Kaibe M, etal., Am J Hypertens. 2005 Aug;18(8):1019-25.
15. Significant expression of interleukin 15 in rat experimental severe acute pancreatitis. Kamei K, etal., Eur Surg Res. 2010;44(3-4):159-69. Epub 2010 Mar 24.
16. Synergistic effect of interleukin-15 and interleukin-12 on antitumor activity in a murine malignant pleurisy model. Kimura K, etal., Cancer Immunol Immunother. 2000 May;49(2):71-7.
17. Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Koulmanda M, etal., Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13074-9. Epub 2007 Aug 1.
18. IL-15 is elevated in serum patients with type 1 diabetes mellitus. Kuczynski S, etal., Diabetes Res Clin Pract. 2005 Sep;69(3):231-6. Epub 2005 Mar 31.
19. Multilocus haplotype analyses reveal association between 5 novel IL-15 polymorphisms and asthma. Kurz T, etal., J Allergy Clin Immunol. 2004 May;113(5):896-901.
20. Interleukin-15 is associated with disease severity in viral bronchiolitis. Leahy TR, etal., Eur Respir J. 2016 Jan;47(1):212-22. doi: 10.1183/13993003.00642-2015. Epub 2015 Nov 5.
21. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Li Y, etal., Mol Oral Microbiol. 2010 Aug;25(4):275-92.
22. Proinflammatory cytokines in injured rat brain following perinatal asphyxia. Maslinska D, etal., Folia Neuropathol. 2002;40(4):177-82.
23. IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection. McGill J, etal., J Exp Med. 2010 Mar 15;207(3):521-34. Epub 2010 Mar 8.
24. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
25. MGDs mouse GO annotations MGD data from the GO Consortium
26. MGD IEA MGD IEA
27. Gr-1high polymorphonuclear leukocytes and NK cells act via IL-15 to clear intracellular Haemophilus influenzae in experimental murine peritonitis and pneumonia. Miyazaki S, etal., J Immunol. 2007 Oct 15;179(8):5407-14.
28. Expression of IL-15 in inflammatory pulmonary diseases. Muro S, etal., J Allergy Clin Immunol. 2001 Dec;108(6):970-5.
29. Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury. Nakamura R, etal., J Virol. 2010 Jun;84(11):5574-82. Epub 2010 Mar 24.
30. Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass. Nielsen AR, etal., J Clin Endocrinol Metab. 2008 Nov;93(11):4486-93. Epub 2008 Aug 12.
31. Inflammation and functional outcome in diisocyanate-induced asthma after cessation of exposure. Piirila PL, etal., Allergy. 2008 May;63(5):583-91.
32. IL15 gene variants are not associated with asthma and atopy. Pinto LA, etal., Allergy. 2009 Apr;64(4):643-6. Epub 2008 Dec 24.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in mice. Poon LL, etal., J Immunol. 2009 Mar 1;182(5):3063-71.
35. A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats. Qaisar N, etal., Diabetes. 2017 Jan;66(1):145-157. doi: 10.2337/db16-0462. Epub 2016 Oct 7.
36. Natural killer cell-mediated cytokine response among HIV-positive south Indians with pulmonary tuberculosis. Ramana Rao PV, etal., J Interferon Cytokine Res. 2010 Jan;30(1):33-42.
37. Intestinal epithelial cells both express and respond to interleukin 15. Reinecker HC, etal., Gastroenterology. 1996 Dec;111(6):1706-13.
38. Mouse MP Annotation Import Pipeline RGD automated import pipeline
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Immunoregulation during disease progression in prediabetic NOD mice: inverse expression of arginase and prostaglandin H synthase 2 vs. interleukin-15. Rothe H, etal., Horm Metab Res. 2002 Jan;34(1):7-12.
41. Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo. Ruckert R, etal., J Immunol. 2005 May 1;174(9):5507-15.
42. Cytokine profiling of pulmonary aspergillosis. Sambatakou H, etal., Int J Immunogenet. 2006 Aug;33(4):297-302.
43. NK cells play a critical protective role in host defense against acute extracellular Staphylococcus aureus bacterial infection in the lung. Small CL, etal., J Immunol. 2008 Apr 15;180(8):5558-68.
44. A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection. Verbist KC, etal., J Immunol. 2011 Jan 1;186(1):174-82. Epub 2010 Nov 22.
45. Interleukin-15 receptor-directed immunotoxins atteunuate disease severity in rat adjuvant arthritis. Wang D, etal., Mol Immunol. 2010 Apr;47(7-8):1535-43. Epub 2010 Feb 25.
46. Increased expression of non-interleukin-2 T cell growth factors and their implications during liver allograft rejection in rats. Wang WL, etal., J Gastroenterol Hepatol. 2007 Jul;22(7):1141-7. Epub 2007 May 27.
47. Expression of interleukin-15 in mouse and human atherosclerotic lesions. Wuttge DM, etal., Am J Pathol. 2001 Aug;159(2):417-23.
48. Serum IL-15 in patients with early systemic sclerosis: a potential novel marker of lung disease. Wuttge DM, etal., Arthritis Res Ther. 2007;9(5):R85.
Additional References at PubMed
PMID:7553894   PMID:7759105   PMID:7759955   PMID:8613692   PMID:8929454   PMID:8976195   PMID:9191120   PMID:9360952   PMID:9394814   PMID:9398835   PMID:9502767   PMID:9551932  
PMID:9619371   PMID:9838089   PMID:10087299   PMID:10349636   PMID:10620614   PMID:10689297   PMID:10704459   PMID:11016962   PMID:11017787   PMID:11042159   PMID:11076861   PMID:11135625  
PMID:11217851   PMID:11358383   PMID:11441103   PMID:11447288   PMID:11466332   PMID:11702064   PMID:11737071   PMID:11801655   PMID:11927622   PMID:11986256   PMID:11992548   PMID:11994430  
PMID:12045244   PMID:12055269   PMID:12070279   PMID:12070280   PMID:12070281   PMID:12070282   PMID:12077277   PMID:12244311   PMID:12370359   PMID:12372339   PMID:12393617   PMID:12393656  
PMID:12405201   PMID:12444123   PMID:12453470   PMID:12466851   PMID:12477932   PMID:12518454   PMID:12574382   PMID:12586624   PMID:12598649   PMID:12648490   PMID:12717626   PMID:12816981  
PMID:12883202   PMID:12887272   PMID:12893770   PMID:12902507   PMID:12960317   PMID:12964046   PMID:14581351   PMID:14599848   PMID:14607906   PMID:14607951   PMID:14634095   PMID:14635060  
PMID:14688303   PMID:14762166   PMID:14971031   PMID:15019287   PMID:15067057   PMID:15170228   PMID:15187107   PMID:15187148   PMID:15197277   PMID:15214050   PMID:15245428   PMID:15280205  
PMID:15294943   PMID:15345588   PMID:15347678   PMID:15353479   PMID:15367431   PMID:15374888   PMID:15477598   PMID:15489334   PMID:15494535   PMID:15499555   PMID:15501812   PMID:15557143  
PMID:15557159   PMID:15629891   PMID:15630141   PMID:15661875   PMID:15749896   PMID:15767447   PMID:15778359   PMID:15814683   PMID:15845497   PMID:15845528   PMID:15879093   PMID:15932944  
PMID:15951205   PMID:15976176   PMID:16020505   PMID:16047340   PMID:16078277   PMID:16081806   PMID:16134085   PMID:16141072   PMID:16141073   PMID:16162679   PMID:16216888   PMID:16273100  
PMID:16365444   PMID:16449532   PMID:16456010   PMID:16510164   PMID:16547238   PMID:16614074   PMID:16621990   PMID:16631325   PMID:16715101   PMID:16723256   PMID:16757567   PMID:16757683  
PMID:16781000   PMID:16785504   PMID:16788095   PMID:16791279   PMID:16860759   PMID:16880398   PMID:16887981   PMID:16966429   PMID:16973386   PMID:17056533   PMID:17114431   PMID:17202336  
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PMID:17643110   PMID:17646407   PMID:17664294   PMID:17668897   PMID:17723218   PMID:17823984   PMID:17855567   PMID:17878363   PMID:17901247   PMID:17906118   PMID:17923504   PMID:17923507  
PMID:17938253   PMID:17938255   PMID:17952078   PMID:17979156   PMID:18035418   PMID:18097009   PMID:18227350   PMID:18322181   PMID:18339305   PMID:18354159   PMID:18362335   PMID:18384647  
PMID:18390713   PMID:18413772   PMID:18425373   PMID:18426983   PMID:18453565   PMID:18458113   PMID:18465774   PMID:18485336   PMID:18490727   PMID:18523252   PMID:18523259   PMID:18557790  
PMID:18566388   PMID:18606663   PMID:18656487   PMID:18689546   PMID:18714000   PMID:18715907   PMID:18812469   PMID:18941182   PMID:18987248   PMID:19001550   PMID:19004955   PMID:19015248  
PMID:19015253   PMID:19029903   PMID:19050240   PMID:19084435   PMID:19124750   PMID:19155490   PMID:19155493   PMID:19180469   PMID:19303389   PMID:19361783   PMID:19366803   PMID:19380870  
PMID:19383782   PMID:19513536   PMID:19536071   PMID:19544306   PMID:19553528   PMID:19559672   PMID:19604492   PMID:19609975   PMID:19610094   PMID:19632221   PMID:19642895   PMID:19648279  
PMID:19747902   PMID:19786554   PMID:19801677   PMID:19850890   PMID:19854259   PMID:19913445   PMID:19949092   PMID:19949423   PMID:19958157   PMID:20021484   PMID:20023630   PMID:20026737  
PMID:20070942   PMID:20075162   PMID:20086176   PMID:20101507   PMID:20142363   PMID:20142427   PMID:20213736   PMID:20303179   PMID:20308599   PMID:20354106   PMID:20430449   PMID:20439722  
PMID:20483725   PMID:20519649   PMID:20520779   PMID:20538758   PMID:20554759   PMID:20581314   PMID:20592282   PMID:20644163   PMID:20844537   PMID:20974986   PMID:21041729   PMID:21076068  
PMID:21093318   PMID:21098276   PMID:21115056   PMID:21116636   PMID:21155807   PMID:21160039   PMID:21233417   PMID:21267068   PMID:21304101   PMID:21430227   PMID:21477795   PMID:21508317  
PMID:21572025   PMID:21715685   PMID:21723537   PMID:21765213   PMID:21873635   PMID:21874651   PMID:21894465   PMID:21928282   PMID:21928285   PMID:21964024   PMID:21967894   PMID:22084435  
PMID:22124325   PMID:22187674   PMID:22206904   PMID:22267581   PMID:22312130   PMID:22327071   PMID:22346732   PMID:22366950   PMID:22379028   PMID:22380514   PMID:22447977   PMID:22496150  
PMID:22539288   PMID:22565311   PMID:22665806   PMID:22705105   PMID:22879925   PMID:22890824   PMID:22925929   PMID:22940097   PMID:22993203   PMID:23018454   PMID:23018461   PMID:23028657  
PMID:23063333   PMID:23065157   PMID:23109710   PMID:23153537   PMID:23161867   PMID:23201098   PMID:23209317   PMID:23296703   PMID:23355736   PMID:23355737   PMID:23505315   PMID:23536631  
PMID:23583421   PMID:23589611   PMID:23603794   PMID:23676498   PMID:23686479   PMID:23754237   PMID:23804716   PMID:23805138   PMID:23873932   PMID:23966624   PMID:24055061   PMID:24058177  
PMID:24062413   PMID:24169546   PMID:24194600   PMID:24416335   PMID:24421391   PMID:24449915   PMID:24509081   PMID:24510126   PMID:24516120   PMID:24572789   PMID:24657179   PMID:24670802  
PMID:24700781   PMID:24711580   PMID:24740507   PMID:24777831   PMID:24781052   PMID:24825007   PMID:24995967   PMID:25009203   PMID:25103021   PMID:25124553   PMID:25142300   PMID:25142413  
PMID:25148024   PMID:25333902   PMID:25355926   PMID:25500198   PMID:25517731   PMID:25548153   PMID:25615554   PMID:25681766   PMID:25748019   PMID:25756182   PMID:25838430   PMID:25879689  
PMID:25902870   PMID:25907558   PMID:25920499   PMID:25923039   PMID:25931426   PMID:25974878   PMID:25997501   PMID:26195801   PMID:26241055   PMID:26255115   PMID:26269523   PMID:26426795  
PMID:26479922   PMID:26526997   PMID:26600079   PMID:26605524   PMID:26719339   PMID:26778709   PMID:26806130   PMID:26812159   PMID:26853723   PMID:26868085   PMID:26876593   PMID:26964669  
PMID:27097762   PMID:27102484   PMID:27114551   PMID:27135790   PMID:27166125   PMID:27183627   PMID:27356750   PMID:27376238   PMID:27385825   PMID:27457412   PMID:27551096   PMID:27573835  
PMID:27608420   PMID:27626380   PMID:27648810   PMID:27659424   PMID:27684068   PMID:27798617   PMID:27824945   PMID:27837016   PMID:27863332   PMID:27899224   PMID:27986749   PMID:27994144  
PMID:28031340   PMID:28093832   PMID:28110119   PMID:28286036   PMID:28348274   PMID:28361874   PMID:28362433   PMID:28507024   PMID:28514662   PMID:28540653   PMID:28606589   PMID:28636955  
PMID:28723549   PMID:28807496   PMID:28811289   PMID:28814601   PMID:28874785   PMID:28888485   PMID:29186108   PMID:29222435   PMID:29363170   PMID:29449577   PMID:29526762   PMID:29616032  
PMID:29624673   PMID:29625893   PMID:29652930   PMID:29688375   PMID:29728511   PMID:29884699   PMID:30022064   PMID:30029643   PMID:30110639   PMID:30380412   PMID:30587590   PMID:30654941  
PMID:30698677   PMID:30833178   PMID:30891737   PMID:31127035   PMID:31269440   PMID:31552035   PMID:31875880   PMID:32102931   PMID:32103006   PMID:32268106   PMID:32293057   PMID:32504069  
PMID:32582853   PMID:32616380   PMID:32708537   PMID:33628206   PMID:33732245   PMID:33989745   PMID:34165144   PMID:34630428   PMID:34769128   PMID:34956227   PMID:35021100   PMID:35100657  
PMID:35250857   PMID:35444279   PMID:35474218   PMID:35487480   PMID:35618834   PMID:35899872   PMID:36159793   PMID:36263815   PMID:36269840   PMID:36454338   PMID:36524995   PMID:36765626  
PMID:36897958   PMID:37071397   PMID:37105715   PMID:37308419   PMID:37329887   PMID:37636066   PMID:37729919   PMID:37747317   PMID:37802467   PMID:37992787   PMID:38217855   PMID:38271093  
PMID:38294696   PMID:38305633   PMID:38355793   PMID:38446900   PMID:38919611  


Genomics

Comparative Map Data
Il15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39883,058,253 - 83,129,883 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl883,058,261 - 83,129,851 (-)EnsemblGRCm39 Ensembl
GRCm38882,331,624 - 82,403,252 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl882,331,632 - 82,403,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37884,855,523 - 84,926,444 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36885,227,371 - 85,298,292 (-)NCBIMGSCv36mm8
Celera886,620,550 - 86,691,831 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map839.33NCBI
IL15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384141,636,583 - 141,733,987 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4141,636,583 - 141,733,987 (+)EnsemblGRCh38hg38GRCh38
GRCh374142,557,736 - 142,655,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364142,777,204 - 142,874,062 (+)NCBINCBI36Build 36hg18NCBI36
Build 344142,997,904 - 143,012,216NCBI
Celera4139,888,493 - 139,985,377 (+)NCBICelera
Cytogenetic Map4q31.21NCBI
HuRef4138,287,515 - 138,384,970 (+)NCBIHuRef
CHM1_14142,535,127 - 142,632,588 (+)NCBICHM1_1
T2T-CHM13v2.04144,953,939 - 145,051,309 (+)NCBIT2T-CHM13v2.0
Il15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81942,536,160 - 42,611,349 (+)NCBIGRCr8
mRatBN7.21925,640,025 - 25,706,818 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1925,640,251 - 25,706,820 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1932,488,865 - 32,555,378 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01933,142,935 - 33,209,458 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01935,364,627 - 35,431,235 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01923,542,606 - 23,624,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1923,542,889 - 23,554,594 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01934,532,033 - 34,598,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41927,487,268 - 27,498,973 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11927,437,760 - 27,504,081 (+)NCBI
Celera1925,228,574 - 25,240,279 (+)NCBICelera
Celera1925,174,648 - 25,228,568 (+)NCBICelera
Cytogenetic Map19q11NCBI
Il15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554711,497,483 - 1,511,469 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554711,496,352 - 1,583,919 (-)NCBIChiLan1.0ChiLan1.0
IL15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23139,519,329 - 139,630,011 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14139,907,214 - 140,017,980 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04133,693,995 - 134,115,470 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14145,307,339 - 145,416,622 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4145,402,111 - 145,416,622 (+)Ensemblpanpan1.1panPan2
IL15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1191,339,607 - 1,364,762 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl191,339,967 - 1,364,762 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha191,586,489 - 1,611,118 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0191,361,003 - 1,425,159 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl191,361,363 - 1,373,768 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1191,341,699 - 1,366,271 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0191,703,298 - 1,727,862 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0192,058,426 - 2,083,219 (-)NCBIUU_Cfam_GSD_1.0
Il15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530148,906,307 - 48,919,895 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365356,344,395 - 6,350,197 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365356,344,348 - 6,358,803 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl885,667,321 - 85,678,461 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1885,666,963 - 85,740,980 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2890,963,736 - 91,036,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1788,548,773 - 88,644,977 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl788,548,671 - 88,645,488 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603768,097,083 - 68,194,427 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248531,128,519 - 1,144,941 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248531,059,625 - 1,144,799 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il15
2358 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:102
Interacting mature miRNAs:112
Transcripts:ENSMUST00000034148
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88079340489740987Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86872247983326976Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7158942790929226Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse

Markers in Region
AI503618  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38882,331,824 - 82,331,903UniSTSGRCm38
MGSCv37884,855,723 - 84,855,802UniSTSGRCm37
Celera886,620,749 - 86,620,828UniSTS
Cytogenetic Map8C2UniSTS
cM Map838.0UniSTS
Whitehead/MRC_RH8886.32UniSTS
D8Mit343  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38882,357,768 - 82,357,920UniSTSGRCm38
MGSCv37884,881,667 - 84,881,819UniSTSGRCm37
Cytogenetic Map8C2UniSTS
cM Map837.3UniSTS
Whitehead Genetic838.3UniSTS
Whitehead_YAC8 UniSTS
U14332  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38882,331,824 - 82,331,904UniSTSGRCm38
MGSCv37884,855,723 - 84,855,803UniSTSGRCm37
Celera886,620,749 - 86,620,829UniSTS
Cytogenetic Map8C2UniSTS
cM Map838.0UniSTS
Whitehead/MRC_RH8881.49UniSTS
Il15  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C2UniSTS
cM Map838.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001254747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011248312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011248313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011248314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB006745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB022307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC156993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF038164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ012587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX523783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ137432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ083236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ083237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000034148   ⟹   ENSMUSP00000034148
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl883,058,266 - 83,129,851 (-)Ensembl
GRCm38.p6 Ensembl882,331,637 - 82,403,222 (-)Ensembl
Ensembl Acc Id: ENSMUST00000209363   ⟹   ENSMUSP00000147848
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl883,058,261 - 83,129,199 (-)Ensembl
GRCm38.p6 Ensembl882,331,632 - 82,402,570 (-)Ensembl
Ensembl Acc Id: ENSMUST00000209573   ⟹   ENSMUSP00000148256
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl883,058,266 - 83,128,462 (-)Ensembl
GRCm38.p6 Ensembl882,331,637 - 82,401,833 (-)Ensembl
Ensembl Acc Id: ENSMUST00000209687
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl883,058,543 - 83,071,102 (-)Ensembl
GRCm38.p6 Ensembl882,331,914 - 82,344,473 (-)Ensembl
Ensembl Acc Id: ENSMUST00000210094   ⟹   ENSMUSP00000147312
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl883,070,632 - 83,128,995 (-)Ensembl
GRCm38.p6 Ensembl882,344,003 - 82,402,366 (-)Ensembl
Ensembl Acc Id: ENSMUST00000210472
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl883,106,118 - 83,129,838 (-)Ensembl
GRCm38.p6 Ensembl882,379,489 - 82,403,209 (-)Ensembl
Ensembl Acc Id: ENSMUST00000210885
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl883,072,291 - 83,125,256 (-)Ensembl
GRCm38.p6 Ensembl882,345,662 - 82,398,627 (-)Ensembl
Ensembl Acc Id: ENSMUST00000211282
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl883,072,274 - 83,129,122 (-)Ensembl
GRCm38.p6 Ensembl882,345,645 - 82,402,493 (-)Ensembl
Ensembl Acc Id: ENSMUST00000211565   ⟹   ENSMUSP00000147319
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl883,058,368 - 83,072,312 (-)Ensembl
GRCm38.p6 Ensembl882,331,739 - 82,345,683 (-)Ensembl
Ensembl Acc Id: ENSMUST00000211722
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl883,058,543 - 83,071,102 (-)Ensembl
GRCm38.p6 Ensembl882,331,914 - 82,344,473 (-)Ensembl
RefSeq Acc Id: NM_001254747   ⟹   NP_001241676
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,258 - 83,129,191 (-)NCBI
GRCm38882,331,624 - 82,402,586 (-)NCBI
Celera886,620,550 - 86,691,872 (-)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008357   ⟹   NP_032383
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,258 - 83,129,191 (-)NCBI
GRCm38882,331,624 - 82,402,586 (-)NCBI
MGSCv37884,855,523 - 84,926,444 (-)RGD
Celera886,620,550 - 86,691,872 (-)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530705   ⟹   XP_006530768
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,882 (-)NCBI
GRCm38882,331,624 - 82,403,251 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530706   ⟹   XP_006530769
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,882 (-)NCBI
GRCm38882,331,624 - 82,403,251 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530707   ⟹   XP_006530770
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,882 (-)NCBI
GRCm38882,331,624 - 82,403,251 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530708   ⟹   XP_006530771
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,882 (-)NCBI
GRCm38882,331,624 - 82,403,251 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530709   ⟹   XP_006530772
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,128,883 (-)NCBI
GRCm38882,331,624 - 82,402,260 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530710   ⟹   XP_006530773
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,125,266 (-)NCBI
GRCm38882,331,624 - 82,398,641 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530711   ⟹   XP_006530774
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,882 (-)NCBI
GRCm38882,331,624 - 82,403,251 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530712   ⟹   XP_006530775
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,882 (-)NCBI
GRCm38882,331,624 - 82,403,251 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530713   ⟹   XP_006530776
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,882 (-)NCBI
GRCm38882,331,624 - 82,403,251 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530714   ⟹   XP_006530777
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,883 (-)NCBI
GRCm38882,331,624 - 82,403,252 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530715   ⟹   XP_006530778
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,883 (-)NCBI
GRCm38882,331,629 - 82,403,252 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011248312   ⟹   XP_011246614
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,882 (-)NCBI
GRCm38882,331,624 - 82,403,251 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011248313   ⟹   XP_011246615
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,882 (-)NCBI
GRCm38882,331,624 - 82,403,251 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011248314   ⟹   XP_011246616
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,882 (-)NCBI
GRCm38882,331,624 - 82,403,251 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243304   ⟹   XP_030099164
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,361 (-)NCBI
GRCm38882,331,629 - 82,402,732 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153765   ⟹   XP_036009658
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39883,058,253 - 83,129,882 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001241676 (Get FASTA)   NCBI Sequence Viewer  
  NP_032383 (Get FASTA)   NCBI Sequence Viewer  
  XP_006530768 (Get FASTA)   NCBI Sequence Viewer  
  XP_006530769 (Get FASTA)   NCBI Sequence Viewer  
  XP_006530770 (Get FASTA)   NCBI Sequence Viewer  
  XP_006530771 (Get FASTA)   NCBI Sequence Viewer  
  XP_006530772 (Get FASTA)   NCBI Sequence Viewer  
  XP_006530773 (Get FASTA)   NCBI Sequence Viewer  
  XP_006530774 (Get FASTA)   NCBI Sequence Viewer  
  XP_006530775 (Get FASTA)   NCBI Sequence Viewer  
  XP_006530776 (Get FASTA)   NCBI Sequence Viewer  
  XP_006530777 (Get FASTA)   NCBI Sequence Viewer  
  XP_006530778 (Get FASTA)   NCBI Sequence Viewer  
  XP_011246614 (Get FASTA)   NCBI Sequence Viewer  
  XP_011246615 (Get FASTA)   NCBI Sequence Viewer  
  XP_011246616 (Get FASTA)   NCBI Sequence Viewer  
  XP_030099164 (Get FASTA)   NCBI Sequence Viewer  
  XP_036009658 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA75377 (Get FASTA)   NCBI Sequence Viewer  
  AAH23698 (Get FASTA)   NCBI Sequence Viewer  
  AAZ30727 (Get FASTA)   NCBI Sequence Viewer  
  AAZ30728 (Get FASTA)   NCBI Sequence Viewer  
  BAA37122 (Get FASTA)   NCBI Sequence Viewer  
  BAE33347 (Get FASTA)   NCBI Sequence Viewer  
  CAA10069 (Get FASTA)   NCBI Sequence Viewer  
  EDL10891 (Get FASTA)   NCBI Sequence Viewer  
  EDL10892 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000034148
  ENSMUSP00000034148.7
  ENSMUSP00000147312.2
  ENSMUSP00000147319.2
  ENSMUSP00000147848
  ENSMUSP00000147848.2
  ENSMUSP00000148256
  ENSMUSP00000148256.3
GenBank Protein P48346 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032383   ⟸   NM_008357
- Peptide Label: preproprotein
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001241676   ⟸   NM_001254747
- Peptide Label: preproprotein
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530777   ⟸   XM_006530714
- Peptide Label: isoform X2
- UniProtKB: Q1AHQ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530778   ⟸   XM_006530715
- Peptide Label: isoform X3
- UniProtKB: Q1AHQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530776   ⟸   XM_006530713
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530771   ⟸   XM_006530708
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530770   ⟸   XM_006530707
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530769   ⟸   XM_006530706
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530775   ⟸   XM_006530712
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530768   ⟸   XM_006530705
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530774   ⟸   XM_006530711
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530772   ⟸   XM_006530709
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530773   ⟸   XM_006530710
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011246615   ⟸   XM_011248313
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011246614   ⟸   XM_011248312
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011246616   ⟸   XM_011248314
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030099164   ⟸   XM_030243304
- Peptide Label: isoform X3
- UniProtKB: Q1AHQ6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000034148   ⟸   ENSMUST00000034148
Ensembl Acc Id: ENSMUSP00000147319   ⟸   ENSMUST00000211565
Ensembl Acc Id: ENSMUSP00000147312   ⟸   ENSMUST00000210094
Ensembl Acc Id: ENSMUSP00000147848   ⟸   ENSMUST00000209363
Ensembl Acc Id: ENSMUSP00000148256   ⟸   ENSMUST00000209573
RefSeq Acc Id: XP_036009658   ⟸   XM_036153765
- Peptide Label: isoform X1
- UniProtKB: P48346 (UniProtKB/Swiss-Prot),   Q3U1Z6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48346-F1-model_v2 AlphaFold P48346 1-162 view protein structure

Promoters
RGD ID:8667579
Promoter ID:EPDNEW_M11821
Type:multiple initiation site
Name:Il15_2
Description:Mus musculus interleukin 15 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11822  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38882,402,987 - 82,403,047EPDNEW
RGD ID:8667581
Promoter ID:EPDNEW_M11822
Type:multiple initiation site
Name:Il15_1
Description:Mus musculus interleukin 15 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11821  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38882,403,213 - 82,403,273EPDNEW
RGD ID:6843315
Promoter ID:MM_KWN:54980
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour
Transcripts:UC009MJJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36884,869,406 - 84,869,906 (-)MPROMDB
RGD ID:6842574
Promoter ID:MM_KWN:54981
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:AK020542_9530004M14RIK,   ENSMUST00000034148,   UC009MJL.1,   UC009MJM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36884,925,621 - 84,927,077 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103014 AgrOrtholog
Ensembl Genes ENSMUSG00000031712 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034148 ENTREZGENE
  ENSMUST00000034148.7 UniProtKB/Swiss-Prot
  ENSMUST00000209363 ENTREZGENE
  ENSMUST00000209363.2 UniProtKB/Swiss-Prot
  ENSMUST00000209573 ENTREZGENE
  ENSMUST00000209573.3 UniProtKB/Swiss-Prot
  ENSMUST00000210094.2 UniProtKB/TrEMBL
  ENSMUST00000211565.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-15/IL-21_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-15_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:103014 ENTREZGENE
NCBI Gene 16168 ENTREZGENE
PANTHER INTERLEUKIN-15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il15 PhenoGen
PRINTS INTLKN15MAML UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKIN15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GQZ2_MOUSE UniProtKB/TrEMBL
  A0A1B0GQZ8_MOUSE UniProtKB/TrEMBL
  IL15_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q1AHQ6 ENTREZGENE, UniProtKB/TrEMBL
  Q1AHQ7 ENTREZGENE, UniProtKB/TrEMBL
  Q3U1Z6 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z0G5_MOUSE UniProtKB/TrEMBL