Gene: Man2b1 (mannosidase, alpha, class 2B, member 1) Rattus norvegicus
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Symbol: Man2b1
Name: mannosidase, alpha, class 2B, member 1
Description: ENCODES a protein that exhibits alpha-mannosidase activity; mannose binding; INVOLVED IN cellular protein modification process (ortholog); learning or memory (ortholog); mannose metabolic process (ortholog); ASSOCIATED WITH alpha-mannosidosis (ortholog); genetic disease (ortholog); IgA glomerulonephritis (ortholog); FOUND IN lysosome; extracellular space (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,4-dinitrotoluene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole
AGR Description: Exhibits alpha-mannosidase activity and mannose binding activity; predicted to be involved in learning or memory, mannose metabolic process, and protein deglycosylation; localizes to the lysosome; orthologous to human MAN2B1 (mannosidase alpha class 2B member 1).
Merged Description: Exhibits alpha-mannosidase activity and mannose binding activity; predicted to be involved in learning or memory, mannose metabolic process, and protein deglycosylation; localizes to the lysosome; orthologous to human MAN2B1 (mannosidase alpha class 2B member 1); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,4-dinitrotoluene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: lysosomal alpha-mannosidase; Manb; mannosidase 2, alpha B1; Mannosidase, alpha B, lysosomal; MGC72561; similar to mannosidase 2, alpha B1
Orthologs:
Homo sapiens (human) : MAN2B1 (mannosidase alpha class 2B member 1)  HGNC  Alliance
Mus musculus (house mouse) : Man2b1 (mannosidase 2, alpha B1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Man2b1 (mannosidase alpha class 2B member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MAN2B1 (mannosidase alpha class 2B member 1)
Canis lupus familiaris (dog) : MAN2B1 (mannosidase alpha class 2B member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Man2b1 (mannosidase alpha class 2B member 1)
Sus scrofa (pig) : MAN2B1 (mannosidase alpha class 2B member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01926,196,797 - 26,216,981 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01937,172,434 - 37,191,891 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,711,378 - 24,730,659 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11924,716,204 - 24,735,485 (-)NCBI
Celera1922,613,060 - 22,632,343 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Man2b1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3039
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.