Nutf2 (nuclear transport factor 2) - Rat Genome Database

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Gene: Nutf2 (nuclear transport factor 2) Rattus norvegicus
Analyze
Symbol: Nutf2
Name: nuclear transport factor 2
RGD ID: 1359213
Description: Enables nuclear import signal receptor activity and small GTPase binding activity. Involved in negative regulation of vascular endothelial growth factor production; positive regulation of protein import into nucleus; and protein localization to nucleus. Located in cytosol and nuclear outer membrane. Part of nuclear pore central transport channel. Used to study diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC72930; NTF-2; NTF2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Nutf2-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,752,319 - 33,773,595 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1933,752,291 - 33,773,591 (+)Ensembl
Rnor_6.01937,830,917 - 37,852,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,830,917 - 37,852,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,697,685 - 48,718,960 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,697,564 - 35,718,839 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11935,702,444 - 35,723,720 (+)NCBI
Celera1933,179,879 - 33,201,155 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP. Bayliss R, etal., J Mol Biol. 1999 Oct 29;293(3):579-93.
2. Separate binding sites on nuclear transport factor 2 (NTF2) for GDP-Ran and the phenylalanine-rich repeat regions of nucleoporins p62 and Nsp1p. Clarkson WD, etal., J Mol Biol. 1996 Nov 8;263(4):517-24.
3. Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran. Clarkson WD, etal., J Mol Biol. 1997 Oct 10;272(5):716-30.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins. Hu T, etal., J Cell Biol 1996 Aug;134(3):589-601.
6. Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import. Kent HM, etal., J Mol Biol. 1999 Jun 11;289(3):565-77.
7. Crystallization and preliminary X-ray diffraction analysis of nuclear transport factor 2. Kent HM, etal., J Struct Biol 1996 Mar-Apr;116(2):326-9.
8. Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy. Li B, etal., Mol Vis. 2009;15:861-9. Epub 2009 Apr 27.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import. Percipalle P, etal., J Mol Biol. 1997 Mar 7;266(4):722-32.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. NTF2 mediates nuclear import of Ran. Ribbeck K, etal., EMBO J. 1998 Nov 16;17(22):6587-98.
14. Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran. Stewart M, etal., J Mol Biol. 1998 Apr 3;277(3):635-46.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:7744965   PMID:8757804   PMID:10567585   PMID:10679025   PMID:15489334   PMID:15689618   PMID:16449645   PMID:18266911   PMID:19098896   PMID:20458337   PMID:22871113   PMID:23376485  
PMID:23533145   PMID:25416956  


Genomics

Comparative Map Data
Nutf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,752,319 - 33,773,595 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1933,752,291 - 33,773,591 (+)Ensembl
Rnor_6.01937,830,917 - 37,852,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,830,917 - 37,852,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,697,685 - 48,718,960 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,697,564 - 35,718,839 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11935,702,444 - 35,723,720 (+)NCBI
Celera1933,179,879 - 33,201,155 (+)NCBICelera
Cytogenetic Map19q12NCBI
NUTF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,846,933 - 67,872,567 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1667,846,882 - 67,872,567 (+)EnsemblGRCh38hg38GRCh38
GRCh371667,880,836 - 67,906,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,438,320 - 66,462,720 (+)NCBINCBI36hg18NCBI36
Build 341666,438,319 - 66,462,719NCBI
Celera1652,389,231 - 52,413,631 (+)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1653,772,086 - 53,778,310 (+)NCBIHuRef
CHM1_11669,289,001 - 69,313,401 (+)NCBICHM1_1
T2T-CHM13v2.01673,642,707 - 73,668,340 (+)NCBI
Nutf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,587,165 - 106,607,034 (+)NCBIGRCm39mm39
GRCm39 Ensembl8106,587,212 - 106,605,962 (+)Ensembl
GRCm388105,860,533 - 105,880,402 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1953,588,168 - 53,589,068 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,860,580 - 105,879,330 (+)EnsemblGRCm38mm10GRCm38
MGSCv378108,384,534 - 108,404,302 (+)NCBIGRCm37mm9NCBIm37
MGSCv368108,749,763 - 108,769,531 (+)NCBImm8
Celera8110,088,387 - 110,108,163 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.05NCBI
Nutf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554848,832,871 - 8,854,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554848,832,871 - 8,854,151 (-)NCBIChiLan1.0ChiLan1.0
NUTF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11667,575,435 - 67,601,053 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,575,842 - 67,601,053 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01648,188,533 - 48,214,205 (+)NCBIMhudiblu_PPA_v0panPan3
NUTF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,614,916 - 81,632,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,604,848 - 81,622,631 (-)NCBI
ROS_Cfam_1.0582,050,257 - 82,068,040 (-)NCBI
ROS_Cfam_1.0 Ensembl582,050,394 - 82,096,914 (-)Ensembl
UMICH_Zoey_3.1581,876,451 - 81,894,465 (-)NCBI
UNSW_CanFamBas_1.0581,558,516 - 81,576,296 (-)NCBI
UU_Cfam_GSD_1.0582,200,756 - 82,218,537 (-)NCBI
Nutf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,356,708 - 41,374,581 (-)NCBI
SpeTri2.0NW_00493647518,214,593 - 18,232,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUTF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,469,505 - 28,489,005 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,469,274 - 28,489,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,643,308 - 25,663,373 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUTF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,567,429 - 59,592,725 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl559,566,171 - 59,592,843 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604722,291,136 - 22,318,807 (-)NCBIVero_WHO_p1.0
Nutf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,504,303 - 18,524,957 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474618,505,935 - 18,525,335 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
AW546000  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2711,961,168 - 11,961,308 (+)MAPPERmRatBN7.2
mRatBN7.21531,592,096 - 31,592,236 (+)MAPPERmRatBN7.2
Rnor_6.01537,710,935 - 37,711,074NCBIRnor6.0
Rnor_6.0715,129,849 - 15,129,988NCBIRnor6.0
Rnor_5.01541,556,792 - 41,556,931UniSTSRnor5.0
Rnor_5.0715,288,979 - 15,289,118UniSTSRnor5.0
RGSC_v3.4713,539,988 - 13,540,127UniSTSRGSC3.4
RGSC_v3.41536,486,687 - 36,486,826UniSTSRGSC3.4
Celera1531,303,241 - 31,303,380UniSTS
Celera710,056,134 - 10,056,273UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map15p12UniSTS
Cytogenetic Map19q12UniSTS
RH139506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,773,371 - 33,773,560 (+)MAPPERmRatBN7.2
Rnor_6.01937,851,969 - 37,852,157NCBIRnor6.0
Rnor_5.01948,718,737 - 48,718,925UniSTSRnor5.0
RGSC_v3.41935,718,616 - 35,718,804UniSTSRGSC3.4
Celera1933,200,932 - 33,201,120UniSTS
RH 3.4 Map19330.7UniSTS
Cytogenetic Map19q12UniSTS
UniSTS:235986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,772,546 - 33,772,750 (+)MAPPERmRatBN7.2
Rnor_6.01937,851,144 - 37,851,347NCBIRnor6.0
Rnor_5.01948,717,912 - 48,718,115UniSTSRnor5.0
RGSC_v3.41935,717,791 - 35,717,994UniSTSRGSC3.4
Celera1933,200,107 - 33,200,310UniSTS
Cytogenetic Map19q12UniSTS
NUTF2_9060  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,772,023 - 33,772,523 (+)MAPPERmRatBN7.2
Rnor_6.01937,850,621 - 37,851,120NCBIRnor6.0
Rnor_5.01948,717,389 - 48,717,888UniSTSRnor5.0
RGSC_v3.41935,717,268 - 35,717,767UniSTSRGSC3.4
Celera1933,199,584 - 33,200,083UniSTS
Cytogenetic Map19q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:695
Count of miRNA genes:278
Interacting mature miRNAs:345
Transcripts:ENSRNOT00000025608
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025608   ⟹   ENSRNOP00000025608
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,752,291 - 33,773,591 (+)Ensembl
Rnor_6.0 Ensembl1937,830,917 - 37,852,189 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101055   ⟹   ENSRNOP00000080316
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,752,312 - 33,772,516 (+)Ensembl
RefSeq Acc Id: NM_001007629   ⟹   NP_001007630
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,752,319 - 33,773,595 (+)NCBI
Rnor_6.01937,830,917 - 37,852,192 (+)NCBI
Rnor_5.01948,697,685 - 48,718,960 (+)NCBI
RGSC_v3.41935,697,564 - 35,718,839 (+)RGD
Celera1933,179,879 - 33,201,155 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255480   ⟹   XP_006255542
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,752,487 - 33,773,595 (+)NCBI
Rnor_6.01937,831,294 - 37,852,192 (+)NCBI
Rnor_5.01948,697,685 - 48,718,960 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097624   ⟹   XP_038953552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,766,238 - 33,773,595 (+)NCBI
RefSeq Acc Id: XM_039097625   ⟹   XP_038953553
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,762,287 - 33,773,595 (+)NCBI
RefSeq Acc Id: XM_039097626   ⟹   XP_038953554
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,760,622 - 33,773,595 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001007630   ⟸   NM_001007629
- UniProtKB: P13662 (UniProtKB/Swiss-Prot),   P61972 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255542   ⟸   XM_006255480
- Peptide Label: isoform X1
- UniProtKB: P13662 (UniProtKB/Swiss-Prot),   P61972 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025608   ⟸   ENSRNOT00000025608
RefSeq Acc Id: XP_038953554   ⟸   XM_039097626
- Peptide Label: isoform X1
- UniProtKB: P13662 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038953553   ⟸   XM_039097625
- Peptide Label: isoform X1
- UniProtKB: P13662 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038953552   ⟸   XM_039097624
- Peptide Label: isoform X1
- UniProtKB: P13662 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000080316   ⟸   ENSRNOT00000101055
Protein Domains
NTF2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61972-F1-model_v2 AlphaFold P61972 1-127 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701090
Promoter ID:EPDNEW_R11614
Type:multiple initiation site
Name:Nutf2_1
Description:nuclear transport factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01937,830,899 - 37,830,959EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359213 AgrOrtholog
BioCyc Gene G2FUF-5805 BioCyc
Ensembl Genes ENSRNOG00000018945 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025608 ENTREZGENE
  ENSRNOP00000025608.4 UniProtKB/TrEMBL
  ENSRNOP00000080316 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025608 ENTREZGENE
  ENSRNOT00000025608.5 UniProtKB/TrEMBL
  ENSRNOT00000101055 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6886638 IMAGE-MGC_LOAD
InterPro NTF2 UniProtKB/Swiss-Prot
  NTF2-like_dom_sf UniProtKB/Swiss-Prot
  NTF2/Mtr2 UniProtKB/Swiss-Prot
  Nuclear_transport_factor_2_euk UniProtKB/Swiss-Prot
KEGG Report rno:291981 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72930 IMAGE-MGC_LOAD
NCBI Gene 291981 ENTREZGENE
PANTHER PTHR12612 UniProtKB/Swiss-Prot
Pfam NTF2 UniProtKB/Swiss-Prot
PhenoGen Nutf2 PhenoGen
PROSITE NTF2_DOMAIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54427 UniProtKB/Swiss-Prot
UniProt A0A8L2QDH9_RAT UniProtKB/TrEMBL
  NTF2_RAT UniProtKB/Swiss-Prot
  P13662 ENTREZGENE
  P61972 ENTREZGENE
UniProt Secondary P13662 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Nutf2  nuclear transport factor 2  NTF2  nuclear transport factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 NTF2  nuclear transport factor 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein may act as a dimer; crystal structure contains two polypeptide chains 1359758