Dnajb1 (DnaJ heat shock protein family (Hsp40) member B1) - Rat Genome Database

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Gene: Dnajb1 (DnaJ heat shock protein family (Hsp40) member B1) Rattus norvegicus
Analyze
Symbol: Dnajb1
Name: DnaJ heat shock protein family (Hsp40) member B1
RGD ID: 1304725
Description: Predicted to enable several functions, including ATPase binding activity; Hsp70 protein binding activity; and transcription regulator inhibitor activity. Involved in forebrain development. Located in dendritic spine; neuronal cell body; and sperm head. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1); PARTICIPATES IN chaperone mediated autophagy pathway; Endoplasmic Reticulum-associated degradation pathway; influenza A pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DnaJ (Hsp40) homolog, subfamily B, member 1; dnaJ homolog subfamily B member 1; LOC361384
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,427,453 - 41,431,141 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1941,427,453 - 41,431,416 (-)EnsemblGRCr8
mRatBN7.21924,522,731 - 24,526,419 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,522,717 - 24,526,458 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1931,344,056 - 31,347,744 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,998,467 - 32,002,155 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,221,242 - 34,224,930 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,747,178 - 24,750,919 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,747,178 - 24,750,919 (+)Ensemblrn6Rnor6.0
Rnor_5.01935,726,334 - 35,730,075 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41926,213,739 - 26,217,480 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1924,065,512 - 24,069,253 (-)NCBICelera
RGSC_v3.11926,218,578 - 26,222,306 (-)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
acetamide  (EXP)
acrolein  (EXP,ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antimonite  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (EXP)
Bardoxolone methyl  (ISO)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buspirone  (EXP)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elesclomol  (ISO)
emodin  (ISO)
endosulfan  (EXP)
epoxiconazole  (EXP,ISO)
ethanol  (ISO)
fenofibrate  (EXP)
flutamide  (EXP)
FR900359  (ISO)
furfural  (ISO)
gefitinib  (ISO)
gentamycin  (EXP)
gliotoxin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imidacloprid  (EXP)
indometacin  (EXP,ISO)
iron dichloride  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
Licochalcone B  (ISO)
linalool  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
metacetamol  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP,ISO)
nickel atom  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
progesterone  (ISO)
propanil  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
pyrrolidine dithiocarbamate  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
XAV939  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)
dendritic spine  (IDA)
glutamatergic synapse  (IDA,IEP)
neuronal cell body  (IDA)
nucleoplasm  (IEA,ISO)
postsynapse  (IDA,IEP)
postsynaptic density  (IDA,IEP)
sperm head  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of a heat-shock protein Hsp40, DjB1, as an acrosome- and a tail-associated component in rodent spermatozoa. Doiguchi M, etal., Mol Reprod Dev. 2007 Feb;74(2):223-32. doi: 10.1002/mrd.20609.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage. Lee KJ, etal., Cell Stress Chaperones. 2004 Mar;9(1):58-68.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Presence of molecular chaperones, heat shock cognate (Hsc) 70 and heat shock proteins (Hsp) 40, in the postsynaptic structures of rat brain. Suzuki T, etal., Brain Res. 1999 Jan 16;816(1):99-110.
10. Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases. Xilouri M and Stefanis L, Mol Cell Neurosci. 2015 May;66(Pt A):29-36. doi: 10.1016/j.mcn.2015.01.003. Epub 2015 Feb 25.
Additional References at PubMed
PMID:9499401   PMID:12477932   PMID:14644449   PMID:18620420   PMID:19056867   PMID:20060297   PMID:21231916   PMID:21630459   PMID:22022600   PMID:23376485   PMID:23921388   PMID:24318877  
PMID:25468996   PMID:27496612  


Genomics

Comparative Map Data
Dnajb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,427,453 - 41,431,141 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1941,427,453 - 41,431,416 (-)EnsemblGRCr8
mRatBN7.21924,522,731 - 24,526,419 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,522,717 - 24,526,458 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1931,344,056 - 31,347,744 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,998,467 - 32,002,155 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,221,242 - 34,224,930 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,747,178 - 24,750,919 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,747,178 - 24,750,919 (+)Ensemblrn6Rnor6.0
Rnor_5.01935,726,334 - 35,730,075 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41926,213,739 - 26,217,480 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1924,065,512 - 24,069,253 (-)NCBICelera
RGSC_v3.11926,218,578 - 26,222,306 (-)NCBI
Cytogenetic Map19q11NCBI
DNAJB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,514,769 - 14,560,391 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1914,513,789 - 14,560,391 (-)Ensemblhg38GRCh38
GRCh371914,625,581 - 14,640,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,486,582 - 14,490,201 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341914,486,581 - 14,490,201NCBI
Celera1914,519,709 - 14,523,328 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,195,571 - 14,199,191 (-)NCBIHuRef
CHM1_11914,625,542 - 14,629,161 (-)NCBICHM1_1
T2T-CHM13v2.01914,641,477 - 14,655,999 (-)NCBIT2T-CHM13v2.0
Dnajb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,334,804 - 84,339,282 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,334,822 - 84,339,282 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38883,608,175 - 83,612,653 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,608,193 - 83,612,653 (+)Ensemblmm10GRCm38
MGSCv37886,132,074 - 86,135,802 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36886,498,298 - 86,502,008 (+)NCBIMGSCv36mm8
Celera887,895,947 - 87,899,699 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.22NCBI
Dnajb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541533,098,210 - 33,103,143 (-)Ensembl
ChiLan1.0NW_00495541533,098,503 - 33,102,125 (-)NCBIChiLan1.0ChiLan1.0
DNAJB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22019,444,576 - 19,448,373 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11918,446,832 - 18,450,618 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,078,201 - 14,081,884 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11914,921,219 - 14,926,473 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,922,389 - 14,926,268 (-)EnsemblpanPan2panpan1.1
DNAJB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,120,604 - 48,131,091 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,121,379 - 48,130,060 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2047,997,072 - 48,007,556 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02048,637,524 - 48,648,012 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,644,175 - 48,648,009 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12047,851,456 - 47,861,943 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,277,833 - 48,288,317 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,520,662 - 48,531,368 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dnajb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,303,265 - 207,315,402 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366593,039,277 - 3,042,972 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366593,039,304 - 3,051,373 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAJB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl264,758,957 - 64,765,485 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1264,761,672 - 64,764,482 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,176,572 - 65,180,388 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNAJB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,173,197 - 13,176,826 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,173,157 - 13,176,877 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660746,478,080 - 6,481,855 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnajb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249011,631,275 - 1,652,488 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249011,631,789 - 1,643,026 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnajb1
48 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:393
Count of miRNA genes:215
Interacting mature miRNAs:259
Transcripts:ENSRNOT00000038879
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000038879   ⟹   ENSRNOP00000032313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,427,453 - 41,431,416 (-)Ensembl
mRatBN7.2 Ensembl1924,522,717 - 24,526,458 (-)Ensembl
Rnor_6.0 Ensembl1924,747,178 - 24,750,919 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079106   ⟹   ENSRNOP00000072055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1924,747,216 - 24,750,904 (+)Ensembl
RefSeq Acc Id: NM_001395149   ⟹   NP_001382078
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,427,453 - 41,431,141 (-)NCBI
mRatBN7.21924,522,731 - 24,526,419 (-)NCBI
RefSeq Acc Id: XM_017601314   ⟹   XP_017456803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,427,453 - 41,431,135 (-)NCBI
mRatBN7.21924,522,731 - 24,526,101 (-)NCBI
Rnor_6.01924,747,541 - 24,750,905 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001382078 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456803 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI59431 (Get FASTA)   NCBI Sequence Viewer  
  EDL92266 (Get FASTA)   NCBI Sequence Viewer  
  EDL92267 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032313.4
RefSeq Acc Id: XP_017456803   ⟸   XM_017601314
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000072055   ⟸   ENSRNOT00000079106
Ensembl Acc Id: ENSRNOP00000032313   ⟸   ENSRNOT00000038879
RefSeq Acc Id: NP_001382078   ⟸   NM_001395149
- UniProtKB: B0K030 (UniProtKB/TrEMBL)
Protein Domains
J

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUU5-F1-model_v2 AlphaFold D3ZUU5 1-371 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701008
Promoter ID:EPDNEW_R11525
Type:initiation region
Name:Dnajb1_1
Description:DnaJ heat shock protein family member B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01924,747,258 - 24,747,318EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304725 AgrOrtholog
BioCyc Gene G2FUF-6017 BioCyc
Ensembl Genes ENSRNOG00000021824 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038879.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.110 UniProtKB/TrEMBL
  Urease metallochaperone UreE, N-terminal domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9089687 IMAGE-MGC_LOAD
InterPro DnaJ_C UniProtKB/TrEMBL
  DnaJ_dom_sf UniProtKB/TrEMBL
  DnaJ_N UniProtKB/TrEMBL
  DnaJ_subfamily_B UniProtKB/TrEMBL
  Heat_shock_DnaJ_CS UniProtKB/TrEMBL
  HSP40/DnaJ_pept-bd UniProtKB/TrEMBL
MGC_CLONE MGC:188751 IMAGE-MGC_LOAD
NCBI Gene 361384 ENTREZGENE
PANTHER DNAJ HOMOLOG SUBFAMILY B MEMBER 1 UniProtKB/TrEMBL
  DNAJ HOMOLOG SUBFAMILY C MEMBER UniProtKB/TrEMBL
Pfam CTDII UniProtKB/TrEMBL
  DnaJ UniProtKB/TrEMBL
PhenoGen Dnajb1 PhenoGen
PRINTS DNAJPROTEIN UniProtKB/TrEMBL
PROSITE DNAJ_1 UniProtKB/TrEMBL
  DNAJ_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021824 RatGTEx
SMART DnaJ UniProtKB/TrEMBL
Superfamily-SCOP DnaJ_N UniProtKB/TrEMBL
  HSP40_DnaJ_pep UniProtKB/TrEMBL
UniProt B0K030 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUU5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Dnajb1  DnaJ heat shock protein family (Hsp40) member B1  Dnajb1  DnaJ (Hsp40) homolog, subfamily B, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dnajb1  DnaJ (Hsp40) homolog, subfamily B, member 1   Dnajb1_predicted  DnaJ (Hsp40) homolog, subfamily B, member 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dnajb1_predicted  DnaJ (Hsp40) homolog, subfamily B, member 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED